Dissecting Streptococcus pyogenes interaction with human

Ijaz, Munazza; Ameen, Fuad; Alfoteih, Yassen; Shamim, Saba; Alshehri, Wafa A.; Murtaza, Ghulam

doi:10.1007/s00203-020-01932-w

Cited by 8 publications

(2 citation statements)

References 86 publications

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“…In particular, Streptococcus pyogenes is a pathogenic species infecting humans exclusively. Mainly found on the nasopharynx, these bacteria are responsible for causing mild to severe diseases, such as pharyngitis, scarlet fever, type II necrotizing fasciitis, and toxic shock syndrome [ 61 ]. Altogether, there are several streptococcal infections to be addressed in humans too.…”

Section: Discussionmentioning

confidence: 99%

Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil

et al. 2022

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Antibiotic resistance is one of the biggest health challenges of our time. We are now facing a post-antibiotic era in which microbial infections, currently treatable, could become fatal. In this scenario, antimicrobial peptides such as bacteriocins represent an alternative solution to traditional antibiotics because they are produced by many organisms and can inhibit bacteria, fungi, and/or viruses. Herein, we assessed the antimicrobial activity and biotechnological potential of 54 Streptococcus agalactiae strains isolated from bovine mastitis. Deferred plate antagonism assays revealed an inhibition spectrum focused on species of the genus Streptococcus—namely, S. pyogenes, S. agalactiae, S. porcinus, and S. uberis. Three genomes were successfully sequenced, allowing for their taxonomic confirmation via a multilocus sequence analysis (MLSA). Virulence potential and antibiotic resistance assessments showed that strain LGMAI_St_08 is slightly more pathogenic than the others. Moreover, the mreA gene was identified in the three strains. This gene is associated with resistance against erythromycin, azithromycin, and spiramycin. Assessments for secondary metabolites and antimicrobial peptides detected the bacteriocin zoocin A. Finally, comparative genomics evidenced high similarity among the genomes, with more significant similarity between the LGMAI_St_11 and LGMAI_St_14 strains. Thus, the current study shows promising antimicrobial and biotechnological potential for the Streptococcus agalactiae strains.

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Section: Discussionmentioning

confidence: 99%

Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil

et al. 2022

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“…Streptococcus pyogenes (aka Group A Streptococcus (GAS)) is a human pathobiont that colonizes the throat and skin and may cause severe diseases (1) such as necrotizing fasciitis or streptococcal toxic shock syndrome (STSS) with high mortality rates (2)(3)(4). GAS is also the most common bacterial cause of pharyngotonsillitis (5).…”

Section: Introductionmentioning

confidence: 99%

Inhibition ofStreptococcus pyogenesbiofilm byLactiplantibacillus plantarumandLacticaseibacillus rhamnosus

Gómez-Mejia,

Orlietti,

Tarnutzer

et al. 2024

Preprint

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The human pathobiont Streptococcus pyogenes forms biofilms and causes invasive infections, such as pharyngotonsillitis and necrotizing fasciitis. Bacterial biofilms are more resilient to antibiotic treatment and new therapeutic strategies are needed to control biofilm-associated infections, such as recurrent pharyngotonsillitis. Lactiplantibacillus plantarum and Lacticaseibacillus rhamnosus are two bacterial commensals used for their probiotic properties. This study aimed to elucidate the anti-biofilm properties of L. plantarum and L. rhamnosus cell-free supernatants (LPSN and LRSN, respectively) on S. pyogenes biofilms grown in vitro in supplemented minimal medium. When planktonic or biofilm S. pyogenes were exposed to LPSN or LRSN, S. pyogenes survival was reduced significantly in a concentration-dependent manner and the effect was more pronounced on preformed biofilms. Enzymatic digestion of LPSN and LRSN suggested that glycolipid compounds might cause the antimicrobial effect. In conclusion, this study indicates that L. plantarum and L. rhamnosus produce glycolipid bioactive compounds that reduce S. pyogenes viability in planktonic and biofilm cultures.

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Purulent Meningitis and Meningoencephalitis

Zinserling

2022

Infectious Lesions of the Central Nervous System

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Dissecting Streptococcus pyogenes interaction with human

Cited by 8 publications

References 86 publications

Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil

Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil

Inhibition ofStreptococcus pyogenesbiofilm byLactiplantibacillus plantarumandLacticaseibacillus rhamnosus

Purulent Meningitis and Meningoencephalitis

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