Distinct inflammatory mediator patterns in young black and white adults: The African-predict study

Crouch, Simone H.; Roux, Shani Botha-Le; Delles, Christian; Graham, Lesley; Schutte, Aletta E.

doi:10.1016/j.cyto.2019.154894

Cited by 7 publications

(14 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This discrepancy may lie in the fact that most of these other cohorts were examined in relation to cardiovascular‐related disease or events. IFN‐γ was higher among our White study participants, consistent with findings in another study 52 . In contrast, other investigators found that African–American women had significantly higher mean levels of IFN‐γ then White women 70 .…”

Section: Discussionsupporting

confidence: 91%

Inflammatory proteins are associated with mortality in a middle‐aged diverse cohort

Noren Hooten,

Mode,

Allotey

et al. 2023

Clinical & Translational Med

View full text Add to dashboard Cite

BackgroundRecent data indicate a decline in overall longevity in the United States. Even prior to the COVID‐19 pandemic, an increase in midlife mortality rates had been reported. Life expectancy disparities have persisted in the United States for racial and ethnic groups and for individuals living at low socioeconomic status. These continued trends in mortality indicate the importance of examining biomarkers of mortality at midlife in at‐risk populations. Circulating levels of cytokines and inflammatory markers reflect systemic chronic inflammation, which is a well‐known driver of many age‐related diseases.MethodsIn this study, we examined the relationship of nine different inflammatory proteins with mortality in a middle‐aged socioeconomically diverse cohort of African–American and White men and women (n = 1122; mean age = 47.8 years).ResultsWe found significant differences in inflammatory‐related protein serum levels between African–American and White middle‐aged adults. E‐selectin and fibrinogen were significantly higher in African–American adults. IFN‐γ, TNF‐α trimer, monocyte chemoattractant protein‐1 (MCP‐1), soluble receptor for advanced glycation end‐products (sRAGE) and P‐selectin were significantly higher in White participants compared to African–American participants. Higher levels of E‐selectin, MCP‐1 and P‐selectin were associated with a higher mortality risk. Furthermore, there was a significant interaction between sex and IL‐6 with mortality. IL‐6 levels were associated with an increased risk of mortality, an association that was significantly greater in women than men. In addition, White participants with high levels of sRAGE had significantly higher survival probability than White participants with low levels of sRAGE, while African–American participants had similar survival probabilities across sRAGE levels.ConclusionsThese results suggest that circulating inflammatory markers can be utilized as indicators of midlife mortality risk in a socioeconomically diverse cohort of African–American and White individuals.

show abstract

Section: Discussionsupporting

confidence: 91%

Inflammatory proteins are associated with mortality in a middle‐aged diverse cohort

Noren Hooten,

Mode,

Allotey

et al. 2023

Clinical & Translational Med

View full text Add to dashboard Cite

show abstract

“…The black and white groups were similar in age (24.5 years; p = 0.92) with an equal distribution in sex (p = 0.71). When viewing the detailed inflammatory mediator profile of the two groups, the black group had higher pro-to-anti-inflammatory ratios than their white counterparts (p ≤ 0.021) as was seen in a previous study in this population [17]. There were no ethnic differences for Na + excretion (p = 0.47), but black participants had lower urine levels of K + , with 94% black and 88% white participants having K + levels below recommended levels [28].…”

Section: Resultssupporting

confidence: 63%

“…Previous studies also reported a greater proportion of salt sensitivity in black populations [16]. The cardiovascular risk in black populations may be further increased based on their more pro-inflammatory profile when compared to white adults [17].…”

Section: Introductionmentioning

confidence: 82%

“…While numerous studies have examined differences in inflammation between ethnic groups, global findings remain contradictory [34]. However, multiple studies performed in South African populations have found that black individuals display higher levels of pro-inflammatory markers and an overall more pro-inflammatory profile [17,[35][36][37]. When examining Na + , previous studies found that black adults have a predisposition for higher Na + retention [16].…”

