Distribution of Coding Apoptotic Gene Polymorphisms in Women with Extreme Phenotypes of Breast Cancer Predisposition and Tolerance

Abstract

Coding apoptotic gene polymorphisms do not play a major role in BC predisposition. The results of this investigation may be considered while designing future studies on breast cancer-associated candidate SNPs.

Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population

“…However, we did not find any association of DR4 rs20575 polymorphism with the GBC risk. Our results are in agreement with other studies showing null association of rs20575 with lung cancer [28], breast cancer [10], [25], [42], [45], bladder cancer [19], and gastric cancer [43], [50]. In our meta-analysis also, we didn't find any association with cancer risk.…”

“…We combined the results of our study with the rest 12 eligible studies [10], [19], [21], [22], [25], [28], [40]–[42], [45], [46] to calculate pooled OR for 4731 cases/5029 control and found no significant overall association with risk of cancer [C vs. G: OR = 1.05 (0.97–1.12), p = 0.222; CC vs. GG: OR = 1.07 (0.94–1.22), p = 0.291; CG vs. GG: OR = 1.08 (0.92–1.27), 0.352; CC+CG vs. GG: OR = 1.09 (0.94–1.26), p = 0.268; Table 6 and Figure S1 in File S1]. On subgroup analysis, no significant association was found amongst any groups after ethnicity or cancer site based subgroupings.…”

“…For rs20576, 8 studies were found eligible [10], [16], [19], [22], [28], [40]–[42]. Wolf et al, 2006 [16] conducted the association in CLL, MCL, bladder cancer, prostate cancer and HNSCC.…”

“…For rs6557634, only three studies were found [19], [28], [42] and on combining the results of these studies with our study (total 832 patients/723 control), overall a marginal significant association was found for cancer risk with A vs. G [OR = 1.22 (1.05–1.42), p = 0.011], AA vs. GG [OR = 1.52 (1.06–2.19), p = 0.023] and in dominant model [AA+AG vs. GG: OR = 1.29 (1.05–1.60), p = 0.017, Figure S3 in File S1]. In subgroup analysis these association were found limited to only Caucasians and for GI cancer (Table 6).…”

“…Additionally, rs20576 variant carriers exhibited significantly enhanced colorectal cancer risk dependent on allele dose for female and also with advanced colorectal cancer stages [22]. However, some studies have also reported null association of this SNP with bladder [19], breast [10], [42] and lung cancers [28], [40]. In meta-analysis study, Chen et al also indicated increased risk of all types of cancer with AC and CC variants of rs20576 [51], but we failed to show any association with overall cancer risk and subgroups.…”