Distinction between intraductal carcinoma of the prostate (IDC-P), high-grade dysplasia (PIN), and invasive prostatic adenocarcinoma, using molecular markers of cancer progression

Dawkins, Hugh; Sellner, Loryn N.; Turbett, Gavin R.; Thompson, Colin A.; Redmond, Sharon L.; McNeal, John E.; Cohen, Ronald J.

doi:10.1002/1097-0045(20000901)44:4<265::aid-pros1>3.0.co;2-i

Cited by 104 publications

(68 citation statements)

References 13 publications

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“…4 Histological features of IDC-P have been greatly refined by recent studies (Table 1). 6,7,[10][11][12][13] A typical example of IDC-P comprises many glands, often >6, in an individual radical prostatectomy specimen. 13 IDC-P glands are larger than normal peripheral zone glands, 9,13 and exhibit markedly irregular and branching contours ( Fig.…”

Section: Historical Perspectivementioning

confidence: 99%

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Intraductal carcinoma of the prostate: the whole story

Zhou

2013

Pathology

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Section: Historical Perspectivementioning

confidence: 99%

“…Dawkins et al 11 studied allelic instability (loss of heterozygosity, LOH) in PIN, prostate carcinoma with Gleason patterns 3 and 4, and IDC-P to define the position of IDC-P in prostate carcinoma progression. They observed no LOH in Gleason grade 3 cancers.…”

Section: Molecular Genetics Of Idc-pmentioning

confidence: 99%

Intraductal carcinoma of the prostate: the whole story

Zhou

2013

Pathology

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“…IDC-P on prostate biopsies is frequently associated with high-grade cancer and poor prognostic parameters at radical prostatectomy as well as advanced disease following other therapies [83]. Dawkins et al found that 29% of Gleason pattern 4 cancers and 60% of IDC-P demonstrated loss of heterozygosity (LOH), while LOH was rarely observed in PIN and Gleason pattern 3 adenocarcinoma [85]. Their results indicate that IDC-P is a distinct lesion from high-grade PIN and represents a late event in prostate cancer evolution.…”

Section: High-grade Pin On Turpmentioning

confidence: 99%

Precursor lesions to prostatic adenocarcinoma

Epstein

2008

Virchows Arch

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High-grade prostatic intraepithelial neoplasia (PIN) is the one well-documented precursor to adenocarcinoma of the prostate. This review article defines both low- and high-grade PIN. Unusual variants of high-grade PIN are illustrated. Benign lesions that may be confused with high-grade PIN, including central zone histology, clear cell cribriform hyperplasia, and basal cell hyperplasia are described and illustrated. High-grade PIN is also differentiated from invasive acinar (usual) and ductal adenocarcinoma. The incidence of high-grade PIN, its relationship to carcinoma (including molecular findings), and risk of cancer on rebiopsy are covered in detail. Finally, intraductal carcinoma of the prostate, a controversial entity, is discussed and differentiated from high-grade PIN.

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“…However, it may arise in peripheral prostatic ducts and may be observed on prostate needle biopsy [7,15,17]. Ductal adenocarcinoma of the prostate has an aggressive outcome with a progression rate between Gleason scores 7 and 8 to 9 tumor [2,8,14,18,19].…”

Section: Discussionmentioning

confidence: 97%

“…Dawkins et al [18], using 12 polymorphic microsatellite markers frequently lost in prostate cancers, showed that loss of heterozygosity was infrequent in HG-PIN but usual in ductal adenocarcinoma. However, this method is not amenable to routine performance with limited disease on paraffin-embedded needle-biopsy tissue.…”

Section: Discussionmentioning

confidence: 99%