Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster

Gür, Burak; Šporar, Katja; Lopez-Behling, Anne; Silies, Marion

doi:10.1007/s00359-019-01385-7

Cited by 9 publications

(7 citation statements)

References 79 publications

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“…However, L1 calcium signals show a transient and a sustained response component, which are contrast- and luminance-sensitive, respectively. Compared to photoreceptors, which also carry both contrast and luminance components, L1 still amplifies the contrast signals received from the photoreceptors, since its transient component is more pronounced than the one seen in the photoreceptor calcium traces ( Gür et al, 2020 ). In other insect species, different types of lamina neurons have also been distinguished based on their physiological properties ( Rusanen et al, 2018 ; Rusanen et al, 2017 ), although their specific luminance and contrast sensitivities are yet unknown.…”

Section: Discussionmentioning

confidence: 99%

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

Ketkar

Gür

Molina-Obando

et al. 2022

eLife

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The accurate processing of contrast is the basis for all visually guided behaviors. Visual scenes with rapidly changing illumination challenge contrast computation because photoreceptor adaptation is not fast enough to compensate for such changes. Yet, human perception of contrast is stable even when the visual environment is quickly changing, suggesting rapid post receptor luminance gain control. Similarly, in the fruit fly Drosophila, such gain control leads to luminance invariant behavior for moving OFF stimuli. Here we show that behavioral responses to moving ON stimuli also utilize a luminance gain, and that ON-motion guided behavior depends on inputs from three first-order interneurons L1, L2 and L3. Each of these neurons encodes contrast and luminance differently and distributes information asymmetrically across both ON and OFF contrast-selective pathways. Behavioral responses to both ON and OFF stimuli rely on a luminance-based correction provided by L1 and L3, wherein L1 supports contrast computation linearly, and L3 non-linearly amplifies dim stimuli. Therefore, L1, L2 and L3 are not specific inputs to ON and OFF pathways but the lamina serves as a separate processing layer that distributes distinct luminance and contrast information across ON and OFF pathways to support behavior in varying conditions.

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Section: Discussionmentioning

confidence: 99%

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

Ketkar

Gür

Molina-Obando

et al. 2022

eLife

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“…It is not surprising that manipulating ion channel expression affects neural dynamics. In fact, ion channel expression has been shown to regulate neural dynamics in other Drosophila studies (Groschner et al, 2018;Gür et al, 2020), as well as with some timing mechanisms in vertebrate motor control circuits, which can rely on axonal conductance properties to coordinate activity (Egger et al, 2020). However, the method we used in this study to manipulate the dynamics of individual neuron types is a powerful tool for manipulating and dissecting circuit function.…”

Section: Neurons Can Control Their Response Dynamics By Regulating Ion Channel Expressionmentioning

confidence: 99%

Manipulating neural dynamics to tune motion detection

Gonzalez-Suarez

Zavatone-Veth

Chen

et al. 2021

Preprint

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Neurons integrate excitatory and inhibitory signals to produce their outputs, but the role of input timing in this integration remains poorly understood. Motion detection is a paradigmatic example of this integration, since theories of motion detection rely on different delays in visual signals. These delays allow circuits to compare scenes at different times to calculate the direction and speed of motion. It remains untested how response dynamics of individual cell types drive motion detection and velocity sensitivity. Here, we sped up or slowed down specific neuron types in Drosophila’s motion detection circuit by manipulating ion channel expression. Altering the dynamics of individual neurons upstream of motion detectors changed their integrating properties and increased their sensitivity to fast or slow visual motion, exposing distinct roles for dynamics in tuning directional signals. A circuit model constrained by data and anatomy reproduced the observed tuning changes. Together, these results reveal how excitatory and inhibitory dynamics jointly tune a canonical circuit computation.

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“…Compared to photoreceptors, which also carry both contrast and luminance components, L1 still amplifies the contrast signals received from the photoreceptors, since its transient component is more pronounced than the one seen in the photoreceptor calcium traces (Gür et al, 2020). In other insect species, different types of lamina neurons have also been distinguished based on their physiological properties (Rusanen et al, 2018(Rusanen et al, , 2017, although their specific luminance and contrast sensitivities are yet unknown.…”

Section: Neurons Postsynaptic To Photoreceptors Encode Contrast and Luminance Differentlymentioning

confidence: 99%

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

Ketkar

Gür

Molina-Obando

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The accurate processing of contrast is the basis for all visually guided behaviors. Visual scenes with rapidly changing illumination challenge contrast computation, because adaptation is not fast enough to compensate for such changes. Yet, human perception of contrast is stable even when the visual environment is quickly changing. The fruit fly Drosophila also shows nearly luminance invariant behavior for both ON and OFF stimuli. To achieve this, first-order interneurons L1, L2 and L3 all encode contrast and luminance differently, and distribute information across both ON and OFF contrast-selective pathways. Behavioral responses to both ON and OFF stimuli rely on a luminance-based correction provided by L1 and L3, wherein L1 supports contrast computation linearly, and L3 non-linearly amplifies dim stimuli. Therefore, L1, L2 and L3 are not distinct inputs to ON and OFF pathways but the lamina serves as a separate processing layer that distributes distinct luminance and contrast information across ON and OFF pathways to support behavioral performance in varying conditions.

show abstract

Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster

Cited by 9 publications

References 79 publications

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

Manipulating neural dynamics to tune motion detection

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

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