Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study

Braeutigam, Sven; Dima, Danai; Frangou, Sophia; James, Anthony

doi:10.1016/j.schres.2017.07.048

Cited by 19 publications

(8 citation statements)

References 45 publications

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“…However, if the DNMnet in the brain falls into a more stable state, as in the PD group, the stability may lead to cognitive inflexibility and functional impairments (Serrano-Guerrero et al, 2020). Previous studies reported altered connectivity underlying MMN in psychotic disorders (Dima et al, 2012;Ranlund et al, 2016;Braeutigam et al, 2018). However, MMN does not highlight the dynamical mechanism to clarify its reduction in psychotic disorders.…”

Section: Discussionmentioning

confidence: 97%

Criticality in the Healthy Brain

Shi

Kirihara

Tada

et al. 2022

Front. Netw. Physiol.

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The excellence of the brain is its robustness under various types of noise and its flexibility under various environments. However, how the brain works is still a mystery. The critical brain hypothesis proposes a possible mechanism and states that criticality plays an important role in the healthy brain. Herein, using an electroencephalography dataset obtained from patients with psychotic disorders (PDs), ultra-high risk (UHR) individuals and healthy controls (HCs), and its dynamical network analysis, we show that the brain of HCs remains around a critical state, whereas that of patients with PD falls into more stable states. Meanwhile, the brain of UHR individuals is similar to that of PD in terms of entropy but is analogous to that of HCs in causality patterns. These results not only provide evidence for the criticality of the normal brain but also highlight the practicability of using an analytic biophysical tool to study the dynamical properties of mental diseases.

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Section: Discussionmentioning

confidence: 97%

Criticality in the Healthy Brain

Shi

Kirihara

Tada

et al. 2022

Front. Netw. Physiol.

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“…This association by latency and approximate source location suggests that DBS influences a cascade of neuronal mechanism related to primary and secondary visual processing, stimulus evaluation and categorization, selective attention, visual working memory, and semantic processing. Evoked amplitudes are reduced in a variety of mental disorders compared to neuro-typical development (Godier et al, 2016 ; Braeutigam et al, 2018 ; Ahtam et al, 2020 ; Hiluy et al, 2021 ; Romero Frausto et al, 2021 ) and DBS may restore a kind of “normality” at the neuronal level. This notion is in line with the hypothesis that electrical neuromodulation shifts abnormal circuits toward a more normative physiological state (Lee et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Magnetoencephalographic Study of the Effects of Deep Brain Stimulation on Neuronal Dynamics in Severe Anorexia Nervosa

Braeutigam

Scaife

Aziz

et al. 2022

Front. Behav. Neurosci.

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Anorexia Nervosa (AN) is a debilitating psychiatric disorder characterized by the relentless pursuit of thinness, leading to severe emaciation. Magnetoencephalography (MEG)was used to record the neuronal response in seven patients with treatment-resistant AN while completing a disorder-relevant food wanting task. The patients underwent a 15-month protocol, where MEG scans were conducted pre-operatively, post-operatively prior to deep brain stimulation (DBS) switch on, twice during a blind on/off month and at protocol end. Electrodes were implanted bilaterally into the nucleus accumbens with stimulation at the anterior limb of the internal capsule using rechargeable implantable pulse generators. Three patients met criteria as responders at 12 months of stimulation, showing reductions of eating disorder psychopathology of over 35%. An increase in alpha power, as well as evoked power at latencies typically associated with visual processing, working memory, and contextual integration was observed in ON compared to OFF sessions across all seven patients. Moreover, an increase in evoked power at P600-like latencies as well as an increase in γ-band phase-locking over anterior-to-posterior regions were observed for high- compared to low-calorie food image only in ON sessions. These findings indicate that DBS modulates neuronal process in regions far outside the stimulation target site and at latencies possibly reflecting task specific processing, thereby providing further evidence that deep brain stimulation can play a role in the treatment of otherwise intractable psychiatric disorders.

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“…The MMN is a negative-going peak reflecting the differences between scalp-level ERP responses to deviant vs. standard stimuli measured across a 135-205-ms time window and thought to reflect an automatic deviance detection process. Several studies have reported large effect sizes for MMN differences between schizophrenia patients and controls using electroencephalography (EEG;Hermens et al, 2010;Javitt et al, 1995;Koshiyama et al, 2017Koshiyama et al, , 2018bKoshiyama et al, , 2018cLight and Braff, 2005;Rasser et al, 2011;Salisbury et al, 2017;Wynn et al, 2010) or magnetoencephalography (Braeutigam et al, 2018;Yamasue et al, 2004), and these findings have been confirmed by several meta-analyses (Erickson et al, 2016;Umbricht and Krljes, 2005); These impairments are among the most consistently replicated findings in schizophrenia research (Keshavan et al, 2008;Näätänen et al, 2019). Many studies have also identified important associations between MMN and cognition (Koshiyama et al, 2018c;Rissling et al, 2014;Toyomaki et al, 2008;Wynn et al, 2010), negative symptoms and functional outcomes (Koshiyama et al, 2018c;Light and Braff, 2005;Rissling et al, 2014) in schizophrenia patients.…”

Section: Introductionmentioning

confidence: 89%

Unique contributions of sensory discrimination and gamma synchronization deficits to cognitive, clinical, and psychosocial functional impairments in schizophrenia

Koshiyama

Miyakoshi

Michael

et al. 2020

Preprint

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BackgroundSchizophrenia patients show widespread deficits in neurocognitive, clinical and psychosocial functioning. Mismatch negativity (MMN) and gamma-band auditory steady-state response (ASSR) are robust biomarkers for domains of neuropsychiatric disorders that are impaired in schizophrenia patients and are separately associated with cognitive dysfunction, negative symptom severity and psychosocial disability. Although these measures of early auditory information processing are conceptually linked, it is unclear, whether these measures are redundant or account for unique variance in important outcome measures. In this study, we aimed to determine whether MMN and gamma-band ASSR are associated with cognitive, clinical, and functional variables and, if so, whether they account for shared vs. non-shared variance in those important domains.MethodsMultiple regression analyses with MMN, gamma-band ASSR and clinical measures were performed in large cohorts of schizophrenia outpatients (N=428) and healthy comparison subjects (N=283).ResultsReduced MMN (d = 0.67), gamma-band ASSR (d = –0.40), and lower cognitive function were confirmed in schizophrenia patients compared to healthy comparison subjects. Regression analyses revealed that both MMN and gamma-band ASSR have significant unique associations with tasks measuring of working memory, and daily functioning in schizophrenia patients.ConclusionThese findings suggest that MMN and ASSR measures are non-redundant and complementary measures. Studies are needed to clarify the neural substrates of MMN and gamma-band ASSR in order to improve our understanding of pathophysiology of schizophrenia and accelerate their use in the development of novel therapeutic interventions.

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Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study

Abstract: This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent

Cited by 19 publications

References 45 publications

Criticality in the Healthy Brain

Criticality in the Healthy Brain

A Longitudinal Magnetoencephalographic Study of the Effects of Deep Brain Stimulation on Neuronal Dynamics in Severe Anorexia Nervosa

Unique contributions of sensory discrimination and gamma synchronization deficits to cognitive, clinical, and psychosocial functional impairments in schizophrenia

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