Distribution of circulating natural killer cells and T lymphocytes in head and neck squamous cell carcinoma

Böttcher, Arne; Ostwald, Jürgen; Guder, Ellen; Pau, Hans Wilhelm; Kramp, B; Dommerich, Steffen

doi:10.1016/j.anl.2012.07.004

Cited by 11 publications

(14 citation statements)

References 25 publications

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“…Although the classification of tumors has improved our understanding of lung cancer prognosis, immune factors are notably absent in existing prognostic models of lung cancer (26). This omission is significant both because immune evasion is a recognized hallmark of cancer (27) and because of the abundant evidence that patients with lung and aerodigestive cancer suffer systemic immune defects (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46), a portion of which are now known to respond to immunotherapy (47,48). Blood lymphocyte counts (particularly CD4 T-cells) and T-cell function are altered in patients with cancer, with Tregulatory cells having been of significant interest to date in the literature (30,38,40,42,45,46).…”

Section: Host Immunity Has a Significant Effect On Cancer Survivalmentioning

confidence: 99%

“…Several studies have reported that the increased frequency of T-regulatory CD4 1 lymphocytes in the peripheral circulation correlates with prognosis (49)(50)(51). In addition to the inhibitory signaling alterations mediated by T-regulatory cells that are associated with cancers, it is also clear that natural killer cells play an important role in aerodigestive cancers (32,38,52). In addition to mediating direct cytotoxicity, they participate in the regulation of the antitumorous adaptive immune response, as they produce cytokines such as interferon-g, tumor necrosis factor-a, interleukin-10, several chemokines, and growth factors.…”

Section: Host Immunity Has a Significant Effect On Cancer Survivalmentioning

confidence: 99%

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Immunomethylomics: A Novel Cancer Risk Prediction Tool

Kelsey¹,

Wiencke

2018

Annals ATS

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There is emerging evidence that the immune biology associated with lung and other solid tumors, as well as patient immune genetic traits, contributes to individual survival. At this time, dramatic advances in immunologic approaches to the study and management of human cancers are taking place, including lung and head and neck squamous cell carcinoma. However, major obstacles for therapies are the profound immune alterations in blood and in the tumor microenvironment that arise in tandem with the cancer. Although there is a significant current effort underway across the cancer research community to probe the tumor environment to uncover the dynamics of the immune response, little similar work is being done to understand the dynamics of immune alterations in peripheral blood, despite evidence showing the prognostic relevance of the neutrophil/lymphocyte ratio for these cancers. A prominent feature of cancer-associated inflammation is the generation of myeloid-derived suppressor cells, which arise centrally in bone marrow myelopoiesis and peripherally in response to tumor factors. Two classes of myeloid-derived suppressor cells are recognized: granulocytic and monocytic. To date, such immune factors have not been integrated into molecular classification or prognostication. Here, we advocate for a more complete characterization of patient immune profiles, using DNA from archival peripheral blood after application of methylation profiling (immunomethylomics). At the heart of this technology are cell libraries of differentially methylated regions that provide the "fingerprints" of immune cell subtypes. Going forward, opportunities exist to explore aberrant immune profiles in the context of cancer-associated inflammation, potentially adding significantly to prognostic and mechanistic information for solid tumors.

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Section: Host Immunity Has a Significant Effect On Cancer Survivalmentioning

confidence: 99%

Section: Host Immunity Has a Significant Effect On Cancer Survivalmentioning

confidence: 99%

Immunomethylomics: A Novel Cancer Risk Prediction Tool

Kelsey¹,

Wiencke

2018

Annals ATS

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“…They found that TINK cells expressed higher mRNA levels of the NKG2A inhibitory receptor, granzymes A and K, Fas, CXCR5, and CXCR6 compared to nontumoral NK cells, but had lower expression of CX3CR1 and S1PR1 [19]. In another study, gene expression profiling of circulating NK cells in head and neck squamous cell carcinoma patients revealed that NK cells from head and neck squamous cell carcinoma patients who had not received any therapy exhibited some downregulated receptors (CCR7, CXCR3, IL-7R) compared with expression in healthy subjects; these receptors were then upregulated upon treatment [18]. These data indicate that TINK cells exhibit a specific modulation of the expression of chemokine receptors involved in cell migration within the tumor microenvironment.…”

