2024
DOI: 10.34133/research.0484
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Distinct Olfactory Bulb-Cortex Neural Circuits Coordinate Cognitive Function in Parkinson’s Disease

Shuai-Shuai Wang,
Xing-Feng Mao,
Zhi-Shen Cai
et al.

Abstract: Cognitive dysfunction stands as a prevalent and consequential non-motor manifestation in Parkinson’s disease (PD). Although dysfunction of the olfactory system has been recognized as an important predictor of cognitive decline, the exact mechanism by which aberrant olfactory circuits contribute to cognitive dysfunction in PD is unclear. Here, we provide the first evidence for abnormal functional connectivity across olfactory bulb (OB) and piriform cortex (PC) or entorhinal cortex (EC) by clinical fMRI, and dys… Show more

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