Distribution of HLA Tissue Groups in Patients with Gastric Cancer

Bilici, Mehmet; Çayır, Kerim; Pirim, İbrahim; Tekin, Salim Başol; Gündoğdu, Cemal

doi:10.5152/eajm.2010.03

Cited by 4 publications

(12 citation statements)

References 17 publications

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“…HLA-DR, as a T lymphocyte immune-regulatory molecule has been shown to vary during the cancer progression [28]. Saraiva et al, demonstrated that HLA-DR + expression signi cantly declined in cancer subjects and is strongly connected with prognosis [29][30], as reported in 67% of gastric cancer cases and in 80% of poorly differentiated adenocarcinoma [31]. Intriguingly, our study showed that HLA-DR co-expression in CD3, CD4 and CD8 subsets was a signi cant trend towards suppression of drug stimuli.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

Deng

Tang

et al. 2020

Preprint

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Background: T lymphocyte subsets with correlative cytokines, albumin to globulin ratio (AGR) and neutrophil to lymphocyte ratio (NLR), have been linked to inflammatory indicators of immune response and prognosis in various cancer types. The aim of this study was to determine the utility of these biomarkers in predicting the immunological benefits of Ganoderma spore powder in post-operative patients with breast and lung cancer. Methods: We prospectively evaluated 120 consecutive breast and lung cancer patients with or without Ganoderma spore powder. T lymphocyte subsets, as well as relative cytokines were detected and assessed by Pearson correlation analysis. The relationships between AGR and NLR with ganoderma spore powder treatment and prognosis were analyzed using Kaplan–Meier and Cox regression methods.Results: The prevalence of CD3+, CD4+ and CD4+/CD8+, CD3+HLADR-, CD4+HLADR- and CD8+HLADR- cell types was higher in the ganderma spore treated group compared to untreated controls. In addition, the percentage of CD4+CD25+Treg, CD3+HLADR+, CD4+HLADR+ and CD8+HLADR+ cell types was lower in the treated group. IL-2 and IL-12 frequencies were significantly higher during the treatment period which negatively impacted levels of IL-10. Other immunosuppressive factors such as COX2, TGF- 1 and HIF-1A had higher prevalence in non-treated patients. Correlation analysis showed several correlations between the biomarkers, specifically between IL-6 and TGF- 1, CD28 and IL-12R, TGF- 1 and Foxp3, IL-10 and IL-12R with COX2, Foxp3 and CD8, IL-10 and CD28 with IL-12R, COX2 and CD8, IL-12R with COX2, CD3 with CD4 and CD8. A positive relationship was also observed between IL-2 and TGF- 1. Conversely, IL-2 was negatively related to CD3, and HIF-1 negatively related with CD4, CD28 and CD3. Kaplan–Meier analysis suggested that low AGR/high NLR was related to poor progression free survival (PFS, HR=1.572, P=0.038/HR=2.064, P=0.042). A combination of high AGR and low NLR that predicted treatment benefits was also associated with PFS (HR=0.661, P=0.033/HR=1.044, P=0.048).Conclusions: Our findings show that T lymphocyte subsets predominately combined with relevant cytokines and AGR/NLR inflammatory predictors may help to identify patients most likely to benefit from the immunological enhancements from Ganoderma spore powder treatment.

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Section: Discussionmentioning

confidence: 99%

Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

Deng

Tang

et al. 2020

Preprint

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“…26,30 In the included studies, a total of 1656 patients and 16,787 healthy controls were examined. A wide range of heterogeneous study populations were covered with different ethnic groups from four World Health Organization (WHO) regions including Western Pacific Region (WPR) (Japan, Taiwan, South Korea, China), [29][30][31][32][33][34][35][36] European Region (EUR) (Turkey, Spain, Germany, and Sweden), 18,26,27,[37][38][39] Region of the Americas (AMR) (Mexico and Chile), 19,28,40,41 and Eastern Mediterranean Region (EMR) (Iran). 25 The highest number of articles belonged to the Japanese population, with a total of four, [29][30][31][32] followed by Mexico with three.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Fifteen studies analyzed above-mentioned disease among H. pylori infected patients, whereas four studies did not mention H. pylori infection. 25,27,36,38 However, their studied diseases (GAC & GC) are directly associated with H. pylori infection. 3,42 All case and control populations were above 18-yearold and inclusive of both males and females.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…18,27,35 However, HLA-A*02 allele was studied in another three study groups with three different populations (German, Chinese, and Japanese, respectively) without having any significant impact on GC. 26,32,35 Similarly, HLA-Cw*3 was not associated with disease susceptibility in the Turkish and Japanese populations, 27,32 and HLA-Cw*5 was reported as a nonsignificant allele when studied in the Chinese and Japanese populations, independently. 32,35 Li Z et al study analyzed HLA-Cw3 genotype impact on the disease susceptibility and found that CW*03/CW*03 or CW*03/CW*N (N indicates any allele other than *03) containing population has a high risk for GC.…”

Section: Class I Hla Allelementioning

confidence: 99%

“…An overview of the risk of bias assessment report using the RoBANS tool for the eligible studies is depicted in Figure 2. In case of selection bias under selection of participant's domain, three studies were flagged as high risk of bias because of the case and controls were not selected from the comparable populations, [25][26][27] whereas one study was rated as unclear due to the lack of proper description of control population. 28 Confounding variables or confounders are connected to both the presumed cause and the presumed effect of the study and therefore important to report for any study.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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Association of HLA gene polymorphisms with Helicobacter pylori related gastric cancer—a systematic review

Mahmud,

Ahmed,

Rana

et al. 2024

HLA

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The appropriate host cell immune responses for the progression of several diseases, including gastric or stomach cancer (GC), are significantly influenced by HLA polymorphisms. Our objective was to systematically review the evidence linking HLA polymorphisms with the risk of Helicobacter. pylori related GC. We conducted a comprehensive literature search to identify studies published between 2000 and April 2023 on the association of HLA polymorphisms with H. pylori related GC using databases such as Medline through PubMed, Embase, Web of Science (core collection), The Cochrane Library, and Scopus. Two authors independently screened articles, extracted data, and assessed the risk of bias using the Risk of Bias Assessment tool for Non‐randomized Studies. From 7872 retrieved studies, 19 met inclusion criteria, encompassing 1656 cases and 16,787 controls across four World Health Organization regions, with Japan contributing the most studies. We explored HLA‐A/B/C, HLA‐DRB1/DQA1/DQB1, HLA‐G, and MICA alleles. Of 29 significant HLA polymorphisms identified, 18 showed a positive association with GC, whereas 11 were negatively associated. HLA‐DQB1*06 allele was most frequently associated to susceptibility, as reported in four studies, followed by HLA‐DRB1*04 and HLA‐DQA1*01, each reported in two studies. Conversely, HLA‐G*01, HLA‐DQA1*01, HLA‐DQA1*05, and HLA‐DQB1*03 were identified as protective in two studies each. Additionally, five genotypes and six haplotypes were reported as positive, whereas three genotypes and two haplotypes were negative factors for the disease incidence or mortality. Despite heterogeneity in the study population and types of HLA polymorphisms examined, our analysis indicates certain polymorphisms are associated with H. pylori related GC progression and mortality in specific populations.

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Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population

Kocak

Sarıbaş

Demiryas

et al. 2020

Infection, Genetics and Evolution

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Distribution of HLA Tissue Groups in Patients with Gastric Cancer

Cited by 4 publications

References 17 publications

Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

Association of HLA gene polymorphisms with Helicobacter pylori related gastric cancer—a systematic review

Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population

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