Dissolution of Short and Long Rockwool and Glasswool Fibers by Macrophages in Flowthrough Cell Culture

Luoto, Kirsi; Holopainen, Mikko; Kangas, Juhani; Kalliokoski, Pentti; Savolainen, Kai

doi:10.1006/enrs.1997.3825

Cited by 28 publications

(17 citation statements)

References 32 publications

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“…Therefore the International Agency for Research on Cancer (IARC) has reevaluated mineral fibres in 2001 and considers mineral wool fibres, glass wool and stone wool not classifiable as to its carcinogenicity to humans (group 3). Luoto et al 2 also report a method in which macrophages and fibres are placed on a membrane through which culture medium is allowed to flow, and dissolution rates of silica, alumina and iron oxides are measured.…”

Section: Introductionmentioning

confidence: 97%

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Correlation between in vitro and in vivo dissolution behaviour of stonewools by nonlinear modelling techniques

Bulsari¹,

Bergman

Eusch³

et al. 2007

Journal of the European Ceramic Society

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Section: Introductionmentioning

confidence: 97%

“…[1][2][3][4][5][6] These are supposed to reflect the biosolubility in the lungs. The Directive 97/69/EC on the Classification, Packaging and Labelling of Dangerous Substances put mineral wools in carcinogenic category 3 but included exoneration criteria based on composition, biopersistence and dimensions.…”

Section: Introductionmentioning

confidence: 99%

Correlation between in vitro and in vivo dissolution behaviour of stonewools by nonlinear modelling techniques

Bulsari¹,

Bergman

Eusch³

et al. 2007

Journal of the European Ceramic Society

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“…Therefore the long term effect of stone-wool on the lungs was studied. Further data on its direct toxic effects in pneumocytes and alveolar macrophages (Luoto et al, 1998;Marks-Konczalik et al, 1998) are scarce and there is only inadequate evidence for carcinogenicity of stone-wool in humans (IARC, 2002).…”

Section: Introductionmentioning

confidence: 98%

The effect of stone-wool on rat lungs and on the primary culture of rat alveolar macrophages and type II pneumocytes

et al. 2005

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The effect of stone-wool has been studied in both in vivo long term sequential and in vitro methods in male Sprague-Dawley rats. Stone-wool was administered by single intratracheal instillation and the lungs were examined after 1, 3 and 6 months of exposure by morphological methods. UICC crocidolite was applied as a positive control. In addition, the effects of both fibres were examined in primary cultures of alveolar macrophages (AM) and type II pneumocytes (T2) by morphological, biochemical and immunological methods. By the end of 6 months stone-wool induced moderate pulmonary interstitial inflammation and fibrosis without progression, whereas crocidolite induced progressive interstitial inflammation and fibrosis as a function of time. Although stone-wool inhibited phagocytosis, it did not induce serious membrane damage to the cells examined and did not destroy their ultrastructure. It significantly reduced the activity of Cu,Zn/superoxide dismutase (SOD) and alkaline phosphatase (AP) in alveolar macrophages and significantly decreased the activity of AP and gamma-glutamyl transpeptidase (GGT) in type II pneumocytes. Crocidolite, on the other hand, decreased the activity of all enzymes (glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Rd) of glutathione metabolism as well as alkaline phosphatase in alveolar macrophages. It decreased the activity of all enzymes in type II pneumocytes, except for Cu,Zn/SOD. On exposure to stone-wool, the production of inflammatory proteins, macrophage chemoattractant protein-1 (MCP-1) and macrophage inhibitory protein-1alpha (MIP-1alpha) increased in both cultured cells but did not reach the level induced by crocidolite. Our results suggested that stone-wool is less toxic than crocidolite. Whether it is carcinogenic or not, is still an open question.

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“…As características termo-acústicas levam a uma grande procura por parte das indús-trias mínero-metalúrgicas para seu uso em revestimentos de distribuidores, muflas, fornos de aquecimentos e de outros setores como os mercados de construção civil, automotivo, eletro-eletrônico (Luoto et al, 1998).…”

Section: Introductionunclassified

Pozolanicidade dos resíduos industriais, lã de vidro e lã cerâmica

Evangelista

Tenório

Oliveira

2012

Rem: Rev. Esc. Minas

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ResumoAs fibras cerâmicas se caracterizam por ser um material leve, com alto grau de pureza, baixo armazenamento de calor, baixa condutividade térmica, resistência a choque térmico e alta resistência à corrosão em altas temperaturas. Essas característi-cas levam a uma grande procura das indústrias mínero-metalúrgicas e de outros setores para revestimentos de distribuidores, muflas, fornos de aquecimentos, entre outros. Após utilização no processo, por perderem sua capacidade de isolamento, os resíduos gerados precisam de destinação. Esse trabalho enfoca, especificamente, resíduos de lã cerâmica e lã de vidro. Pelo fato de a composição das fibras cerâmicas ser rica em sílica e alumina, efetuou-se uma investigação acerca da atividade pozolânica das mesmas com a cal e o cimento, especificamente CPV ARI, CPII E32 e CPIII 32RS, para avaliação da perspectiva de reciclagem em possível incorporação no concreto. Palavras

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Dissolution of Short and Long Rockwool and Glasswool Fibers by Macrophages in Flowthrough Cell Culture

Cited by 28 publications

References 32 publications

Correlation between in vitro and in vivo dissolution behaviour of stonewools by nonlinear modelling techniques

Correlation between in vitro and in vivo dissolution behaviour of stonewools by nonlinear modelling techniques

The effect of stone-wool on rat lungs and on the primary culture of rat alveolar macrophages and type II pneumocytes

Pozolanicidade dos resíduos industriais, lã de vidro e lã cerâmica

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