2005
DOI: 10.1016/j.jmb.2005.09.024
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Distinct Spatial and Temporal Distribution of ZAP70 and Lck following Stimulation of Interferon and T-cell Receptors

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Cited by 15 publications
(20 citation statements)
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“…In our hands, we did not observe Zap70 in raft membranes from CD3/CD28-stimulated Jurkat T cells, as was previously described following anti-CD3 activation alone (1) and reinforced when the CD28 costimulation signal was added (44). The low anti-CD3 concentration we used could in part explain our observation because Ahmed et al (45), using the same anti-CD3 dosage, did not demonstrate Zap70 capping. In addition, the immune status of the cells, i.e., Th1 vs Th2 (46) or naive vs memory cells (47), also influences membrane reorganization of signaling complexes.…”
Section: Discussionsupporting
confidence: 68%
“…In our hands, we did not observe Zap70 in raft membranes from CD3/CD28-stimulated Jurkat T cells, as was previously described following anti-CD3 activation alone (1) and reinforced when the CD28 costimulation signal was added (44). The low anti-CD3 concentration we used could in part explain our observation because Ahmed et al (45), using the same anti-CD3 dosage, did not demonstrate Zap70 capping. In addition, the immune status of the cells, i.e., Th1 vs Th2 (46) or naive vs memory cells (47), also influences membrane reorganization of signaling complexes.…”
Section: Discussionsupporting
confidence: 68%
“…Interferon α-induced nuclear localization of Lck in Jurkat T cells is hypothesized to play a role in differentiating downstream responses of specific extracellular stimuli [25]. It highlights the importance of protein subcellular localization for initiating specific cellular signaling cascades during different physiological events.…”
Section: Resultsmentioning
confidence: 99%
“…We and others have previously demonstrated that IFNαR and TCR are networked such that IFNαR requires a functional TCR as well as Lck, ZAP-70, Vav1 and SLP-76 to induce ERK activation in Jurkat and primary CD4 + T-cells [1,2,5,7]. This has also been demonstrated for CXCR4-mediated ERK activation in Jurkat cells [6].…”
Section: Discussionmentioning
confidence: 59%