Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

Zhang, Xiaoqiang; Fu, Li; Zhao, Zhigang; Liu, Xingli; Tang, Yezhong; Wang, Mingkui

doi:10.1016/j.phytol.2012.07.011

Cited by 20 publications

(9 citation statements)

References 16 publications

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“…Investigation of J. curcas , collected from China, resulted in the isolation of twelve phorbol esters (diterpenoids) including jatrophalactone ( 11 ), curcusecon A–J, 4-epi-curcusecon E, curcusone E, 3-dehydroxy-2-epi-caniojane ( 12 ), curcusone A ( 13 ), curcusone B ( 14 ), curcusone C ( 15 ), curcusone D ( 16 ), jatrogrosidone, 2-epi-jatrogrossidone, and 4 E -jatrogrossidentadion ( 17 ) [ 72 ]. Most of these compounds showed potent cytotoxicity with IC 50 values ranging from 0.084 to 20.6 µM against HL-60, SMMC-7721, A-549, MCF-7, SW480, and HEPG2 cell lines [ 72 , 73 ].…”

Section: Phytochemistry Of Ethiopian Anticancer Plantsmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.

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Section: Phytochemistry Of Ethiopian Anticancer Plantsmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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“…Jatropha and Euphorbia belong to the Crotonoideae and Euphorbioideae subfamilies, respectively, which contain the majority of diterpenoid-producing species within the Euphorbiaceae (Supplemental Figure 6) (Beutler et al, 1989). J. curcas in particular is known to produce a wide variety of diterpenoids, including a number of diterpenoids within roots (Zhang et al, 2012) and phorbol esters within seeds (Haas et al, 2002;He et al, 2011). E. peplus also produces a range of diterpenoids, including the licensed pharmaceutical ingenol mebutate (Hohmann et al, 2000).…”

Section: Clustering Of Diterpenoid Biosynthetic Genes Is Common In Thmentioning

confidence: 99%

Production of Bioactive Diterpenoids in the Euphorbiaceae Depends on Evolutionarily Conserved Gene Clusters

et al. 2014

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The Euphorbiaceae produce a diverse range of diterpenoids, many of which have pharmacological activities. These diterpenoids include ingenol mebutate, which is licensed for the treatment of a precancerous skin condition (actinic keratosis), and phorbol derivatives such as resiniferatoxin and prostratin, which are undergoing investigation for the treatment of severe pain and HIV, respectively. Despite the interest in these diterpenoids, their biosynthesis is poorly understood at present, with the only characterized step being the conversion of geranylgeranyl pyrophosphate into casbene. Here, we report a physical cluster of diterpenoid biosynthetic genes from castor (Ricinus communis), including casbene synthases and cytochrome P450s from the CYP726A subfamily. CYP726A14, CYP726A17, and CYP726A18 were able to catalyze 5-oxidation of casbene, a conserved oxidation step in the biosynthesis of this family of medicinally important diterpenoids. CYP726A16 catalyzed 7,8-epoxidation of 5-keto-casbene and CYP726A15 catalyzed 5-oxidation of neocembrene. Evidence of similar gene clustering was also found in two other Euphorbiaceae, including Euphorbia peplus, the source organism of ingenol mebutate. These results demonstrate conservation of gene clusters at the higher taxonomic level of the plant family and that this phenomenon could prove useful in further elucidating diterpenoid biosynthetic pathways.

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“…Jatropha curcas Linn belonging to the family Euphorbiaceae is a drought-resistant shrub originating in Central and South America but now thrives in many parts of the tropics and subtropics in Africa and Asia [ 97 ]. J. curcas has been used as traditional medicine to cure Buruli ulcer [ 4 ].…”

Section: An Overview Of the Assay Methods Used To Estimate Antimycmentioning

confidence: 99%

Update on Medicinal Plants with Potency onMycobacterium ulcerans

Fokou

Nyarko

Appiah–Opong

et al. 2015

BioMed Research International

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Mycobacterium ulcerans disease has been a serious threat for people living in rural remote areas. Due to poverty or availability of traditional medicine these populations rely on herbal remedies. Currently, data on the anti-Mycobacterium ulcerans activity of plants, so far considered community-based knowledge, have been scientifically confirmed, concomitantly with some medicinal plants used to treat infectious diseases in general. Products derived from plants usually responsible for the biological properties may potentially control Mycobacterium ulcerans disease; numerous studies have aimed to describe the chemical composition of these plant antimicrobials. Thus, the present work provides the first compilation of medicinal plants that demonstrated inhibitory potential on Mycobacterium ulcerans. This work shows that the natural products represent potential alternatives to standard therapies for use as curative medicine for Mycobacterium ulcerans disease.

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Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

Cited by 20 publications

References 16 publications

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Production of Bioactive Diterpenoids in the Euphorbiaceae Depends on Evolutionarily Conserved Gene Clusters

Update on Medicinal Plants with Potency onMycobacterium ulcerans

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