Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20–70 years*

Kerkhof, Marjan; Droste, J. H. J.; Monchy, J. G. R. De; Schouten, Jan P.; Rijcken, B

doi:10.1111/j.1398-9995.1996.tb00021.x

Cited by 59 publications

(53 citation statements)

References 13 publications

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“…Our results corroborate previous observations that showed a positive relationship between active smoking and total serum IgE levels [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. It is possible that persons with any allergic disorder are more likely not to start smoking or to quit smoking if they do smoke and that those without such symptoms are likely to go on smoking (healthy smoker effect).…”

Section: Discussionsupporting

confidence: 82%

“…A number of epidemiological studies have showed that cigarette smoking is associated with elevated concentrations of total serum IgE [3, 4, 5, 6, 7, 8, 9, 10], even after adjustment for age and sex [11, 12, 13, 14, 15]. Also, there have been some studies that investigated the relationship between exposure to environmental tobacco smoke (ETS) and total serum IgE in adults.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Active and Passive Smoking and Total Serum IgE Levels in Japanese Women: Baseline Data from the Osaka Maternal and Child Health Study

Miyake

Miyamoto²,

Ohya³

et al. 2004

Int Arch Allergy Immunol

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Background: Many studies have shown that cigarette smoking is associated with elevated concentrations of total serum IgE. Few studies, however, have examined total IgE in relation to passive smoking exposure, especially in adults. This cross-sectional study investigated the association of active and passive smoking exposure with levels of total serum IgE in Japan. Methods: Study subjects were 981 pregnant women in Osaka. Total IgE levels were measured using UniCAP 1000 and were defined as elevated if they exceeded 170 ml/UI. Age, gestation, parity, family history of asthma, atopic eczema and allergic rhinitis, indoor domestic pets, family income, education and the mite allergen level in house dust were selected as potential confounding factors. Results: Current smoking of at least 15 cigarettes a day and 8.0 or more pack-years of smoking were independently related to an increased prevalence of elevated total serum IgE (adjusted odds ratios 3.40 and 2.51, 95% confidence intervals 2.12–5.47 and 1.55–4.06, respectively), and both cigarette smoking status and pack-years of smoking were significantly positively associated with total serum IgE levels, especially in subjects with a positive familial allergic history. There was no measurable association of exposure to environmental tobacco smoke (ETS) at home or at work with total serum IgE concentrations among those who had never smoked. Conclusions: Our results corroborate a positive relationship between active smoking and total serum IgE levels; however, this study failed to substantiate a positive association of ETS exposure with total IgE. Investigations with more precise and detailed exposure measurements are warranted.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Relationship between Active and Passive Smoking and Total Serum IgE Levels in Japanese Women: Baseline Data from the Osaka Maternal and Child Health Study

Miyake

Miyamoto²,

Ohya³

et al. 2004

Int Arch Allergy Immunol

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“…The decline is similar to studies carried out in the age groups of 20–70 years which found a decline in mite IgE with increasing age [53]. …”

Section: Discussionsupporting

confidence: 73%

“…A higher prevalence of allergies in males, when described by mite IgE [53, 54] or by mite SPT [55, 56,] has been described in several studies in Europe. The absence of a gender-related difference in mite SPT has been observed in other studies conducted in developing countries [8, 30] and the mechanisms behind this discrepancy in the data generated in western populations and those in developing countries have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Clustering of Allergic Outcomes within Families and Households in Areas Endemic for Helminth Infections

Wahyuni

Sartono²,

Supali

et al. 2005

Int Arch Allergy Immunol

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Background: Allergy and helminth infections share key immunological features in terms of Th2 responses. Although in industrialized countries clustering of allergic disorders within families has been frequently reported, such information is lacking from areas where helminth infections are endemic. Methods: A total of 466 subjects from 29 families and 112 households participated in this study. Filarial infection, skin test reactivity and IgE to mite as well as total IgE were measured in all samples. Clustering of the allergy-related outcomes due to genetic and household factors was tested. Results: Genetic factors contributed significantly to the clustering of total IgE and allergen-specific IgE, whereas only household factors contributed to the clustering of SPT positivity. Conclusion: Similar to several studies conducted in western populations, total IgE and allergen-specific IgE are influenced by genetic factors in a population resident in a helminth endemic area. However, clustering of SPT positivity due to genetic factors was not significant in the current study raising the question of whether the presence of helminth infections may override genes that are associated with the expression of tissue reactivity to allergens in the west.

