Distal Aortic Perfusion and Theophylline in the Augmentation of Postischemic Renal Blood Flow

Abstract

continued) Renal ischemia was measured by using serum urea nitrogen, serum creatinine, and urine alpha glutathione-S-transferase (alpha-GST).Postclamp renal blood flow measurements were standardized as a percentage of preclamp renal blood flow. Treatment with either distal perfusion or distal perfusion with theophylline demonstrated increased renal blood flow in comparison to the controls (p < 0.001). Pulsatile perfusion with theophylline was superior to pulsatile perfusion alone (p < 0.023). Pulsatile perfusion with theophylline was superior to nonpulsatile perfusion with theophylline (p < 0.030). Creatinine 6 hours postoperative showed a significant decrease with both forms of distal aortic perfusion when compared to the control groups (p = 0.002). Creatinine values at 18 hours postoperative were not significant (p = 0.237). Serum urea nitrogen values at 6 (p = 0.239) and 18 (p = 0.460) hours postoperative were not significant. Alpha-GST values at 6 (p = 0.034) and 18 (p = 0.035) hours postoperative showed a significant difference between the control and treatment groups.Pulsatile distal aortic perfusion with theophylline is superior to nonpulsatile distal aortic perfusion with theophylline in augmenting renal blood flow following renal ischemia in the porcine model.