Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

Sheng, Hao; Gu, Lihua; Yang, Pei; Lucas, Molly V.; Gao, Lijuan; Zhang, Hongxing; Zhang, Haisan; Xu, Zhan; Wu, Wei; Li, Ling; Zhang, Zhijun

doi:10.1016/j.nicl.2021.102572

Cited by 6 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Borhani et al (2021) reported that faster working memory retrieval was significantly correlated with increased resting-state delta and theta band powers over the left parietal sites in healthy older adults. A recent simultaneous EEG-functional magnetic resonance imaging (fMRI) study observed that individuals with MCI exhibited chaotic event-related potentials during the word retrieval task while preserving the spatial activity pattern ( Shu et al, 2021 ). However, it remains obscure that whether the resting theta power is linked to the delayed recall memory in the elderly people without dementia.…”

Section: Introductionmentioning

confidence: 99%

Distinct Effects of the Apolipoprotein E ε4 Genotype on Associations Between Delayed Recall Performance and Resting-State Electroencephalography Theta Power in Elderly People Without Dementia

Wang

Sun²,

Zhang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

BackgroundAbnormal electroencephalography (EEG) activity has been demonstrated in mild cognitive impairment (MCI), and theta rhythm might be inversely related to memory. The apolipoprotein E (ApoE) epsilon 4 (ε4) allele, as a genetic vulnerability factor for pathologic and normal age-related cognitive decline, may influence different patterns of cognitive dysfunction. Therefore, the present study primarily aimed to verify the role of resting theta rhythm in delayed recall deficits, and further explore the effects of the ApoE genotype on the associations between the resting theta power and delayed recall performance in the elderly individuals without dementia.MethodsA total of 47 individuals without dementia, including 23 MCI and 24 healthy subjects (HCs), participated in the study. All subjects were administered the Hopkins Verbal Learning Test–Revised (HVLT-R) to measure delayed recall performance. Power spectra based on resting-state EEG data were used to examine brain oscillations. Linear regression was used to examine the relationships between EEG power and delayed recall performance in each subgroup.ResultsThe increased theta power in the bilateral central and temporal areas (Ps = 0.02–0.044, uncorrected) was found in the patients with MCI, and were negatively correlated with delayed recall performance (rs = −0.358 to −0.306, Ps = 0.014–0.036, FDR corrected) in the elderly individuals without dementia. The worse delayed recall performance was associated with higher theta power in the left central and temporal areas, especially in ApoE ε4 non-carriers and not in carriers (rs = −0.404 to −0.369, Ps = 0.02–0.035, uncorrected).ConclusionOur study suggests that theta disturbances might contribute to delayed recall memory decline. The ApoE genotype may have distinct effects on EEG-based neural correlates of episodic memory performance.

show abstract

Section: Introductionmentioning

confidence: 99%

Distinct Effects of the Apolipoprotein E ε4 Genotype on Associations Between Delayed Recall Performance and Resting-State Electroencephalography Theta Power in Elderly People Without Dementia

Wang

Sun²,

Zhang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Alzheimer’s disease (AD), which is characterized by latent and progressive cognitive decline, is the most common etiology for dementia and is recognized as an urgent concern that has significant implications for both individuals and society ( Lane et al, 2018 ). Mild cognitive impairment (MCI), which is considered a transitional state between normal aging and dementia, has a conversion range of 8–15% per year ( Shu et al, 2021 ). In line with recommendations form the National Institute on Aging-Alzheimers’s Association workgroups, we use the term “MCI due to AD” to refer to the symptomatic predementia phase of AD, which suggests that MCI is a critical stage for preventive treatment for dementia ( Albert et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment

Shao

Wang

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objective: To explore the relationship between white matter changes and olfactory ability among patients with mild cognitive impairment (MCI) and to develop a tool to predict the development of Alzheimer’s disease among patients with MCI.Methods: The Montreal Cognitive Assessment (MoCA) was used for cognitive assessments, and the 70% isopropanol test paper was used to evaluate olfactory function. Tract-based spatial statistics, based on the diffusion tensor imaging technology, were used to obtain relevant parameters, and behavioral and imaging results were compared between patients with MCI (n = 36) and healthy older adults (n = 32).Results: The olfactory ability of MCI patients was lower overall, which was positively correlated with the MoCA score. Fractional anisotropy (FA) changes significantly of all parameters. Lower FA regions were mainly located in the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe. The olfactory score was significantly correlated with the FA value of the orbitofrontal gyrus. Fibrous connections in several brain regions, such as the entorhinal cortex, were stronger in patients with MCI.Conclusion: The olfactory ability of MCI patients in our group was positively correlated with the neuropsychological scale results. Impairment in olfactory function was superior to memory deficits for predicting cognitive decline among cognitively intact participants. The fibrous connections in several brain regions, such as the entorhinal cortex, were higher in patients with MCI, which suggested that there may be a compensatory mechanism in the olfactory pathway in MCI patients. The decline in olfactory function may be a significant and useful indicator of neuropathological changes in MCI patients and an effective marker for the development of cognitive decline and dementia.

show abstract

Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task

Rivas-Fernández,

Varela-López,

Zurrón

et al. 2024

Biological Psychology

View full text Add to dashboard Cite

Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

Cited by 6 publications

References 37 publications

Distinct Effects of the Apolipoprotein E ε4 Genotype on Associations Between Delayed Recall Performance and Resting-State Electroencephalography Theta Power in Elderly People Without Dementia

Distinct Effects of the Apolipoprotein E ε4 Genotype on Associations Between Delayed Recall Performance and Resting-State Electroencephalography Theta Power in Elderly People Without Dementia

Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment

Subjective cognitive decline is associated with altered patterns of brain activity and connectivity during performance of an old/new recognition memory task

Contact Info

Product

Resources

About