Dissolution and processing of silk fibroin for materials science

Wang, Haiyan; Zhang, Yu‐Qing; Wei, Zheng-Guo

doi:10.1080/07388551.2020.1853030

Cited by 45 publications

(23 citation statements)

References 109 publications

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“…The pore size and microstructures can be effectively controlled by adjusting the freezing temperature or silk fibroin concentration. Moreover, aligned scaffolds can be obtained by controlling the frozen conditions [2,3,[82][83][84][85]. Besides these conventionally used methods, Guo et al recently fabricated silk fibroin-based bulk materials including bars, rods, plates, tubes with caps, and screws with tunable mechanical properties via thermal processing for medical device applications.…”

Section: B Mori Silk Fibroin Materials Fabricationmentioning

confidence: 99%

“…In addition, it has also been used for surgical sutures since ancient times due to its biocompatibility, biodegradability, and non-immunogenicity. Nowadays, silk sutures are used primarily for eye and lip surgery, intraoral surgery, and some skin wounds, mainly because of their excellent handling and tying capabilities [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Silk fi broins are composed of bundles of nanofi brils, which are oriented parallel to the axis of the fi laments. The strong interaction between the twisted bundles of nanofi brils is the origin of the excellent mechanical strength of the B. mori silk [2,3]. As the major component of B. mori silk, the primary structure of silk fi broin consists of H-L chain blocks of hydrophobic heavy chains (H-fi broin, approximately 391 kDa) and hydrophilic light chains (L-chain, approximately 26 kDa) linked together by disulfi de bonds and glycoprotein P25 (approximately 25.2 kDa) tied to the H-L chain blocks through hydrophobic reactions [5].…”

Section: Introductionmentioning

confidence: 99%

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Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

Wang

Zhou

et al. 2023

AUTEX Research Journal

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Natural silk fiber derived from the Bombyx mori (B. mori) silkworm has long been used as a luxury raw material in textile industry because of its shimmering appearance and durability, and as surgical suture for its high strength and flexibility. Regenerated silk fibroin, as the main protein extracted from the cocoons of the B. mori silkworm, recently has gained considerable attention due to its outstanding properties, including facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization. Tremendous effort has been made to fabricate silk fibroin into various promising materials with controlled structural and functional characteristics for advanced utilities in a multitude of biomedical applications, flexible optics, electronics devices, and filtration systems. Herein, reverse engineered silk fibroin extraction methods are reviewed, recent advances in extraction techniques are discussed. Fabrication methods of silk fibroin materials in various formats are also addressed in detail; in particular, progress in new fabrication technologies is presented. Attractive applications of silk fibroin-based materials are then summarized and highlighted. The challenges faced by current approaches in production of silk fibroin-based materials and future directions acquired for pushing these favorable materials further toward above mentioned applications are further elaborated.

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Section: B Mori Silk Fibroin Materials Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

Wang

Zhou

et al. 2023

AUTEX Research Journal

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“…Unfortunately, these solvents are hazardous and tend to be environmentally unfriendly [116]. Furthermore, they can directly affect the characteristics of SF and particularly impact the mechanical properties of the resulting silk biomaterials in subsequent processing [117,118]. The classical regeneration of SF largely includes the use of toxic organic solvents, including calcium chloride/formic acid [106][107][108][109], hexafluoroisopropanol (HFIP) [110][111][112], lithium salt solutions such as lithium thiocyanate (LiSCN) [113] and lithium bromide (9.3 M LiBr-H 2 O) [114] and calcium nitrate/methanol (Ca(NO 3 ) 2 )/CH 3 OH) mixtures [115].…”

Section: Sf As a Green Materialsmentioning

confidence: 99%

Section: Sf As a Green Materialsmentioning

confidence: 99%

The Contribution of Silk Fibroin in Biomedical Engineering

Lujerdean

Baci

Cucu

et al. 2022

Insects

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Silk fibroin (SF) is a natural protein (biopolymer) extracted from the cocoons of Bombyx mori L. (silkworm). It has many properties of interest in the field of biotechnology, the most important being biodegradability, biocompatibility and robust mechanical strength with high tensile strength. SF is usually dissolved in water-based solvents and can be easily reconstructed into a variety of material formats, including films, mats, hydrogels, and sponges, by various fabrication techniques (spin coating, electrospinning, freeze-drying, and physical or chemical crosslinking). Furthermore, SF is a feasible material used in many biomedical applications, including tissue engineering (3D scaffolds, wounds dressing), cancer therapy (mimicking the tumor microenvironment), controlled drug delivery (SF-based complexes), and bone, eye and skin regeneration. In this review, we describe the structure, composition, general properties, and structure–properties relationship of SF. In addition, the main methods used for ecological extraction and processing of SF that make it a green material are discussed. Lastly, technological advances in the use of SF-based materials are addressed, especially in healthcare applications such as tissue engineering and cancer therapeutics.

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Biodegradable Materials for Transient Organic Transistors

Stephen

Nawaz

Lee

et al. 2022

Adv Funct Materials

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Electronic devices that can physically disappear in a controlled manner without harmful by-products unveil a wide range of opportunities in medical devices, environmental monitoring, and next-generation consumer electronics. Their property of transience is indispensable for mitigating the global problem of electronic waste accumulation. Additionally, transient technologies that are biocompatible and can be biologically resorbed are of great potential for applications in temporary medical implants, since it eliminates the need for expensive device recovery surgery. Transistors are the key building blocks of modern electronics, and their fabrication using organic materials is beneficial due to their low cost, unprecedented flexibility and facile processing. This contribution reviews the technological application of biodegradable materials in four major classes of organic transistors, namely organic field-effect transistors (OFETs), organic synaptic transistors, electrolyte-gated OFETs, and organic electrochemical transistors. The fundamental biodegradation mechanism is discussed in detail, followed by a perspective of various biodegradable materials utilized as active semiconductors, dielectrics, electrolytes and substrates in the various types of organic transistor devices. This contribution comprehensively discusses the role and application of biodegradable materials in all of the key modern-day organic transistors, highlighting their unique properties that allow the fabrication of biodegradable, eco-friendly, and sustainable devices.

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Dissolution and processing of silk fibroin for materials science

Cited by 45 publications

References 109 publications

Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

The Contribution of Silk Fibroin in Biomedical Engineering

Biodegradable Materials for Transient Organic Transistors

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