Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using UV Spectrophotometric Method

Kumar, Chinmoy; Kumar, Manish; Saini, Vipin; Bhatt, Shailendra; Pandurangan, A. G.; Malik, Anuj; Pal, Preeti; Shetty, Laxmi Narayan

doi:10.5958/0974-360x.2019.00459.1

Cited by 9 publications

(3 citation statements)

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“…The photomultiplier is commonly used as a detector in UV-visible spectrophotometer. The photomultiplier consists of a photo emission cathode, several dynodes and an anode [11,12]. a.…”

Section: Assay Of Amlodipine Tablets By Using Uv Spectrophotometric M...mentioning

confidence: 99%

"Comparative Analytic Study by UV Spectrophotometric, Structural Characterization through Fourier Transformed Infrared Spectroscopy (FTIR) Method and Disintegration Analysis for Different Brands of Amlodipine Tablets Available in Malaysia"

Hasan Khan

2023

BJSTR

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Background: To evaluate the percentage purity of different brands of amlodipine tablets available in local market by using UV-Spectrophotometric method and structural characterization through FTIR Spectroscopy.Objective(s): Quantitative determination of different brands of amlodipine tablets available in Malaysia by using UV spectrophotometric and Fourier transform infrared red spectroscopy method. To provide simple and cost-effective spectrophotometric method for quantitative analysis.Material And Methods: For UV-spectrophotometric method, the amlodipine sample was treated with methanol as a solvent. For structural characterization method, amlodipine powdered sample was placed onto the crystal plate and scanned by using spectrum software. Disintegration tester was used for amlodipine tablets. The temperature of the distilled water was maintained at 37˚C (±1˚C).Results and Discussion: For UV-Spectrophotometric method, the samples D and E had passed the limit specified by British Pharmacopoeia (B.P), whereas sample D, E, F, G and H had passed the limit specified by United State Pharmacopeia (U.S.P). For structural characterization, the functional groups of alkynes, alkanes, alkenes and organic halides were present in all the amlodipine samples with the respective wavelength number. A total of eight brands of amlodipine tablets were used in the research. All the different brands of amlodipine tablets were disintegrated within15 minutes. This indicated that the amlodipine tablets can be rapidly absorbed through oral route. Conclusion:The brand D was the best pure, while brand A showed poor purity of drug among all other eight brands of Amlodipine tablets. The assay of the pharmaceutical products should be always performed to ensure the product was maintained in safety, quality, quantity and efficacy condition. All the brands of amlodipine tablets with a temperature of 37˚C (±1˚C) disintegrated within 15 minutes and results showed that the orally taken drug can be easily disintegrated into human body.

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“…The photomultiplier is commonly used as a detector in UV-visible spectrophotometer. The photomultiplier consists of a photo emission cathode, several dynodes and an anode [11,12]. a.…”

Section: Assay Of Amlodipine Tablets By Using Uv Spectrophotometric M...mentioning

confidence: 99%

"Comparative Analytic Study by UV Spectrophotometric, Structural Characterization through Fourier Transformed Infrared Spectroscopy (FTIR) Method and Disintegration Analysis for Different Brands of Amlodipine Tablets Available in Malaysia"

Hasan Khan

2023

BJSTR

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“…Spectrophotometric methods for the determination of ramipril in dosage forms are described in the scientific literature; however, the described approaches are somewhat outdated, which is related to the year of publication of the scientific research data [23][24][25][26]. Spectrophotometric methods for the determination of ramipril in recent years are based on UV spectrophotometric determination [27][28][29][30]. Therefore, the aim of our work was to develop a two simple, rapid, economic, alternative spectrophotometric methods for the determination of ramipril in tablets based on the reaction with sulfonephthalein dye (bromphenol blue (BPB) and cresol red (CR)).…”

Section: Introductionmentioning

confidence: 99%

Two masterful alternative spectrophotometric methods for the determination of ramipril in tablets

