A parametric investigation was carried out to estimate the Uranium concentration and other associated water quality parameters for the groundwater in Deoghar district, Jharkhand. Total 150 groundwater samples have been collected from dig wells, hand pumps, tube wells, etc. for the pre and post-monsoon seasons. A Quantalase Uranium analyzer was used to measure the uranium concentration. The distribution of pH, TDS, DO, nitrate, sulfate, uranium along with the radiation has been determined. It was found that the uranium concentration in groundwater varies from 0.10 to 11.30ppb in pre-monsoon and 0.15–6.50ppb in the post-monsoon which is well below the normal tolerance limit (i.e.30 μg/l WHO). This low availability of Uranium has been attributed due to the existence of a lesser number of rocks containing uranium as a source in that area. An attempt has been made to correlate the uranium concentration with the water quality parameters for both seasons. The correlation data reveals that ORP, nitrate, phosphate, calcium, and magnesium show a positive correlation with uranium concentration for both seasons on the other hand TDS, EC, temperature, DO, fluoride, and chloride show negative correlation. The positive correlation implies that uranium may be present in groundwater as a dissolved salt of these parameters. Comparative studies for the parameters have been done for both the seasons and various factors have been discussed for the occurrence of the same. The annual effective dose associated with the ingestion of uranium by the population of the region has been estimated using USPEA equations.