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“…However, the effects of being overweight or obese in patients with chronic kidney diseaseundergoing hemodialysis are paradoxicallyin the opposite direction. This phenomenon has been referred to as ‘reverse epidemiology’ [44]. Among PD patients the amount of glucose absorbed from the dialysis solution makes caloric malnutrition unusual.…”

Section: Discussionmentioning

confidence: 99%

Electronegative LDL and Lipid Abnormalities in Patients Undergoing Hemodialysis and Peritoneal Dialysis

et al. 2008

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Background: Oxidative modification of low-density lipoprotein (LDL) has been demonstrated in patients with end-stage renal disease, where it is associated with oxidative stress and plays a key role in the pathogenesis of atherosclerosis. In this context, the generation of minimally oxidized LDL, also called electronegative LDL [LDL(–)], has been associated with active disease, and is a detectable sign of atherogenic tendencies. The purpose of this study was to evaluate serum LDL(–) levels and anti-LDL(–) IgG autoantibodies in end-stage renal disease patients on dialysis, comparing patients on hemodialysis (HD), peritoneal dialysis (PD) and a control group. In addition, the serum lipid profile, nutritional status, biochemical data and parameters of mineral metabolism were also evaluated. Methods: The serum levels of LDL(–) and anti-LDL(–) IgG autoantibodies were measured in 25 patients undergoing HD and 11 patients undergoing PD at the Centro Integrado de Nefrologia, Rio de Janeiro, Brazil. Ten healthy subjects served as a control group. Serum levels of albumin, total cholesterol, triglycerides and lipoproteins were measured. Calculations of subjects’ body mass index and measurements of waist circumference, triceps skin fold and arm muscle area were performed. Measurements of hematocrit, serum blood urea nitrogen, creatinine, parathyroid hormone, phosphorus and calcium were taken. Results: Levels of LDL(–) were higher in HD patients (575.6 ± 233.1 µg/ml) as compared to PD patients (223.4 ± 117.5 µg/ml, p < 0.05), which in turn were higher than in the control group (54.9 ± 33.3 µg/ml, p < 0.01). The anti-LDL(–) IgG autoantibodies were increased in controls (0.36 ± 0.09 µg/ml) as compared to PD (0.28 ± 0.12 µg/ml, p < 0.001) and HD patients (0.2 ± 0.1 µg/ml, p < 0.001). The mean values of total cholesterol and LDL were considered high in the PD group, whereas the mean triceps skin fold was significantly lower in the HD group. Conclusion: Levels of LDL(–) are higher in renal patients on dialysis than in normal individuals, and are reciprocally related to IgG autoantibodies. LDL(–) may be a useful marker of oxidative stress, and this study suggests that HD patients are more susceptible to cardiovascular risk due to this condition. Moreover, autoantibodies reactive to LDL(–) may have protective effects in chronic kidney disease.

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Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20–70 years*

Cited by 59 publications

References 13 publications

Relationship between Active and Passive Smoking and Total Serum IgE Levels in Japanese Women: Baseline Data from the Osaka Maternal and Child Health Study

Relationship between Active and Passive Smoking and Total Serum IgE Levels in Japanese Women: Baseline Data from the Osaka Maternal and Child Health Study

Clustering of Allergic Outcomes within Families and Households in Areas Endemic for Helminth Infections

Electronegative LDL and Lipid Abnormalities in Patients Undergoing Hemodialysis and Peritoneal Dialysis

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