“…In this heterogeneous patient cohort ranging from mild to very severe COPD, BALF PMN (i.e., neutrophil) MVs strongly correlate with the BODE index as well as multiple other markers of COPD severity: worsening dyspnea score, degree of airway obstruction and hyperinflation, lung parenchymal damage, and exercise tolerance Lucchetti et al, 2021 [ 57 ] | Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients | Investigate whether extracellular vesicles are present and detectable in exhaled breathe condensate (EBC) and to perform a preliminary comparison of their concentrations in COPD and healthy control subjects | Ex vivo Human | Extracellular vesicles are detectable in EBC and sputum and measurement of EBC mEV concentrations might be more informative in COPD patients |
Bazzan et al, 2021 [ 58 ] | Microvesicles in bronchoalveolar lavage as a potential biomarker of COPD | investigate the presence and source of MVs in bronchoalveolar lavage (BAL) of smokers with and without COPD compared with nonsmoking controls | Ex vivo Human | MVs obtained directly from the lung BAL show that, in response to smoking and to the development of COPD, measurable inflammatory signals in alveolar macrophages can be quantified and that their numbers are related to the pack-years and the decrease in lung function |
Carpi et al, 2020 [ 59 ] | Expression analysis of muscle-specific miRNAs in plasma-derived extracellular vesicles from patients with chronic obstructive pulmonary disease | Analyse the expression profiles of EV-derived myo-miRNAs (specifically miR-206, miR-133a-5p, and miR-133a-3p) in plasma samples collected from patients with COPD | Ex vivo Human | Myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate between COPD patients |
Shen et al, 2021 [ 60 ] | A novel diagnostic signature based on three circulating exosomal mircoRNAs for chronic obstructive pulmonary disease | Evaluate differentially expressed exo-miRNAs in the plasma of patients with COPD and healthy individuals for their potential diagnostic value in COPD | Ex vivo Human | The expression levels of three exo-miRNAs (miR-23a, miR-221 and miR-574) were found to be negatively associated with the forced expiratory volume in the 1st second/forced vital capacity. The three circulating exosomal miRNAs may serve as novel circulating biomarkers for the diagnosis of COPD |
Kaur et al, 2021 [ 61 ] | |
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