2019
DOI: 10.1016/j.mvr.2019.103909
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Dissociation between macro- and microvascular parameters in the early phase of hemorrhagic shock

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Cited by 7 publications
(11 citation statements)
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“…A total of 19 vasoactive agents were tested, of which six (32%) restored blood flow following hemorrhagic shock and fluid resuscitation (Figure 4, Table ) 19,42,52‐55 . Eleven vasoactive agents (58%) did not affect blood flow 19,22,56‐60 . The remaining two studies (10%) reported a decrease in blood flow, 61 or results varied markedly between organs 20 .…”
Section: Resultsmentioning
confidence: 99%
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“…A total of 19 vasoactive agents were tested, of which six (32%) restored blood flow following hemorrhagic shock and fluid resuscitation (Figure 4, Table ) 19,42,52‐55 . Eleven vasoactive agents (58%) did not affect blood flow 19,22,56‐60 . The remaining two studies (10%) reported a decrease in blood flow, 61 or results varied markedly between organs 20 .…”
Section: Resultsmentioning
confidence: 99%
“…Other non‐fluid‐based agents with vasoactive properties showed conflicting results. Neither vasopressors 20,57,60,61 nor vasodilators 42,55,59,60 were effective in the preclinical setting. One of the studies investigating the effect of vasopressin reported a decrease in blood flow and an increase in capillary leak as a result of the given treatment, 61 while another study reported no effect of vasopressin on blood flow 57 .…”
Section: Discussionmentioning
confidence: 99%
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“…[ 13 ] Although sodium lactated Ringer’s solution (LRS) avoided the hyperchloremia, it reportedly had the potential of aggravating the shock-induced lactic acidosis. [ 14 ] The lactate in LRS and the acetate in Sodium acetate Ringer’s liquid require metabolism in the liver, [ 15 , 16 ] and in the setting of shock and a traumatized liver, may only exacerbate the problem. [ 17 ] Sodium bicarbonate Ringer’s solution is a new formulation of crystalloid solution composed of sodium, magnesium, potassium, and calcium ions.…”
Section: Introductionmentioning
confidence: 99%
“…19,42,52,53,54,55 Eleven vasoactive agents (58%) did not affect blood flow. 19,22,56,57,58,59,60 The remaining two studies (10%) reported a decrease in blood flow 61 , or results varied markedly between organs. 20 Vasopressin showed contrasting results with a decrease in intestinal blood flow 61 , but no effect on dorsal blood flow.…”
Section: Endothelial Barrier Function (N = 2)mentioning
confidence: 99%