2021
DOI: 10.3390/ijms222111830
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Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF Patients

Abstract: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are chronic, progressive lung ailments that are characterized by distinct pathologies. Early detection biomarkers and disease mechanisms for these debilitating diseases are lacking. Extracellular vesicles (EVs), including exosomes, are small, lipid-bound vesicles attributed to carry proteins, lipids, and RNA molecules to facilitate cell-to-cell communication under normal and diseased conditions. Exosomal miRNAs have been studi… Show more

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Cited by 46 publications
(36 citation statements)
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“…According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), the current diagnosis of COPD is based on three features including spirometry, observation of symptoms and a significant exposure to toxic stimuli [ 49 ]. Twelve studies [ 50 – 61 ] investigated the use of EVs as a more effective and accurate diagnostic tool for COPD (Table 7 ). All twelve studies involved human studies, with one study [ 53 ] carrying out additional investigation in vitro.…”
Section: Resultsmentioning
confidence: 99%
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“…According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), the current diagnosis of COPD is based on three features including spirometry, observation of symptoms and a significant exposure to toxic stimuli [ 49 ]. Twelve studies [ 50 – 61 ] investigated the use of EVs as a more effective and accurate diagnostic tool for COPD (Table 7 ). All twelve studies involved human studies, with one study [ 53 ] carrying out additional investigation in vitro.…”
Section: Resultsmentioning
confidence: 99%
“…In this heterogeneous patient cohort ranging from mild to very severe COPD, BALF PMN (i.e., neutrophil) MVs strongly correlate with the BODE index as well as multiple other markers of COPD severity: worsening dyspnea score, degree of airway obstruction and hyperinflation, lung parenchymal damage, and exercise tolerance Lucchetti et al, 2021 [ 57 ] Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients Investigate whether extracellular vesicles are present and detectable in exhaled breathe condensate (EBC) and to perform a preliminary comparison of their concentrations in COPD and healthy control subjects Ex vivo Human Extracellular vesicles are detectable in EBC and sputum and measurement of EBC mEV concentrations might be more informative in COPD patients Bazzan et al, 2021 [ 58 ] Microvesicles in bronchoalveolar lavage as a potential biomarker of COPD investigate the presence and source of MVs in bronchoalveolar lavage (BAL) of smokers with and without COPD compared with nonsmoking controls Ex vivo Human MVs obtained directly from the lung BAL show that, in response to smoking and to the development of COPD, measurable inflammatory signals in alveolar macrophages can be quantified and that their numbers are related to the pack-years and the decrease in lung function Carpi et al, 2020 [ 59 ] Expression analysis of muscle-specific miRNAs in plasma-derived extracellular vesicles from patients with chronic obstructive pulmonary disease Analyse the expression profiles of EV-derived myo-miRNAs (specifically miR-206, miR-133a-5p, and miR-133a-3p) in plasma samples collected from patients with COPD Ex vivo Human Myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate between COPD patients Shen et al, 2021 [ 60 ] A novel diagnostic signature based on three circulating exosomal mircoRNAs for chronic obstructive pulmonary disease Evaluate differentially expressed exo-miRNAs in the plasma of patients with COPD and healthy individuals for their potential diagnostic value in COPD Ex vivo Human The expression levels of three exo-miRNAs (miR-23a, miR-221 and miR-574) were found to be negatively associated with the forced expiratory volume in the 1st second/forced vital capacity. The three circulating exosomal miRNAs may serve as novel circulating biomarkers for the diagnosis of COPD Kaur et al, 2021 [ 61 ] …”
Section: Resultsmentioning
confidence: 99%
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“…Of course, the duration of disease and severity of immune responses can directly or indirectly affect exosomal content. In line with this claim, it was determined that the content of miR-122-5p was significantly reduced in bronchoalveolar fluid taken from COPD patients compared to the control group [ 138 ]. Due to the existence of active inflammatory response and recruitment of different immune cells into a pulmonary niche, it is logical to mention that the content of inflammatory Exo are high in inflamed site compared to the systemic circulation.…”
Section: Role Of Exo On the Progression Of Copdmentioning
confidence: 99%
“…A growing body of literature shows that EVs are a key component in the pathobiology of IPF. Those vesicles accumulate in the lungs of patients with IPF [ 164 ], and they harbor specific cargoes of proteins and microRNA [ 164 , 165 , 166 , 167 , 168 , 169 ]. Mechanistically, fibrosis-derived EVs activate the mechanism of fibrosis, such as fibroblast proliferation and activation, by controlling developmental signaling such as Wnt or TGF-β1 [ 164 , 167 ].…”
Section: Extracellular Lipids As Important Regulators Of Fibrosis Pro...mentioning
confidence: 99%