Distribution and binding pattern of benzo(a)pyrene in rat liver, lung and kidney constituents after oral administration

Yamazaki, Hiroyasu; Terada, Masayuki; Tsuboi, Akira; Matsubara, Chizuyo; Hata, Toshiaki; Kakiuchi, Yasuo

doi:10.1080/02772248709357223

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…Nearly 80% of a gavage dose of 0.0527 mg/kg [14C]benzo[alpyrene in peanut oil was detected in the excreta of rats 48 hours after exposure; however, some of the recovered radioactivity may never have been absorbed by the alimentary tract of the rats, but may have passed into the excreta in the peanut oil (Hecht et al, 1979). Radioactivity found in the liver, lungs, kidneys, and testis following a low dose of [3H]-benzo[a]pyrene to Sprague-Dawley rats provides supporting evidence of oral absorption (Yamazaki and Kakiuchi, 1989;Yamazaki et al, 1987). The extent of oral absorption in rats is enhanced when benzo[a]pyrene is solubilized in a vehicle (triolein, soybean oils, highfat diet) that is readily absorbed following low-and high-dose levels (Kawamura et al, 1988;O'Neill et al, 1991).…”

Section: Absorption Inhalation Exposurementioning

confidence: 70%

“…[3H]-Benzo[a]pyrene distributed to the protein fractions of the liver, lung, and kidney (Yamazaki et al, 1987). The radioactivity in the protein fractions of these tissues increased gradually over time.…”

Section: Oral Exposurementioning

confidence: 96%

“…The increase in protein binding of radioactivity associated with benzo[a]pyrene and its metabolites, and the persistence of the radioactivity associated with the protein fractions, suggests that protein binding may allow benzo[a]pyrene and its metabolites to accumulate in certain tissues, thus increasing the likelihood of cytotoxicity, mutagenicity, or carcinogenicity of benzo[a]pyrene and its metabolites in these organs. In addition, these organs have low metabolic activity while the liver has a high detoxification potential and can facilitate the excretion of these toxic products (Yamazaki et al, 1987).…”

Section: Oral Exposurementioning

confidence: 99%

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Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

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Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such as tobacco and charbroiled meat. There are more than 100 PAHs. PAHs generally occur as complex mixtures (for example, as part of products such as soot), not as single compounds. PAHs are found throughout the environment in the air, water, and soil. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals, including PAHs (ATSDR, 1995), found at facilities on the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). These profiles include information on health effects of chemicals from different routes and durations of exposure, their potential for exposure, regulations and advisories, and the adequacy of the existing database. Assessing the health effects of PAHs is a major challenge because environmental exposures to these chemicals are usually to complex mixtures of PAHs with other chemicals. The biological consequences of human exposure to mixtures of PAHs depend on the toxicity, carcinogenic and noncarcinogenic, of the individual components of the mixture, the types of interactions among them, and confounding factors that are not thoroughly understood. Also identified are components of exposure and health effects research needed on PAHs that will allow estimation of realistic human health risks posed by exposures to PAHs. The exposure assessment component of research should focus on (1) development of reliable analytical methods for the determination of bioavailable PAHs following ingestion, (2) estimation of bioavailable PAHs from environmental media, particularly the determination of particle-bound PAHs, (3) data on ambient levels of PAHs metabolites in tissues/fluids of control populations, and (4) the need for a critical evaluation of current levels of PAHs found in environmental media including data from hazardous waste sites. The health effects component should focus on obtaining information on (1) the health effects of mixtures of PAHs particularly their noncarcinogenic effects in humans, and (2) their toxicokinetics. This report provides excerpts from the toxicological profile of PAHs (ATSDR, 1995) that contains more detailed information.

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Section: Absorption Inhalation Exposurementioning

confidence: 70%

Section: Oral Exposurementioning

confidence: 96%

Section: Oral Exposurementioning

confidence: 99%

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Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

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“…pyrene to Sprague-Dawley rats provides supporting evidence of oral absorption (Yamazaki and Kakiuchi 1989;Yamazaki et al 1987). The extent of oral absorption in rats is enhanced when benzo [a]pyrene is solubilized in a vehicle (triolein, soybean oils, high-fat diet) that is readily absorbed following low-and high-dose levels (Kawamura et al 1988;O'Neill et al 1991).…”

Section: Benzo[b]fluoranthenementioning

confidence: 81%

The Gulf Oil Spill

2011

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“…However, rat studies indicate that benzo(a)pyrene is distributed to the lung, liver, kidney, gastrointestinal tract and carcass after inhalation exposure (Weyand and Bevan 1986, 1987a and to the liver, lung and kidneys after oral exposure (Yamazaki, et al 1987). In animal studies via the dermal route, PAHs can readily penetrate the skin but very little is distributed to tissues.…”

Section: Environmental Fate Characteristicsmentioning

confidence: 99%