Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems

Casals, Eudald; Vázquez‐Campos, Socorro; Bastús, Neus G.; Puntes, Víctor

doi:10.1016/j.trac.2008.06.004

Cited by 129 publications

(90 citation statements)

References 58 publications

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“…Nanoparticles have large surface that helps them react very quick [75]. A metal nanoparticle is an example that they might speed up reactions in living things in unpredictable ways causing illness or death [75,76]. Furthermore, nanoparticles have ability in antimicrobial activities but also they may kill benefit bacterial communities in the intestinal tract.…”

Section: Challenges Of Nanoparticlesmentioning

confidence: 99%

Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

Nguyen

Jovel

Nguyen

2017

Journal of Nanomaterials

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Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.

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Section: Challenges Of Nanoparticlesmentioning

confidence: 99%

Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

Nguyen

Jovel

Nguyen

2017

Journal of Nanomaterials

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“…Fmoc protecting group was cleaved by treatment with a solution of 25% piperidine in DMF. Peptides were cleaved from the resin by treatment with 95% TFA, 2.5% TIS, 2.5% water for 2 h. C(VRLPPP) 3 , was synthesized manually by solid-phase synthesis using the 9-fluorenylmethoxycarbonyl/tert-butyl (Fmoc/tBu) strategy. 2-Ch orotrity resi Nα-Fmoc-protected amino acids (2 equiv)/TBTU(2 equiv) and DIEA(6 equiv) were used.…”

Section: Synthetic Proceduresmentioning

confidence: 99%

“…These results were confirmed by circular dichroism 52 and amino acid analisys. Similarly, the blockage of macrophage immune response towards AuNP-C(VRPPP) 3 -COOH can be explained in terms of the highly packed layers formed by the C(VRPPP) 3 -COOH at Au NP surface. In addition, neither the conjugation of Au NPs to BSA fragments nor the non-specific conjugation of Au NPs to media proteins produce activation of macrophage immune response.…”

Section: The Effect Of the Order In The Peptide Layermentioning

confidence: 99%

“…Despite the remarkable rapidness in the development of strategies for particle synthesis and functionalization as well as the further use of these conjugates in biomedical applications, relatively little is still stated about the interaction of nanoparticles (NPs) with living systems [1][2][3] . This is particularly important for the immune system, which is responsible for maintaining body integrity and preventing external invasion.…”

Section: Introductionmentioning

confidence: 99%

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Inorganic nanoparticles and the immune system: detection, selective activation and tolerance

Bastús

Sánchez-Tilló

Pujals³

et al. 2012

SPIE Proceedings

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The immune system is the responsible for body integrity and prevention of external invasion. On one side, nanoparticles are no triggers that the immune system is prepared to detect, on the other side it is known that foreign bodies, not only bacteria, viruses and parasites, but also inorganic matter, can cause various pathologies such as silicosis, asbestosis or inflammatory reactions. Therefore, nanoparticles entering the body, after interaction with proteins, will be either recognized as self-agents or detected by the immune system, encompassing immunostimulation or immunosuppression responses. The nature of these interactions seems to be dictated not specially by the composition of the material but by modifications of NP coating (composition, surface charge and structure). Herein, we explore the use of gold nanoparticles as substrates to carry multifunctional ligands to manipulate the immune system in a controlled manner, from undetection to immunostimulation. Murine bone marrow macrophages can be activated with artificial nanometric objects consisting of a gold nanoparticle functionalized with peptides. In the presence of some conjugates, macrophage proliferation was stopped and pro-inflammatory cytokines were induced. The biochemical type of response depended on the type of conjugated peptide and was correlated with the degree of ordering in the peptide coating. These findings help to illustrate the basic requirements involved in medical NP conjugate design to either activate the immune system or hide from it, in order to reach their targets before being removed by phagocytes. Additionally, it opens up the possibility to modulate the immune response in order to suppress unwanted responses resulting from autoimmunity, or allergy or to stimulate protective responses against pathogens.

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“…Furthermore, it has been hypothesized that phenomena that operate at low realistic doses are likely to be different from those operating at very high doses when organism or cell defences are overwhelmed (Oberdorster et al, 2005). In addition to that, it is important pointing out that INP's concentration may change in different parts of the body, either by aggregation or accumulation (trapping) in special organs as the liver or kidneys Casals et al, 2008).…”

Section: Reactivity and Sizementioning

confidence: 99%