Disseminated Gonococcal Infection Presenting as Bacteremia and Liver Abscesses in a Healthy Adult

Lee, Min Hye; Byun, Jongkyu; Jung, Myounghwa; Yang, John Jeongseok; Park, Ki-Ho; Moon, Soo-youn; Lee, Hee Joo

doi:10.3947/ic.2015.47.1.60

Cited by 23 publications

(15 citation statements)

References 16 publications

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“…In some instances, gonococcus can spread to the bloodstream, resulting in systemic manifestations which are called DGI – a common cause of clinic or hospital visits in sexually active young adults ( 3 ). Common manifestations of DGI are mild fever, rash, tenosynovitis, and polyarthralgia; however, uncommon manifestations such as myocarditis and liver abscess have been reported in literature ( 4 – 6 ). The rash typically has a maculopapular, pustular, necrotic, or vesicular appearance and occurs in the trunk, limbs, palms, and soles of feet ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Disseminated gonococcal infection: an unusual presentation

Lohani

Nazir

Tachamo

et al. 2016

Journal of Community Hospital Internal Medicine Perspectives

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Gonococcus typically affects the mucosal surfaces but in rare cases can spread to bloodstream causing disseminated gonococcal infection (DGI). The usual presentation of DGI is rash, polyarthralgia, and tenosynovitis. We present the case of a 23-year-old female who presented to our hospital with pustular rash and tenosynovitis of hand and was sent home on Augmentin. Her symptoms worsened despite treatment and she presented back to the ED. On investigation, she was found to have DGI and was appropriately treated. DGI should be kept in mind in sexually active youngsters who have only one or two features of the classic triad of rash, tenosynovitis, and arthritis. Timely management and appropriate treatment of DGI is very important to avoid complications and morbidity.

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Section: Discussionmentioning

confidence: 99%

Disseminated gonococcal infection: an unusual presentation

Lohani

Nazir

Tachamo

et al. 2016

Journal of Community Hospital Internal Medicine Perspectives

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“…Untreated gonorrhea can lead to disseminated gonococcal infection (DGI) when N . gonorrhoeae spreads to the blood or other parts of the body 9 . Gonococcal infections also can facilitate the transmission of HIV 10 .…”

Section: Introductionmentioning

confidence: 99%

Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring

Chen

Premasiri

Ziegler

2018

Sci Rep

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SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures of C. trachomatis and N. gonorrheoae are completely different. N. gonorrheoae SERS spectra are due to the starvation induced nucleotide metabolites adenine and guanine, and the surface associated co-enzyme nicotinamide adenine dinucleotide and are very similar on Au and Ag although the spectrum appears more rapidly on Ag. The C. trachomatis SERS spectrum is dominated by the vibrational features of cell surface proteins. While features attributable to specific residues and the amide backbone characterize the C. trachomatis spectrum on Ag, the corresponding SERS spectrum on Au substrates displays vibrational characteristics of aggregated proteins. The prospects for the development of a SERS based platform for rapid (

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“…Neisseria gonorrhoeae (N. gonorrhoeae ) is a Gram-negative diplococcus and an obligate human pathogen. Gonococci are the causative agents of the sexually transmitted disease gonorrhea and have the potential to enter the bloodstream and cause systemic disseminated infections with severe consequences, such as endocarditis and arthritis [ 28 , 67 , 68 ]. An increasing number of reports are highlighting the threatening development of multidrug-resistant gonococci; thus, new strategies are required to combat this pathogen.…”

Section: The Role Of Sphingosine In Infectious Diseasesmentioning

confidence: 99%

“…Acinetobacter baumannii [21] Brevibacterium epidermidis [25] Burkholderia cepacia [21] Corynebacterium bovis [18] Corynebacterium striatum [18] Corynebacterium jeikium [18] Escherichia coli [18,26,27] Haemophilus influenzae [21] Micrococcus luteus [25] Moraxella catarrhalis [21] Neisseria gonorrhoeae [28] Propionibacterium acnes [25] Pseudomonas aeruginosa [21,22,25,27,[29][30][31][32] Staphylococcus aureus [18,23,25,27,29,33,34] Staphylococcus epidermidis [35] Streptococcus mitis [18] Streptococcus pyogens [25] Streptococcus sanguinis [18] viruses Hepatitis C virus [19] Herpes simplex virus type 1 [36] SARS-CoV-2 [37] fungi…”

Section: Microbes Species References Bacteriamentioning

confidence: 99%

The Anti-Infectious Role of Sphingosine in Microbial Diseases

Liu

Gulbins

et al. 2021

Cells

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Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions. They play crucial roles in regulating pathobiological processes, such as cancer, inflammation, and infectious diseases. The bioactive metabolites ceramide, sphingosine-1-phosphate, and sphingosine have been shown to be involved in the pathogenesis of several microbes. In contrast to ceramide, which often promotes bacterial and viral infections (for instance, by mediating adhesion and internalization), sphingosine, which is released from ceramide by the activity of ceramidases, kills many bacterial, viral, and fungal pathogens. In particular, sphingosine is an important natural component of the defense against bacterial pathogens in the respiratory tract. Pathologically reduced sphingosine levels in cystic fibrosis airway epithelial cells are normalized by inhalation of sphingosine, and coating plastic implants with sphingosine prevents bacterial infections. Pretreatment of cells with exogenous sphingosine also prevents the viral spike protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from interacting with host cell receptors and inhibits the propagation of herpes simplex virus type 1 (HSV-1) in macrophages. Recent examinations reveal that the bactericidal effect of sphingosine might be due to bacterial membrane permeabilization and the subsequent death of the bacteria.

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Disseminated Gonococcal Infection Presenting as Bacteremia and Liver Abscesses in a Healthy Adult

Cited by 23 publications

References 16 publications

Disseminated gonococcal infection: an unusual presentation

Disseminated gonococcal infection: an unusual presentation

Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring

The Anti-Infectious Role of Sphingosine in Microbial Diseases

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