Distinguishing Clinically Important from Unimportant Prostate Cancers Before Treatment

Abstract

Quantitative analysis of systematic biopsy specimens combined with PSA density provides valuable staging information and helps to identify cancers of low biological potential.

Are prostate needle biopsies predictive of the laterality of significant cancer and positive surgical margins?

“…The median (range) number of biopsies taken for each patient was 10.3 (6-24) and the median cores positive for cancer was 2.84 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Unilateral and bilateral nerve-sparing was performed in 70 (14%) and 287 (59%) patients, respectively.…”

“…A focal PSM refers to a solitary site of malignant cells at any inked margin, while extensive PSM refers to multiple sites of involvement. Significant cancer in LRP specimens was defined as cancer of medium or extensive ( > 0.5 mL) volume or any Gleason grade 4 [4][5][6]. The dominant biopsy side was defined as the only prostate lobe with disease for unilaterally positive biopsy cases, and the lobe with the most positive biopsy cores for bilateral cases.…”

Early Prostate-Specific Antigen Relapse after Radical Retropubic Prostatectomy:Prediction on the Basis of Preoperative andPostoperative Tumor Characteristics

“…Preoperative characteristics provide important information for predicting the outcome after RRP [1, 9, 10, 11, 12, 13], but few data are available on the application of multivariate calculations for judging simultaneous effects of these characteristics [14, 15, 16, 17, 18, 19]. Of potential value are the qualitative and quantitative data obtained from preoperative systematic sextant biopsies of the prostate; a classification scheme based on these data combined with other preoperative characteristics might enhance the predictive power for a PSA relapse.…”

Comparative Study of Two Different TRUS–Guided Sextant Biopsy Techniques in Detecting Prostate Cancer in One Biopsy Session

“…In an earlier study [14]it was found that, even when 4 biopsies were obtained from the transition zone, detection of cancers was low. Therefore, and due to the fact that we would need too many biopsy cores, we desisted from taking transition zone biopsies.…”