We address some theoretical issues of the quantum decoherence phenomenon within the neutrino oscillation framework and carry out various tests under DUNE simulated experimental environment. On the theoretical side, we provide a general expression for an invariant decoherence matrix under a quantum basis rotation. On the simulated experimental side, considering a rotation invariant and a non-invariant decoherence matrix, we study the impact on the fitting of the standard oscillation parameters, the sensitivity in the mass hierarchy and CP violation, combining the neutrino and antineutrino mode and all available neutrino oscillation probabilities channels. Furthermore, a sensitivity for the decoherence parameter of order 10 −24 GeV at 3σ, is obtained for our best case.