Distribution of Two Types of Mast Cells in the Nasal Mucosa after Chemosurgical Treatment of Allergic Rhinitis using Trichloroacetic Acid

Abstract

To evaluate the efficacy of chemosurgery using trichloroacetic acid (TeA) for allergic rhinitis, two types of tissue mast cells [tryptase-positive, chymase-negative mast cells (MC T ) and tryptase-positive, chymase-positive mast cells (MC TC )] in the nasal turbinate mucosa were immunohistochemically identified and their distribution was assessed in clinical cases of patients who underwent unilateral TCA treatment. A comparison of the number of MC T and MC TC between the treated and nontreated sides indicates that both types of mast cells are significantly decreased in number in the treated side both in epithelial and lamina propria layers. The results indicate that TCA treatment was effective in suppressing MCT infiltration, regarded as a major cause of antigen-dependent allergy.

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“…TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years. [41][42][43][44][45][46][47][48][49][50][51] The application of 50% or 80% TCA solution modulates nasal epithelial cells-a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge. It was demonstrated to have an indirect positive effect on the lower respiratory tract, influencing the development and modulating the course of allergic asthma.…”

“…The intranasal application of TCA is of particular interest. TCA has been successfully utilized for chemosurgery of allergic rhinitis for over 25 years 41‐51 . The application of 50% or 80% TCA solution modulates nasal epithelial cells—a docking point of airborne allergens (ie, pollens) and the allergen itself, which leads to significant improvement in nasal obstruction, sneezing, and watery nasal discharge.…”