Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Araya, Jorge E.; Neira, Iván; Silva, Solange da; Mortara, Renato Arruda; Manque, Patrício; Cordero, Esteban; Sagua, H; Loyola, Alberto; Bórquez, Jorge; Morales, Glauco; González, Jorge

doi:10.1590/s0074-02762003000300022

Cited by 42 publications

(45 citation statements)

References 31 publications

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“…A partir do extrato da planta Dracocephalum kotschyi foram obtidos metabólitos potencialmente ativos contra a forma epimastigotas de Trypanosoma cruzi (Saeidnia et al, 2004). Para complementar a relevância dos estudos envolvendo extratos vegetais com atividade tripanocida, pode-se citar também o trabalho realizado com a planta Azorella compacta, através do qual foram obtidos diterpenoides ativos frente à forma amastigota intracelular do T. cruzi (Araya et al, 2003).…”

Section: Resultsunclassified

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Estevam

Silva

Miranda

et al. 2016

Rev. bras. plantas med.

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RESUMO:O objetivo deste estudo foi avaliar o efeito antibacteriano e tripanocida in vitro do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Commelinaceae), conhecida popularmente como veludo branco. Foi avaliada a atividade antibacteriana in vitro frente às bactérias Streptococcus mitis (CIM = 100 µg/mL; CMB = 150 µg/mL), Streptococcus mutans (CIM = 200 µg/mL; CMB = 220 µg/mL), Streptococcus sanguinis (CIM = 400 µg/mL; CMB = 425 µg/mL), Streptococcus sobrinus (CIM = 400 µg/mL; CMB = 420 µg/mL) e Bacteroides fragilis (CIM = 400 µg/mL; CMB = 430 µg/mL) pelo método de diluição em caldo. Os protozoários da família tripanossomatídeo causam doenças tropicais que costumam ser negligenciadas que costumam ser como a tripanossomíase, para a qual estão disponíveis poucos medicamentos. Neste contexto, o extrato hidroalcóolico das raízes de T. sillamontana também foi avaliado frente às formas tripomastigotas da cepa Y de Trypanosoma cruzi, com promissora atividade frente a este protozoário (IC 50 = 2,4 µg/mL). Quando avaliada a atividade citotóxica frente a fibroblastos da linhagem LLCMK 2 , o extrato apresentou moderada citotoxicidade (CC 50 = 480,37 µg/mL). Os resultados ora apresentados para o extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda demonstraram promissoras atividades antibacteriana e tripanocida, sendo uma fonte alternativa de produtos naturais com atividades contra T. cruzi e algumas bactérias do gênero Streptococcus e Bacteroides. Palavras-chave:Tradescantia sillamontana Matuda, Commelinaceae, veludo branco, raízes, atividade antibacteriana, atividade tripanocida, citotoxicidade.ABSTRACT: Evaluation of antibacterial, trypanocidal and cytotoxical activities of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae). The aim of this study was to investigate the in vitro, antibacterial and trypanocidal effect of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Commelinaceae), commonly known as Veludo branco. The in vitro antibacterial activity against the standard bacteria Streptococcus mitis (MIC = 100µg/mL; MBC = 150 µg/ mL), Streptococcus mutans (MIC = 200µg/mL; MBC = 220 µg/mL), Streptococcus sanguinis (MIC = 400µg/mL; MBC = 425 µg/mL), Streptococcus sobrinus (MIC = 400µg/mL; MBC = 420 µg/mL) andBacteroides fragilis (MIC = 400µg/mL; MBC = 430 µg/mL), using microdilution broth methods. Protozoans from the trypanosomatid family cause neglected tropical diseases such as trypanosomiasis, for which few drugs are available. In this context, the hydroalcoholic extract of the Tradescantia sillamontana roots was also investigated with regards to the in vitro effects against the trypomastigote forms of theY strain of Trypanosoma cruzi, showing strong activity against this parasite (IC 50 = 2.4 µg/mL). When performing cytotoxic activity against fibroblasts LLCMK 2 line, the extract showed moderate cytotoxicity (CC 50 = 480.37 mg/mL).

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Section: Resultsunclassified

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Estevam

Silva

Miranda

et al. 2016

Rev. bras. plantas med.

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“…The whole plant is used in indigenous medicine to treat a large variety of ailments, such as bronchitis, asthma and colds and its metabolites have important biological activities. [5][6][7] Another species belonging to this genus is A. trifurcata which grows in humid prairies. Previous phytochemical studies of A. trifurcata reported the isolation of polypolyacetylenic compounds.…”

Section: Introductionmentioning

confidence: 99%

Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase

et al. 2009

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Recebido em 15/7/08; aceito em 4/5/09; publicado na web 6/10/09The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane-and two cycloartane-type triterpenes, together with two mulinane-type diterpenes were isolated from petroleum ether extract of the whole shrub of Azorella trifurcata (Gaertn.) Pers. Their effect on the enzyme acetylcholinesterase was assessed as well. In addition, this is the first report of these triterpenes in the genus Azorella.

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“…There is no satisfactory chemotherapy for the disease in any of its phases. The scarcity of serological control for blood donors in endemic areas and the restricted alternative of chemoprophylaxis using gentian violet, have caused a need to the development of new drugs against this disease (Araya et al, 2003;WHO, 2000).…”

Section: Introductionmentioning

confidence: 99%

Biological activities and chemical composition of crude extracts from Chresta exsucca

Schinor¹,

Salvador²,

Tomaz³

et al. 2006

Rev. Bras. Cienc. Farm.

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Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Cited by 42 publications

References 31 publications

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase

Biological activities and chemical composition of crude extracts from Chresta exsucca

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