Section: Discussionmentioning

confidence: 99%

“…We analysed data of participants who were included in the baseline phase of the African-PREDICT study (n = 1202). This study is a sub-cohort of a previously published larger cohort [17]. Participants on anti-inflammatory medication and with missing biochemical data (Na + , K + , and multiple inflammatory mediators) were additionally excluded resulting in a total of 991 participants.…”

Section: Study Populationmentioning

confidence: 99%

See 2 more Smart Citations

Inflammation and salt in young adults: the African-PREDICT study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Purpose Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K +) intake was found to counter increase in blood pressure due to high salt intake and may potentially also have protective anti-inflammatory effects. To better understand these interactions under normal physiological conditions, we investigated the relationships between 22 inflammatory mediators with 24-h urinary K + in young healthy adults stratified by low, medium and high salt intake (salt tertiles). We stratified by ethnicity due to potential salt sensitivity in black populations. Methods In 991 healthy black (N = 457) and white (N = 534) adults, aged 20-30 years, with complete data for 24-h urinary sodium and K + , we analysed blood samples for 22 inflammatory mediators. Results We found no differences in inflammatory mediators between low-, mid-and high-sodium tertiles in either the black or white groups. In multivariable-adjusted regression analyses in white adults, we found only in the lowest salt tertile that K + associated negatively with pro-inflammatory mediators, namely interferon gamma, interleukin (IL)-7, IL-12, IL-17A, IL-23 and tumour necrosis factor alpha (all p ≤ 0.046). In the black population, we found no independent associations between K + and any inflammatory mediator. Conclusion In healthy white adults, 24-h urinary K + associated independently and negatively with specific pro-inflammatory mediators, but only in those with a daily salt intake less than 6.31 g, suggesting K + to play a protective, anti-inflammatory role in a low-sodium environment. No similar associations were found in young healthy black adults.

show abstract

Non-modifiable and Modifiable Risk Factors in Vascular Ageing Extremes: The African-PREDICT Study

Rooi,

Kruger,

van Vuren

et al. 2024

Artery Res

View full text Add to dashboard Cite

Background Cardiovascular risk factors accelerate vascular ageing beyond chronological age, hence early vascular ageing (EVA). Carotid to femoral pulse wave velocity (cfPWV) is a measure of vascular ageing and is used to identify EVA and supernormal vascular ageing (SUPERNOVA). Vascular ageing is not completely understood in African populations. Therefore, we aimed to phenotype young South African adults stratified by cfPWV extremes in terms of non-modifiable and modifiable risk factors. This study included 1133 young adults (mean age: 24.5 years). We measured cfPWV using applanation tonometry. Body composition measures, self-reported 24-h dietary intake, smoking and alcohol consumption were included. Fasting blood samples were analysed for biochemical risk factors. Three groups based on cfPWV percentiles were compared and included SUPERNOVA (≤ 10th percentile), average vascular ageing (AVA, between 10 to 90th percentile) and EVA (≥ 90th percentile). Results Chronological age, male sex, smoking, alcohol use, and blood pressure were incrementally higher across PWV groups (all p trend ≤ 0.007). Black ethnicity was higher (p = 0.038) in the SUPERNOVA group. In exploratory factor analysis, a factor pattern including mean arterial pressure and fasting glucose showed beneficial odds (OR 0.62, p = 0.002) for SUPERNOVA and higher likelihood (OR 2.10, p < 0.001) for EVA. Another factor pattern of socio-economic status and total dietary fat showed lower odds (OR 0.64, p = 0.003) for EVA. Conclusion Poor lifestyle behavioural risk factors seem detrimental in the EVA group conferring a possible higher risk of future CVD.

show abstract

Distinct inflammatory mediator patterns in young black and white adults: The African-predict study

Cited by 7 publications

References 61 publications

Inflammatory proteins are associated with mortality in a middle‐aged diverse cohort

Inflammatory proteins are associated with mortality in a middle‐aged diverse cohort

Inflammation and salt in young adults: the African-PREDICT study

Non-modifiable and Modifiable Risk Factors in Vascular Ageing Extremes: The African-PREDICT Study

Contact Info

Product

Resources

About