Disseminated tuberculosis causing isolated splenic vein thrombosis and multiple splenic abscesses

Jain, Deepak; Verma, Kamal; Jain, Promil

doi:10.1093/omcr/omu042

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Classically, Deep Vein Thrombosis (DVT) are more common in patients with pulmonary tuberculosis. Other unusual sites have been reported in the literature specifically splenic vein thrombosis [ 3 ], pulmonary venous thrombosis with atrial extension [ 4 ], left Ventricular Thrombus similar to our case [ 5 ]. DVT is clinically observed and can be confirmed with laboratory methods in 3–4% of patients with pulmonary tuberculosis [ 2 ].…”

Section: Discussionsupporting

confidence: 76%

Lethal left cardiac thromboembolism in infant: A rare complication of pulmonary tuberculosis

Razafimanjato

Vita

Randriamizao

et al. 2019

Respiratory Medicine Case Reports

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If acute or severe infectious are know that risk factors for venous thromboembolism (VTE), the role active tuberculosis is ill defined, despite different case reports and many small case series have proposed an association between VTE and chronic infectious such as tuberculosis. We are highlighting an exceptional phenomenon correlation between intra-cardiac thromboembolism and pulmonary tuberculosis and concluded that active tuberculosis should include in the physician's evaluation of intra-cardiac thromboembolism risk.

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Section: Discussionsupporting

confidence: 76%

Lethal left cardiac thromboembolism in infant: A rare complication of pulmonary tuberculosis

Razafimanjato

Vita

Randriamizao

et al. 2019

Respiratory Medicine Case Reports

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“…Although the clinically described triad of SVT includes splenomegaly, normal liver enzymes and upper GI bleeding, SVT is diagnosed most often on imaging. 4 – 7 , 11 Increased pressure within the splenic vein from the thrombosis can lead to a localized form of portal hypertension called “sinistral” or “left-sided” portal hypertension, where the venous drainage of the spleen occurs by the collateral circulation that includes the short and posterior gastric veins to the coronary veins, and the gastroepiploic veins to the superior mesenteric vein. 6 , 7 The formation of gastric varices is related to the dilation of the submucosal venous reticulum of the gastric fundus which connects the coronary veins, short and posterior gastric veins.…”

Section: Diseases Of the Splenic Vasculaturementioning

confidence: 99%

Vascular Diseases of the Spleen: A Review

Francisco

Trivedi

et al. 2017

Journal of Clinical and Translational Hepatology

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Vascular diseases of the spleen are relatively uncommon in the clinical practice. However, the reported incidence has been progressively increasing, probably due to advances in the imaging modalities used to detect them. This disease condition often presents with non-specific clinical manifestations, but can be associated with significant morbidity and mortality. This review article aims to provide updated clinical information on the different vascular diseases of the splenic vasculature—splenic vein thrombosis, splenic vein aneurysm, splenic artery aneurysm, splenic arteriovenous fistula, and spontaneous splenorenal shunt—in order to aid clinicians in early diagnosis and management.

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“…[1] Our literature search also yielded isolated case reports describing splenic vein thrombosis occurring secondary to renal abscess, celiac disease, heparin-induced thrombocytopenia, and disseminated tuberculosis. [8,[10][11][12] If malignancy is not the ultimate etiology, most noncirrhotic patients are ultimately diagnosed with a prothrombotic disorder such as protein C/protein S deficiency, myeloproliferative disorders, Factor V Leiden mutation, or mutations in the thrombin gene, [9] and investigations should be undertaken to diagnose these disorders.…”

Section: Discussionmentioning

confidence: 99%

Puzzles in practice: splenic vein thrombosis

McIntyre

Marsh

Walden

2016

Postgraduate Medicine

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This report details a 58-year-old gentleman who presented to his outpatient primary care physician's clinic several times over four weeks for ongoing epigastric pain radiating into his left flank, dry heaving, and constipation. He was presumed to have gastritis at each visit and prescribed escalating doses of proton pump inhibitors. Due to the unrelenting pain, he eventually was admitted to the hospital and diagnosed with splenic vein thrombosis after computed tomography imaging of the abdomen. Our literature search revealed that pancreatic pathology is overwhelmingly the contributing factor to splenic vein thrombosis. Our patient had prominent collateral vasculature, suggesting that his splenic vein thrombosis was chronic in nature and likely the cause of his ongoing abdominal pain. Splenic vein thrombosis is an uncommon cause of abdominal pain, but one that should be included in the treating physician's differential diagnoses when abdominal pain is ongoing despite medical therapy. Although he had no evidence of initial findings on radiography, our patient was eventually diagnosed with biopsy-proven pancreatic cancer. Our case report demonstrates how patients presenting with persistent or worsening abdominal pain despite the use of proton pump inhibitors or other acid reducing agents and potential 'red flag' findings such as decreased appetite and weight loss should be worked up for other potential sources of abdominal pathology.

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Disseminated tuberculosis causing isolated splenic vein thrombosis and multiple splenic abscesses

Cited by 8 publications

References 5 publications

Lethal left cardiac thromboembolism in infant: A rare complication of pulmonary tuberculosis

Lethal left cardiac thromboembolism in infant: A rare complication of pulmonary tuberculosis

Vascular Diseases of the Spleen: A Review

Puzzles in practice: splenic vein thrombosis

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