Distribution of basic fibroblast growth factor in the developing rat brain

Gómez-Pinilla, F; Lee, J.W.-K.; Cotman, Carl W.

doi:10.1016/0306-4522(94)90412-x

Cited by 74 publications

(48 citation statements)

References 36 publications

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“…Although the precise mechanism of action of the tactile stimulation is not known, we hypothesize that tactile stimulation leads to an increase in the production of a neurotrophic factor, FGF-2, in both skin and brain. FGF-2 has previously been found to play an important role in both neurogenesis and neuronal maturation (26,27).…”

Section: Factors Influencing Prefrontal Developmentmentioning

confidence: 99%

Experience and the developing prefrontal cortex

Kolb

Mychasiuk

Muhammad

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

485

321

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The prefrontal cortex (PFC) receives input from all other cortical regions and functions to plan and direct motor, cognitive, affective, and social behavior across time. It has a prolonged development, which allows the acquisition of complex cognitive abilities through experience but makes it susceptible to factors that can lead to abnormal functioning, which is often manifested in neuropsychiatric disorders. When the PFC is exposed to different environmental events during development, such as sensory stimuli, stress, drugs, hormones, and social experiences (including both parental and peer interactions), the developing PFC may develop in different ways. The goal of the current review is to illustrate how the circuitry of the developing PFC can be sculpted by a wide range of pre-and postnatal factors. We begin with an overview of prefrontal functioning and development, and we conclude with a consideration of how early experiences influence prefrontal development and behavior.neural plasticity | dendritic spines | prenatal stress | psychoactive drugs | metaplasticity T he development of the cerebral cortex reflects more than a simple unfolding of a genetic blueprint; rather, it represents a complex dance of experiential and genetic factors that mold the emerging cerebrum. Pre-and postnatal environmental events, such as sensory stimuli, hormones, parent-child relationships, stress, and psychoactive drugs, modify cerebral development and, ultimately, adult behavior. Although all cerebral regions are influenced by early experience, the effects of experience are significantly different in specific cortical regions. The goal of this article is to review the ways in which one specific region, the prefrontal cortex (PFC), is sculpted by a wide range of pre-and postnatal factors. We begin with an overview of the nature and function of the PFC, followed by a review of experience-dependent modification of prefrontal organization and function. What Is the PFC?Kaas (1) proposed that a few basic areas of cerebral cortex are present in all mammals. These include primary and secondary visual and somatosensory areas (i.e., V1, V2, S1, S2), at least one auditory area and one taste area, a motor area, a transitional strip of cortex that relates the amygdala and hippocampus to other cortical areas (i.e., perirhinal cortex, entorhinal cortex), and a region referred to as the PFC. The definition of the sensory regions is relatively straightforward insofar as they receive unimodal input from the sensory receptor systems (e.g., eye, ear, tongue), and the outputs of the motor cortex are ultimately directed via polysynaptic pathways to effector organs. The outputs of all cortical regions are also components of feedback loops through which the cortex and subcortical regions of the brain mutually influence each other. Although there is no universally acceptable definition of the PFC, it can be regarded to be the region of the cortex that receives its principal thalamic inputs from the mediodorsal nucleus of the thalamus (e.g., 2). This cor...

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Section: Factors Influencing Prefrontal Developmentmentioning

confidence: 99%

Experience and the developing prefrontal cortex

Kolb

Mychasiuk

Muhammad

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

485

321

View full text Add to dashboard Cite

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“…As FGF-2 mRNA and proteins have been localized in both neuronal and glial cells (Gomez-Pinilla et al 1994), we investigated whether FGF-2 IRES activity was present in both cell types. First, we measured the IRES activity in a fraction enriched in synaptoneurosomes from P6-P7 transgenic mouse forebrain.…”

Section: Neuronal Localization Of Fgf-2 Ires Activitymentioning

confidence: 99%

Potent activation of FGF-2 IRES-dependent mechanism of translation during brain development

Audigier¹,

Guiramand²,

Prado-Lourenço³

et al. 2008

RNA

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Fibroblast growth factor-2 (FGF-2) plays a fundamental role in brain functions. This role may be partly achieved through the control of its expression at the translational level via an internal ribosome entry site (IRES)-dependent mechanism. Transgenic mice expressing a bicistronic mRNA allowed us to study in vivo and ex vivo where this translational mechanism operates. Along brain development, we identified a stringent spatiotemporal regulation of FGF-2 IRES activity showing a peak at post-natal day 7 in most brain regions, which is concomitant with neuronal maturation. At adult age, this activity remained relatively high in forebrain regions. By the enrichment of this activity in forebrain synaptoneurosomes and by the use of primary cultures of cortical neurons or cocultures with astrocytes, we showed that this activity is indeed localized in neurons, is dependent on their maturation, and correlates with endogenous FGF-2 protein expression. In addition, this activity was regulated by astrocyte factors, including FGF-2, and spontaneous electrical activity. Thus, neuronal IRES-driven translation of the FGF-2 mRNA may be involved in synapse formation and maturation.

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“…In fact, FGF-2 is expressed in the developing brain (Gomez-Pinilla et al 1994;Monfils et al 2006), and it is modulated by dopamine (Fumagalli et al 2003). Further, when administered early in life, it potentiated the acquisition of cocaine self-administration (Turner et al 2009) and enhanced cocaine sensitization at adulthood (Clinton et al 2012).…”

Section: Introductionmentioning

confidence: 98%