Dissolution parameters for sodium diclofenac-containing hypromellose matrix tablet

Mourão, Samanta Cardozo; Silva, Cristiane da; Bresolin, Tania Mari Bellé; Serra, C H R; Porta, Valentina

doi:10.1016/j.ijpharm.2009.11.022

Cited by 23 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug release from HPMC systems has been reported to be influenced by polymer concentration, drug: polymer ratio, polymer particle size, and the polymer's degree of substitution [11]. The decrease observed in drug release in our study as HPMC content increased, is likely due to increase in the viscosity of the polymer gel leading also to a longer diffusional path.…”

Section: Drug Releasementioning

confidence: 45%

Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Âkbari¹,

Enayatifard²,

Saeedi³

et al. 2011

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

Section: Drug Releasementioning

confidence: 45%

Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Âkbari¹,

Enayatifard²,

Saeedi³

et al. 2011

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…">Information about the release rate of the drug from the sustained‐release pharmaceutical form. In vitro dissolution assays using the United States Pharmacopeia (USP) methods are able to provide information about the type of release and the mechanisms involved 13 …”

Section: Methodsmentioning

confidence: 99%

Optimization of Release Kinetics from Sustained-Release Formulations using Model-Independent Pharmacokinetic Simulation

Maderuelo¹,

Zarzuelo

Lanao

2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…The dissolution test was performed on a Hanson Research SR8PLUS automatic dissolution system (Chatsworth, CA, USA) using previously filtered and degassed simulated gastric fluid (SGF) as the dissolution media, prepared as recommended by USP 34. Dissolution profiles were compared by model-independent and modeldependent methods (Mourao et al, 2010).…”

Section: Tablet Characterizationmentioning

confidence: 99%

Preparation and scale up of extended-release tablets of bromopride

Ferreira

Silva

Fraga

et al. 2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop mathematical models to standardize the scale up of this formulation, controlling weight and hardness of the tablets during manufacture according to the USP 34 th edition. DOE studies were conducted using Minitab ™ software. Different excipient combinations were evaluated in order to produce bromopride sustained-release matrix tablets. In the scale-up study, data were collected and variations in tableting machine parameters were measured. Data were processed by Minitab ™ software, generating mathematical equations used for prediction of powder compaction behavior, according to the settings of the tableting machine suitable for scale-up purposes. Bromopride matrix tablets with appropriate characteristics for sustained release were developed. The scale-up of the formulation with the most suitable sustained release profile was established by using mathematical models, indicating that the formulation can be a substitute for the pellets currently marketed.Uniterms: Bromopride/extended-release tablets/preparation. Design of experiments. Extended-release tablets/scale up obtention. Direct compression. Tablets/kinetics release.A reprodutibilidade do processo de fabricação de comprimidos e o controle das suas propriedades farmacotécnicas depende da otimização dos aspectos de formulação e dos parâmetros de processo. O planejamento de experimentos como o Desenho de Experimentos (DOE) pode ser utilizado para acelerar a produção desta formulação, em particular, para a obtenção de comprimidos de liberação prolongada. Formulações de bromoprida são comercializadas sob a forma de péletes de liberação prolongada, o que torna o produto caro e de difícil fabricação. O objetivo deste estudo foi preparar novas formulações de bromoprida de liberação prolongada na forma de comprimidos e desenvolver modelos matemáticos visando ao escalonamento destas formulações, controlando o peso e a dureza dos comprimidos durante a fabricação, de acordo com a 34ª Edição da USP. Estudos de DOE foram realizados utilizando o software Minitab™. Diferentes combinações de excipientes foram avaliadas visando à obtenção dos comprimidos de liberação prolongada de bromoprida. No estudo de scale-up, coletaram-se e mediu-se a influência das variações nos parâmetros da máquina de compressão. Processaram-se os dados obtidos pelo software Minitab ™, gerando equações matemáticas aptas para a previsão do comportamento de compactação do pó em escala industrial. Os comprimidos obt...

show abstract

Dissolution parameters for sodium diclofenac-containing hypromellose matrix tablet

Cited by 23 publications

References 27 publications

Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Optimization of Release Kinetics from Sustained-Release Formulations using Model-Independent Pharmacokinetic Simulation

Preparation and scale up of extended-release tablets of bromopride

Contact Info

Product

Resources

About