Typlynska,

Horyn,

Kucher

et al. 2024

ScienceRise: Pharmaceutical Science

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The aim of the work was to develop two simple, rapid, economic, alternative spectrophotometric methods for the determination of ramipril in tablets based on the reaction with sulfonephthalein dyes (bromphenol blue (BPB) and cresol red (CR)). Materials and methods. Analytical instrumentation: Shimadzu UV-1800 double beam UV-VIS spectrophotometer (Japan) with attached UV-Probe ver. 2.62 software, RAD WAG AS 200/C precise analytical balance (Poland). Ramipril (purity ≥98 % (HPLC)) was purchased from AARTI Industries Limited (India). Ramipril tablets 5 mg and 10 mg were purchased from a local pharmacy. Results and discussion. Two spectrophotometric methods for the determination of ramipril in tablets have been developed. We have tested various sulfophthalein dyes (BPB, bromocresol green, bromthymol blue, thymol blue, CR) in order to choose the optimal for the method development. According to the results of the experimental studies, we chose BPB and CR as reagents, and the solvent was acetonitrile for both methods. The optimal conditions for the quantitative determination of ramipril in tabletsy using BPB were established: dye concentration - 2.35×10-4 mol/L, volume of BPB solution – 1.0 ml, without heating, wavelength – 598 nm, reaction time – 5 min, temperature of the solution – 25 °C. The optimal conditions for the quantitative determination of ramipril in tabletsusing CR were established: dye 1.33×10-4 mol/L, volume of CR solution – 1.0 ml, without heating, wavelength – 395 nm, reaction time – 5 min, temperature of the solution – 25 °C. The spectrophotometric method by using BPB was linear in the concentration range of 1.99-5.96 µg/mL, LOD – 0.20 µg/mL, LOQ – 0.60 µg/mL. The spectrophotometric method using CR was linear in the concentration range of 0.42-5.44 µg/mL, LOD – 0.10 µg/mL, and LOQ – 0.36 µg/mL. The results of the study on robustness, accuracy, and precision were within the acceptance criteria. The results of studying the «greenness» of both methods indicate an excellent «green» analysis.Conclusions. Developed methods can be used as an alternative method for the routine analysis of ramipril tablets

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“…The literature survey showed a UV spectrophotometric method 29 as well as HPLC methods 30,31 for simultaneous estimation of NEB and TEL in their co-formulated tablets.…”

mentioning

confidence: 99%

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

Salim

Radwan

Hadad

et al. 2023

Sci Rep

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Telmisartan (TEL) and Nebivolol (NEB) are frequently co-formulated in a single dosage form that is frequently prescribed for the treatment of hypertension, moreover, telmisartan is currently proposed to be used to treat COVID19-induced lung inflammation. Green rapid, simple, and sensitive synchronous spectrofluorimetric techniques for simultaneous estimation of TEL and NEB in their co-formulated pharmaceutical preparations and human plasma were developed and validated. Synchronous fluorescence intensity at 335 nm was used for TEL determination (Method I). For the mixture, the first derivative synchronous peak amplitudes (D1) at 296.3 and 320.5 nm were used for simultaneous estimation of NEB and TEL, respectively (Method II). The calibration plots were rectilinear over the concentration ranges of 30–550 ng/mL, and 50–800 ng/mL for NEB and TEL, respectively. The high sensitivity of the developed methods allowed for their analysis in human plasma samples. NEB`s Quantum yield was estimated by applying the single-point method. The greenness of the proposed approaches was evaluated using the Eco-scale, National Environmental Method Index (NEMI), and Green Analytical Procedure Index (GAPI) methods.

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Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using UV Spectrophotometric Method

Cited by 9 publications

References 0 publications

"Comparative Analytic Study by UV Spectrophotometric, Structural Characterization through Fourier Transformed Infrared Spectroscopy (FTIR) Method and Disintegration Analysis for Different Brands of Amlodipine Tablets Available in Malaysia"

"Comparative Analytic Study by UV Spectrophotometric, Structural Characterization through Fourier Transformed Infrared Spectroscopy (FTIR) Method and Disintegration Analysis for Different Brands of Amlodipine Tablets Available in Malaysia"

Two masterful alternative spectrophotometric methods for the determination of ramipril in tablets

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

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