Distant organ metastasis patterns and prognosis of lung adenosquamous carcinoma: a SEER database analysis

Abstract

OBJECTIVES Our purpose is to evaluate the patterns of organ metastasis and the prognosis in lung adenosquamous carcinoma patients with organ metastasis. METHODS We collected the data from the surveillance epidemiology and end results database, covering the period of 2000 to 2018. Cox regression, Kaplan–Meier and log-rank analyses were performed. RESULTS Totally, 2698 patients were enrolled, comprising 851 (31.54%) patients diagnosed with organ metastasis and 2,017 (68.46%) patients without organ metastasis. Patients with distant organ metastasis show a significant decrease in median overall survival. In addition to the aforementioned factors, age over 70 years, male, main bronchus, advanced T stage, larger tumour size, absence of primary tumour surgery, and lack of radiotherapy have all been identified as prognostic indicators associated with a poorer outcome. In terms of treatment options, patients with organ metastasis can benefit from chemotherapy and primary tumour surgery. Moreover, in patients with organ metastasis, those who received a combination treatment of surgery, chemotherapy, and radiotherapy displayed the most favourable prognosis, with a median overall survival of 17 months. CONCLUSIONS We identified the prognostic indicators for organ metastasis in patients with lung adenosquamous carcinoma. Highly selected patients who undergo a combination treatment of surgery, chemotherapy, and radiotherapy may experience the greatest survival benefit.