Dissolution behavior and bioavailability of cimetidine-HCl (cimetidine monohydrochloride monohydrate)

A dynamic thermal ATR-FTIR/chemometric approach to the analysis of polymorphic interconversions. Cimetidine as a model drug

“…Interestingly, only three polymorphs were detected in a solvent screen including over 100 different conditions [32], while some published powder diffractograms still cannot be clearly attributed to specific crystal modifications [19]. The polymorphs differ in their bioavailability properties, principally due to their differences in dissolution rates [33][34][35]; however, in pharmaceutical formulations only modifications A and B are used [26]. Forms A, C, D and M1 have been resolved by X-ray crystallography [18,[36][37][38].…”