Disseminated Persistent Lymphoid Hyperplasia Containing Epstein-Barr Virus and Clonal Rearrangements of DNA

Paediatric Castleman disease: report of seven cases and review of the literature

“…There is no evidence of identi®able risk factors or causative agents in the development of the disorder. The immune response to viral infection has been proposed but viral cultures have been consistently negative and demonstration by polymerase chain reaction of the Epstein-Barr virus genome [55] and human herpes virus type 8 genome [6] in CD has not allowed any conclusion whether the virus is associated with or is the factor responsible for the disease. Nevertheless, it has been demonstrated that CD is consistently associated with a particular pattern of interleukin-6 gene expression [38].…”

Follicular lymphoid hyperplasia of the palate: Case report and literature review

“…Table 1 shows demographic and clinical features of the 20 cases of FLH of the palate published so far in the English language literature, plus the case herein described (Harsany et al, 1980;Wright and Dunsworth, 1983;Bradley et al, 1987;Davila and Thompson, 1988;Napier and Newlands, 1990;Mopsik et al, 1992;Menasce et al, 2001;Kolokotronis et al, 2003). In addition, Samoszuk et al (1993) described a disseminated, persistent FLH; however, we did not include this paper in our review, as it had some of the histological features of Castleman's disease.…”

“…The condition might represent a primary reactive lymphoid proliferation to some unknown antigenic stimulation or chronic irritation, such as from a partial denture (Wright and Dunsworth, 1983;Kolokotronis et al, 2003). Moreover, Epsteine Barr virus may be associated with an unusual form of aggressive and persistent FLH (Samoszuk et al, 1993). However, no correlation with the use of tobacco, alcohol, medications, or with systemic diseases has been described (Wright and Dunsworth, 1983;Menasce et al, 2001).…”

CD56‐Positive Cutaneous Lymphoma with Multicentric Castleman's Disease‐like Systemic Manifestations

“…EBV is a B-lymphotropic human herpes virus known to be involved in lymphoproliferative diseases. Several studies have identified a high possibility of EBV infection in MCD (12,13). Furthermore, EBV is frequently associated with malignant lymphoma from patients in various immunodeficient states (4,14).…”