Section: Nk Cells In the Tumor Microenvironmentmentioning

confidence: 99%

“…For example, recent large‐scale microarray analysis of immune cells, including NK cells, T cells, invariant NKT cells, and DCs, shows that lymphocyte differentiation, activation, and function are accompanied by simultaneous changes in hundreds of genes . Moreover, transcriptional changes were identified in malignant and immune disorders, including lymphoma, leukemia, rheumatoid arthritis, systemic lupus erythematosus, and many others .…”

Section: Introductionmentioning

confidence: 99%

Genomic expression profiling of NK cells in health and disease

2014

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NK cells are important components of innate and adaptive immunity. Functionally, they play key roles in host defense against tumors and infectious pathogens. Within the past few years, genomic-scale experiments have provided us with a plethora of gene expression data that reveal an extensive molecular and biological map underlying gene expression programs. In order to better explore and take advantage of existing datasets, we review here the genomic expression profiles of NK cells and their subpopulations in resting or stimulated states, in diseases, and in different organs; moreover, we contrast these expression data to those of other lymphocytes. We have also compiled a comprehensive list of genomic profiling studies of both human and murine NK cells in this review.

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“…Plusieurs auteurs ont montré une diminution du nombre de cellules NK dans le sang [4,6,7]. À l'inverse, les équipes de Böttcher et al et de Millrud et al, en 2012, décrivaient une augmentation de ces cellules dans le sang de ces patients [4,8]. La diminution des cellules NK dans le sang des patients semble être un facteur de mauvais pronostic de survie [9].…”

Section: Réponses Immunitaires Anti-tumoralesunclassified

Immunité et cancers des voies aéro-digestives supérieures 1^re partie : Réponses immunitaires et échappement tumoral

Lescaille

Rochefort

Macedo

et al. 2014

Med Buccale Chir Buccale

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-Les cancers des voies aéro-digestives supérieures (VADS) sont un problème de santé publique majeur. Chez l'homme, ces cancers arrivent en troisième place en termes de fréquence en France. Le pronostic est sombre, la survie des patients ne dépasse pas 20 % à 10 ans. Il est nécessaire de s'intéresser à l'environnement tumoral, afin de mieux comprendre les étapes de formation et d'extension, ainsi que les interactions avec le système immunitaire de l'hôte. L'identification de nouveaux biomarqueurs, témoins du processus cancéreux mais aussi d'une éventuelle réponse immunitaire anti-tumorale pourraient constituer des éléments du diagnostic et du pronostic, mais aussi des cibles thérapeutiques. Cette revue de la littérature a pour but de faire le point sur la réponse immunitaire et l'échappement tumoral des cancers des VADS.

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Distribution of circulating natural killer cells and T lymphocytes in head and neck squamous cell carcinoma

Cited by 11 publications

References 25 publications

Immunomethylomics: A Novel Cancer Risk Prediction Tool

Immunomethylomics: A Novel Cancer Risk Prediction Tool

Genomic expression profiling of NK cells in health and disease

Immunité et cancers des voies aéro-digestives supérieures 1^re partie : Réponses immunitaires et échappement tumoral

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Distribution of circulating natural killer cells and T lymphocytes in head and neck squamous cell carcinoma

Cited by 11 publications

References 25 publications

Immunomethylomics: A Novel Cancer Risk Prediction Tool

Immunomethylomics: A Novel Cancer Risk Prediction Tool

Genomic expression profiling of NK cells in health and disease

Immunité et cancers des voies aéro-digestives supérieures 1re partie : Réponses immunitaires et échappement tumoral

Contact Info

Product

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Immunité et cancers des voies aéro-digestives supérieures 1^re partie : Réponses immunitaires et échappement tumoral