Dissociation Between Changes in Intramyocardial Function and Left Ventricular Volumes in the Eight Weeks After First Anterior Myocardial Infarction

Kramer, Christopher M.; Rogers, W. Todd; Theobald, Therese M.; Power, Thomas P.; Geskin, Gennady; Reichek, Nathaniel

doi:10.1016/s0735-1097(97)00406-3

Cited by 55 publications

(33 citation statements)

References 42 publications

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“…However, we believe that the converse is also true, that acute ischemic injury, to the extent that it involves myocardial stunning, would likely feature some LV dilation/shape distortion that is reversible. In fact, serial noninvasive imaging studies such as those performed by Kramer et al 26 using magnetic resonance imaging demonstrate that, compared with their acute MI study, a certain percentage of patients will have a reduction in EDV index at follow-up performed 1 year later. One interpretation of these data is that the mechanisms that contribute to acute, reversible LV dilation and dysfunction in SCM may also be operative in some patients with acute ischemic injury.…”

Section: Discussionmentioning

confidence: 95%

Systolic and Diastolic Mechanics in Stress Cardiomyopathy

et al. 2014

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Background-Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental mechanistic differences between SCM and MI would be associated with different systolic and diastolic properties.

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Section: Discussionmentioning

confidence: 95%

Systolic and Diastolic Mechanics in Stress Cardiomyopathy

et al. 2014

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“…This required matching of regions within the LV between weeks 1 and 7. Intrinsic cardiac landmarks were used to maintain registration as previously reported by Kramer et al 19 However, changes in LV shape or volume between imaging sessions could affect the precision of the match. Technical constraints limited MRI contrast imaging to a single image plane.…”

Section: Study Limitationsmentioning

confidence: 99%

Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

et al. 1999

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Background-We have observed 3 abnormal patterns on contrast-enhanced MRI early after reperfused myocardial infarction (MI): (1) absence of normal first-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenhanced signal on delayed images (HYPER), or (3) both absence of normal first-pass enhancement and delayed hyperenhancement (COMB). This study examines the association between these patterns in the first week after MI and late recovery of myocardial contractile function by use of magnetic resonance myocardial tissue tagging. Methods and Results-Seventeen patients (14 men) with a mean age of 53Ϯ12 years were studied after a reperfused first MI. Contrast-enhanced images were acquired immediately after bolus administration of gadolinium and 7Ϯ2 minutes later. Tagged images were acquired at weeks 1 and 7. Circumferential segment shortening (%S) was measured in regions displaying HYPER, COMB, or HYPO contrast patterns and in remote regions (REMOTE) at weeks 1 and 7. At week 1, %S was depressed in HYPER, COMB, and HYPO (9Ϯ8%, 7Ϯ6%, and 5Ϯ4%, respectively) and were less than REMOTE (18Ϯ6%, PϽ0.003). However, in HYPER, %S improved at week 7 from 9Ϯ8% to 18Ϯ5% (PϽ0.001 versus week 1). In contrast, HYPO did not improve significantly (5Ϯ4% to 6Ϯ3%, PϭNS) and COMB tended to improve 7Ϯ6% to 11Ϯ6% (Pϭ0.06). Conclusions-HYPER

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“…This is most likely related to variations in the severity and extent of myocardial injury that is induced by coronary ligation in mouse models (15,23,28,29). The ability in such preclinical models to predict at an early stage whether a sufficient infarction has been induced to result in significant delayed remodeling would be invaluable in improving the design, throughput, and efficiency of such studies.In clinical practice, the prediction of delayed cardiac remodeling is an important aim that aids decisions regarding early therapy (8,10,16). Many different methods of such prediction have been studied among which imaging modalities such as cardiac magnetic resonance imaging (MRI), which provide accurate and reproducible assessment of functional and volumetric parameters of the left ventricle in vivo, are considered especially promising (2, 6, 9, 13, 16).…”

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confidence: 99%

“…In clinical practice, the prediction of delayed cardiac remodeling is an important aim that aids decisions regarding early therapy (8,10,16). Many different methods of such prediction have been studied among which imaging modalities such as cardiac magnetic resonance imaging (MRI), which provide accurate and reproducible assessment of functional and volumetric parameters of the left ventricle in vivo, are considered especially promising (2, 6, 9, 13, 16).…”

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confidence: 99%

MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction

Protti

Dong²,

Sirker³

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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Protti A, Dong X, Sirker A, Botnar R, Shah AM. MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction. Am J Physiol Heart Circ Physiol 303: H309 -H314, 2012. First published May 25, 2012; doi:10.1152/ajpheart.00208.2012 results in adverse cardiac remodeling leading to heart failure and increased mortality. Experimental mouse models of MI are extensively used to identify mechanisms underlying adverse remodeling, but the extent of remodeling that occurs may be highly variable and can limit the utility to discover new disease pathways. The ability to predict the development of significant late post-MI remodeling would be invaluable in conducting such studies by increasing throughput and efficiency. This study aimed to identify potential thresholds of cardiac magnetic resonance imaging (MRI) parameters measured early after murine MI that would predict the development of significant adverse remodeling at 4 wk. MI was achieved by permanent coronary ligation and animals (n ϭ 84) were followed up for 4 wk subsequently. MRI was used to assess left ventricular (LV) volumes, mass and ejection fraction, as well as infarct size (IS). Late gadolinium enhancement cine-MRI was performed at 2 days with standard cine-MRI at 30 days post-MI. Utilizing multiple logistic regression, we found that IS Ͼ36%, at 2 days post-MI, was the overall best single predictor of adverse remodeling at 30 days (sensitivity 80.7%, specificity 88.9%; C-statistic of 0.939 from receiver-operating curve analysis). LV end-systolic volume (LVESV) Ͼ32 l was also an excellent predictor comparable to IS. The combination of IS Ͼ36% and/or LVESV Ͼ32 l provided the highest predictive values for late adverse remodeling among multiple predictors. This study demonstrates that MRIbased estimation of IS and ESV during the acute phase of murine MI are good predictors of subsequent adverse remodeling that may aid experimental design. remodeling prediction; magnetic resonance imaging; infarct size; ejection fraction MYOCARDIAL INFARCTION (MI) is commonly followed by adverse left ventricular (LV) remodeling involving significant changes in LV geometry and function (4). Such adverse remodeling contributes to impaired cardiac function and is a major cause of heart failure and increased mortality (25). Experimental models of MI, for example, as induced by permanent coronary ligation in gene-modified mice, are extensively utilized to elucidate pathophysiological and molecular mechanisms underlying cardiac remodeling that could be therapeutically targeted (5,17,18,22,23,27). The extent of adverse remodeling that occurs after experimental MI in murine models, as manifest by an increase in LV end-diastolic and end-systolic volumes (LVEDV and LVESV, respectively) and a reduction in ejection fraction (EF), can be highly variable and can limit their utility to discover new disease pathways (23,29). This is most likely related to variations in the severity and extent of myocardial injury that is induced by coronary ligation in mouse models (15,23,28,2...

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Dissociation Between Changes in Intramyocardial Function and Left Ventricular Volumes in the Eight Weeks After First Anterior Myocardial Infarction

Cited by 55 publications

References 42 publications

Systolic and Diastolic Mechanics in Stress Cardiomyopathy

Systolic and Diastolic Mechanics in Stress Cardiomyopathy

Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction

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