Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia

Ding, Xin; Cheng, Zhi Ping; Sun, Bin; Huang, Jian; Wang, Liang; Han, Xiang; Yang, Yuanyuan; Xu, Wen; Cao, Xujun; Miao, Po; Wang, Ying; Guo, Wanliang; Gu, Qin; Feng, Xing

doi:10.1016/j.neulet.2015.12.061

Cited by 17 publications

(19 citation statements)

References 26 publications

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“…Our criteria excluded the majority of preterm infants who had a complicated NICU course and who could present with different, and probably more severe, sleep problems often linked to the presence of a severe neurological damage. 49 Despite the fact that no differences in bedtime, rise time, or sleep duration have been found in preterm versus full-term children, the sleep problems described by the parents of preterm children (restlessness, breathing problems during sleep) could have resulted in sleep disruption, which has been associated with alteration of daytime behavior, attention, and learning difficulties during childhood and adolescence as reported in the literature. 50,51 Regarding temperamental characteristics, we showed that preterm children had lower levels of attention and more negative emotionality (eg, crying, stranger wariness) than full-term children.…”

Section: Discussionmentioning

confidence: 98%

Sleep Characteristics and Temperament in Preterm Children at Two Years of Age

Caravale

Sette

Cannoni

et al. 2017

Journal of Clinical Sleep Medicine

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Section: Discussionmentioning

confidence: 98%

Sleep Characteristics and Temperament in Preterm Children at Two Years of Age

Caravale

Sette

Cannoni

et al. 2017

Journal of Clinical Sleep Medicine

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“…Moreover, even with the best care, these children only have little improvement in the overall ability. Accordingly, HIBD is a major public health issue which globally leads to substantial socio-economic burden of the individual, family and healthcare system (Ding et al, 2016). Altogether, efficient pharmacological strategies for the sanitation and therapy of HIBD are restricted by safety and toxicity considerations.…”

Section: Introductionmentioning

confidence: 99%

“…Although the precise pathogenesis of HIBD is still inconclusive, it is valid that oxidative stress, oxidative metabolism and apoptosis are the significant components of cell death following HIBD (Deanna L. Taylor et al, 1999;Ding et al, 2016). Oxidative stress and oxidative metabolism play a pivotal role in the procedure of pathogenesis after the occurrence of HIBD which ultimately trigger cell death.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats

Zhu

et al. 2016

Brain Research Bulletin

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“…Circadian Locomotor Output Cycles Kaput ( CLOCK ) genes are rhythmically expressed in the pineal gland which secretes melatonin and is crucial for regulation of the sleep-wake cycle ( 125 ). Expression of CLOCK is altered following hypoxic-ischaemic brain injury in animal models ( 126 ) and alterations in circadian rhythm have been reported in children following even mild perinatal hypoxic-ischaemia ( 127 ). Day and night variability of melatonin has been found to be lower in children with CP ( 128 ).…”

Section: Respiratory Dysfunctionmentioning

confidence: 99%

Multi-Organ Dysfunction in Cerebral Palsy

et al. 2021

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Cerebral Palsy (CP) describes a heterogenous group of non-progressive disorders of posture or movement, causing activity limitation, due to a lesion in the developing brain. CP is an umbrella term for a heterogenous condition and is, therefore, descriptive rather than a diagnosis. Each case requires detailed consideration of etiology. Our understanding of the underlying cause of CP has developed significantly, with areas such as inflammation, epigenetics and genetic susceptibility to subsequent insults providing new insights. Alongside this, there has been increasing recognition of the multi-organ dysfunction (MOD) associated with CP, in particular in children with higher levels of motor impairment. Therefore, CP should not be seen as an unchanging disorder caused by a solitary insult but rather, as a condition which evolves over time. Assessment of multi-organ function may help to prevent complications in later childhood or adulthood. It may also contribute to an improved understanding of the etiology and thus may have an implication in prevention, interventional methods and therapies. MOD in CP has not yet been quantified and a scoring system may prove useful in allowing advanced clinical planning and follow-up of children with CP. Additionally, several biomarkers hold promise in assisting with long-term monitoring. Clinicians should be aware of the multi-system complications that are associated with CP and which may present significant diagnostic challenges given that many children with CP communicate non-verbally. A step-wise, logical, multi-system approach is required to ensure that the best care is provided to these children. This review summarizes multi-organ dysfunction in children with CP whilst highlighting emerging research and gaps in our knowledge. We identify some potential organ-specific biomarkers which may prove useful in developing guidelines for follow-up and management of these children throughout their lifespan.

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Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia

Cited by 17 publications

References 26 publications

Sleep Characteristics and Temperament in Preterm Children at Two Years of Age

Sleep Characteristics and Temperament in Preterm Children at Two Years of Age

Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats

Multi-Organ Dysfunction in Cerebral Palsy

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