Distinct forelimb and hind limb stepping impairments in unilateral dopamine-depleted rats: use of the rotorod as a method for the qualitative analysis of skilled walking

Whishaw, Ian Q.; Li, Katie; Whishaw, Paul A.; Gorny, Bogdan; Metz, Gerlinde A. S.

doi:10.1016/s0165-0270(03)00049-9

Cited by 37 publications

(31 citation statements)

References 25 publications

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“…However, the 6-OHDA/6-MSITC group displayed a significant reduction in apomorphine-induced rotations as compared to the 6-OHDA/saline group. The rotarod test has been used as a drug free test for unilaterally 6-OHDAlesioned animals to assess akinetic symptoms and may also be used in detecting loss of TH-immunoreactive cells in the SN (Whishaw et al, 2003;Rozas et al, 1997). Our results were in agreement with previous works showing that the time spent on the rotating rod was lower in 6-OHDA-lesioned mice (Didonet et al, 2014;Kopalli et al, 2013;Im et al, 2005), and more interesting, that 6-MSITC treatment significantly improved mice's performance.…”

Section: Discussionsupporting

confidence: 91%

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

Morroni¹,

Sita²,

Tarozzi³

et al. 2014

Brain Research

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Section: Discussionsupporting

confidence: 91%

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

Morroni¹,

Sita²,

Tarozzi³

et al. 2014

Brain Research

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“…Although puzzling, this observation is consistent with reports that unilateral DA depletion also affected posture (Whishaw et al, 2003), stepping time, and stepping length (Olsson et al, 1995) at the ipsilateral paw. Interestingly, when the animal was forced to move (drag test), motor activity at the ipsilateral paw was only slightly impaired, suggesting that the bar and drag test provide information on different aspects of motor program.…”

Section: J-113397/l-dopa Interaction On Behaviorsupporting

confidence: 90%

The Nociceptin/Orphanin FQ Receptor Antagonist J-113397 and l-DOPA Additively Attenuate Experimental Parkinsonism through Overinhibition of the Nigrothalamic Pathway

Marti¹,

Trapella²,

Viaro³

et al. 2007

J. Neurosci.

126

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By using a battery of behavioral tests, we showed that nociceptin/orphanin FQ receptor (NOP receptor) antagonists attenuated parkinsonian-like symptoms in 6-hydroxydopamine hemilesioned rats (Marti et al., 2005). We now present evidence that coadministration of the NOP receptor antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H benzimidazol-2-one (J-113397) and L-DOPA to 6-hydroxydopamine hemilesioned rats produced an additive attenuation of parkinsonism. To investigate the neurobiological substrates underlying this interaction, in vivo microdialysis was used in combination with behavioral measurements (bar test). J-113397 and L-DOPA alone reduced the time on bars (i.e., attenuated akinesia) and elevated GABA release selectively in the lesioned substantia nigra reticulata. J-113397 also reduced nigral glutamate levels, whereas L-DOPA was ineffective. J-113397 and L-DOPA coadministration produced additive antiakinetic effect, which was associated with additive increase in nigral GABA release but no additional reductions in glutamate levels. To investigate whether the increase in nigral GABA release could translate to changes in nigrothalamic transmission, GABA release was monitored in the ventromedial thalamus (one of the main target areas of the nigrothalamic projections). J-113397 and L-DOPA decreased thalamic GABA release and attenuated akinesia, their combination resulting in a more profound effect. These actions were prevented by perfusing the voltage-dependent Na ϩ channel blocker tetrodotoxin or the GABA A receptor antagonist bicuculline in the substantia nigra reticulata. These data demonstrate that J-113397 and L-DOPA exert their antiparkinsonian action through overinhibition of nigrothalamic transmission and suggest that NOP receptor antagonists may be useful as an adjunct to L-DOPA therapy for Parkinson's disease.

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“…Completing others studies that have shown that this technique could also provide a very useful way of examining posture and stepping in brain injured rats (Whishaw et al, 2003). Moreover the protocol used should be selected according to the particular purpose of the experiments.…”

Section: Discussionmentioning

confidence: 98%

Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model

Monville

Torres

Dunnett

2006

Journal of Neuroscience Methods

233

143

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Distinct forelimb and hind limb stepping impairments in unilateral dopamine-depleted rats: use of the rotorod as a method for the qualitative analysis of skilled walking

Cited by 37 publications

References 25 publications

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

The Nociceptin/Orphanin FQ Receptor Antagonist J-113397 and l-DOPA Additively Attenuate Experimental Parkinsonism through Overinhibition of the Nigrothalamic Pathway

Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model

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