Dissolution Difference between Acidic and Neutral Media of Acetaminophen Tablets Containing a Super Disintegrant and a Soluble Excipient. II.

Chen, Chun-Ren; Cho, Shu-Ling; Lin, Chih-Kuang; Lin, Yaw-Hung; Chiang, Shu-Tuan; Wu, Hsueh-Ling S.

doi:10.1248/cpb.46.478

Cited by 8 publications

(2 citation statements)

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“…The overall goal is to achieve the product performance robustness by minimizing the dissolution differences caused by process conditions. In previous studies, dissolution differences were found to be largely related to the hydrophobicity of active ingredients 14 or main excipients. Interestingly, dissolution differences have been found to increase when multiple excipients are mixed with an active ingredient 14 .…”

Section: Introductionmentioning

confidence: 95%

“…In previous studies, dissolution differences were found to be largely related to the hydrophobicity of active ingredients 14 or main excipients. Interestingly, dissolution differences have been found to increase when multiple excipients are mixed with an active ingredient 14 . In addition, the type of shear mixer was also found to affect drug dissolution 15 .…”

Section: Introductionmentioning

confidence: 95%

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Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions

Pingali

Méndez

Lewis

et al. 2010

Drug Development and Industrial Pharmacy

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Objective-The purpose of this study was to investigate the effect of mechanical shear on hydrophobicity of pharmaceutical powder blends as a function of composition and particle size, and to determine the impact on drug release from tablets.Methods-Four powder formulations were subjected to three different shear strain conditions (40 rev, 160 rev, and 640 rev) in a controlled shear environment operating at a shear rate of 80 rpm. A total of 12 blends were tested for hydrophobicity. Subsequently, sheared blends were compressed into tablets at 8 kN and 12 kN in a rotary tablet press. During tablet compression, powder samples were collected after the feed frame and their hydrophobicity was again measured.Results-Results indicated that increase in shear strain could significantly increase hydrophobicity, predominantly as an interacting function of blend composition. Blends with both colloidal silica and magnesium stearate (MgSt) were found to show higher hydrophobicity with shear than other blends. Additional shear applied by the tablet press feed frame was found to change the powder hydrophobicity only in the absence of MgSt.Conclusions-Studies showed that the drug release rates dropped with shear more for the blends with both colloidal silica and MgSt than the other blends. Furthermore, the rate of drug release dropped with a decrease in particle size of the main excipient. Surprisingly, the relationship between the relative increase in hydrophobicity and a corresponding drop in the drug release rate was not found when either MgSt or colloidal silica was mixed alone in the blends.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions

Pingali

Méndez

Lewis

et al. 2010

Drug Development and Industrial Pharmacy

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Dissolution

Tiwary

Sapra

Jain

2010

Pharmaceutical Sciences Encyclopedia

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Modern Auxiliary Substances in Tablet Production: Use of High-Molecular-Weight Compounds for the Development of New Medicinal Forms and Optimization of Technological Processes

Voskoboinikova

Avakyan²,

Sokol’skaya

et al. 2005

Pharm Chem J

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Scientifically justified selection of high-quality auxiliary components in solid dosed medicinal forms, in particular tablets, is an important factor influencing the competitiveness of drugs on the market, which is determined not only by their direction of action and urgent necessity, but also by the quality level and the quality-to-price ratio. An important role in the development of modern high-quality dosed solid medicinal forms and optimization of their production technology is played by high-molecular-weight (HMW) compounds, which make it possible to create preparations with preset biopharmaceutical and technological properties. At present, a new generation of such auxiliary HMW components available from foreign manufacturers is widely used in Russian pharmacy. A broad spectrum of new synthetic polymer matrices intended for the controlled release of parent substances from tablets provides conditions for the optimum realization of biological activity of drugs having various structures and directions of action. The use of crosslinked polymeric superdisintegrants ensures a significant increase in the bioaccessibility of poorly soluble parent substances, while retaining the mechanical properties of tablets on a sufficiently high level. The use of new universal HMW substances as auxiliary components combining several functions also creates prerequisites for optimization of the technological process. An increase in the assortment of auxiliary HMW components provides for the development of tablet production technology and ensures an increase in the quality of products.

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Dissolution Difference between Acidic and Neutral Media of Acetaminophen Tablets Containing a Super Disintegrant and a Soluble Excipient. II.

Cited by 8 publications

References 1 publication

Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions

Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions

Dissolution

Modern Auxiliary Substances in Tablet Production: Use of High-Molecular-Weight Compounds for the Development of New Medicinal Forms and Optimization of Technological Processes

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