Distant metastasis in head and neck squamous cell carcinoma variants: A population‐based study

Takenaka, Yukinori; Uno, Atsuhiko; Tanaka, Hidenori; Takemoto, Norihiko; Inohara, Hidenori

doi:10.1002/hed.27305

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Considering the other histological subtypes of OSCC, few studies report them. Therefore, it is difficult to compare it with similar databases, establishing extremely rare histological variables with similar behaviour to conventional OSCC (Takenaka et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Gilligan,

Panico,

Lazos

et al. 2023

Oral Diseases

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ObjectiveTo determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America.MethodsA retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential‐OSCC versus OSCC‐de novo (OSCC‐dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t‐test, and qualitative variables with chi‐square.ResultsIn total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC‐dn, while s‐OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD.ConclusionsIn Latin America, OSCC‐dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

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Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Gilligan,

Panico,

Lazos

et al. 2023

Oral Diseases

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Changes in serum lactate dehydrogenase as a prognostic factor in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors

Lee,

Takenaka,

Hosokawa

et al. 2024

Acta Oto-Laryngologica

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Validation and comparison of prognostic scoring systems in patients with head and neck squamous cell carcinoma treated with nivolumab

Takenaka,

Takemoto,

Otsuka

et al. 2024

Japanese Journal of Clinical Oncology

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Objective Several scoring systems have been developed to predict prognosis in patients with refractory cancer. We aimed to validate eight scoring systems and determine the best method for predicting the prognosis of head and neck squamous cell carcinoma treated with nivolumab. Methods This multicentre retrospective study involved 154 patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with nivolumab between 2017 and 2020. Oncological outcomes were assessed according to the scoring systems, including MD Anderson Cancer Center + neutrophil-to-lymphocyte ratio and Hammersmith scores. Objective response, overall survival and progression-free survival were evaluated using logistic regression and Cox proportional hazards analyses. Receiver operating curve analysis was used to calculate the area under the curve and estimate the efficacy of each score. Results No significant associations were found between the responses and any score. Seven of the eight scoring systems were associated with disease control (odds ratio, 0.26–0.70). Amongst the eight scoring systems, MD Anderson Cancer Center + neutrophil-to-lymphocyte ratio showed the highest area under the curve for predicting response and disease control. Seven scoring systems were prognostic factors for progression-free survival (hazard ratio, 1.22–1.95). All eight scoring systems were prognostic factors for overall survival (hazard ratio, 1.62–3.83). According to the time-dependent receiver operating characteristics analysis for overall survival, the Hammersmith scoring system had the best predictive ability at 3 months, and the MD Anderson Cancer Center + neutrophil-to-lymphocyte ratio scoring system had the highest area under the curve between 6 and 24 months. Conclusions MD Anderson Cancer Center + neutrophil-to-lymphocyte ratio and Hammersmith scoring systems were better predictors of prognosis in patients with head and neck squamous cell carcinoma treated with nivolumab.

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Distant metastasis in head and neck squamous cell carcinoma variants: A population‐based study

Cited by 5 publications

References 27 publications

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Changes in serum lactate dehydrogenase as a prognostic factor in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors

Validation and comparison of prognostic scoring systems in patients with head and neck squamous cell carcinoma treated with nivolumab

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