Dissolution rate measurement by an automated dialysis method

Barzilay, R B; Hersey, John A.

doi:10.1111/j.2042-7158.1968.tb09888.x

Cited by 14 publications

(6 citation statements)

References 14 publications

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“…The apparatus used and method have previously been described (Barzilay & Hersey, 1968). In most cases the results given there are also used in the present discussion.…”

Section: Experimental a N D Resultsmentioning

confidence: 99%

“…Integration of equation (13) using the limits t = 0, B = 0 gives (14) in equation (5) Fig. 1B shows that the lag time, T, for attainment of this asymptotic value for the sulphathiazole powder is 105 min due to dialysis and pumping rates chosen (Barzilay & Hersey, 1968). Substitution of the measured concentration 4.6 mg/100 ml at time T in equation (20) using the values for solubility, C,, 97.7 mg/100 ml and flow rate F of 2.90 ml min-l and specific surface area, So, 2000 cm2 g1 (i.e.…”

Section: Comparison Of Equations (2) and (3)mentioning

confidence: 98%

“…In a previous communication (Barzilay & Hersey, 1968) an automated dialysis method of measuring dissolution profiles of tablets was described. In common with other dialysis methods (Ferrari & Khoury, 1967;Marlowe & Shangraw, 1967;Krogerus, Kristoffersson & KeheIa, 1967) dissolution rate is not measured directly.…”

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confidence: 99%

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Dissolution rates of sparingly soluble tablets

Hersey

Barzilay

1969

Journal of Pharmacy and Pharmacology

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The automated dialysis method offers an opportunity for the accurate evaluation of the dissolution rates of sparingly soluble dosage forms. By the analysis of kinetic models, the dissolution rates for disintegrating and non‐disintegrating dosage forms may be calculated. The theory is used to examine the effect of additives and compression force on the dissolution rates of sulphathiazole tablets. At the fairly low compression forces used (640–1430 kg) the dissolution rate gradually increases due to penetration of the tablet by the dissolution medium. Polyethylene oxide causes an initial rapid increase in dissolution rate, but the formation of a mucilaginous film results in a constant rate. Using starch, dissolution rate increases rapidly as a result of tablet disintegration. This disintegration is shown to make available less than half the surface area of the original powder. The dissolution rate constant for sulphathiazole under the experimental conditions is 2–75 × 10−4 cm min−1.

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“…The apparatus used and method have previously been described (Barzilay & Hersey, 1968). In most cases the results given there are also used in the present discussion.…”

Section: Experimental a N D Resultsmentioning

confidence: 99%

Section: Comparison Of Equations (2) and (3)mentioning

confidence: 98%

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Dissolution rates of sparingly soluble tablets

Hersey

Barzilay

1969

Journal of Pharmacy and Pharmacology

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“…An automated dialysis method of Barzilay & Hersey (1968) was used with slight modification permitting manual stirring to overcome the constant problem of agglomeration and insufficient exposure of the surface of microcapsule in the dialysis membrane. The temperature of the system was maintained at 37 sf: 0.5 "C. The quantity of clofibrate or chlor-0.…”

Section: In-vitro Release Measurementsmentioning

confidence: 99%

Physical factors affecting microencapsulation by simple coacervation of gelatin

Siddiqui

Taylor

1983

Journal of Pharmacy and Pharmacology

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Gelatin has been coacervated at 60 degrees C using sodium sulphate. Interfacial tensions between coacervate and supernatant liquid, coacervate and two oils (with and without one of two drugs, clofibrate and chlormethiazole) and supernatant liquid and the oils (+/- drug) have been measured by a drop volume technique, in the presence and absence of one of three surfactants, cetrimide, sodium lauryl sulphate and hexadecyltrimethylammonium lauryl sulphate (double salt). Spreading coefficients calculated from tensions indicate that coacervate should spread readily over oil droplets in presence of double salt, less readily with cetrimide and spreading is unlikely in the presence of sodium lauryl sulphate. The sign of the charge on coacervate droplets and oil droplets was identified under different conditions and showed coacervate droplets and oil droplets have opposite charges except in the presence of sodium lauryl sulphate. Microcapsules were prepared using cetrimide or 'double salt' as emulsifier and release of drug measured. Those prepared with 'double salt' released more slowly than those prepared with cetrimide.

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“…USP 1 and 2 apparatuses [20]), (c) forced-convection sink methods (e.g. the dialysis method of Barzilay and Hersey [21]), and (d) continuousflow/flow-through methods (e.g. Langenbucher method [22]).…”

Section: Apparatus Selectionmentioning

confidence: 99%

Profiling in vitro drug release from subcutaneous implants: a review of current status and potential implications on drug product development

Iyer¹,

Barr²,

Karnes³

2006

Biopharm & Drug Disp

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This review presents current methods and strategies for studying the release characteristics of drugs from subcutaneous implant dosage forms. Implants are dosage forms that are subcutaneously placed with the aid of surgery or a hypodermic needle, and are designed to release drugs over a prolonged period of time. In most cases, the objective of a release test is to identify sufficiently discriminatory procedures that in turn would provide data to set meaningful specifications. Additional information obtained from successful in vitro-in vivo correlations (IVIVC) and accelerated drug release tests are extremely useful during drug product development.Although several workers have employed different methods to monitor drug release from these dosage forms, the use of the compendial Apparatus 4 (flow-through) device has been recommended in a publication on FIP/AAPS Guidelines for drug release testing of modified release dosage forms. However, most of method development with this device has focused on oral immediate or controlled release dosage forms and little published information is available on implants. Two recent reports on workshops provide useful information on methods to evaluate drug release from controlled-release parenterals such as implants, including IVIVC and accelerated release testing. Details on such studies, however, are generally not found in the literature; possibly because of the high proprietary value of methodologies for establishing release specifications of implant dosage forms. This article reviews the current status of methodologies used in the investigation of drug release from subcutaneous implants with an emphasis on mechanistic, product development and regulatory perspectives.

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Dissolution rate measurement by an automated dialysis method

Cited by 14 publications

References 14 publications

Dissolution rates of sparingly soluble tablets

Dissolution rates of sparingly soluble tablets

Physical factors affecting microencapsulation by simple coacervation of gelatin

Profiling in vitro drug release from subcutaneous implants: a review of current status and potential implications on drug product development

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