Diterpenylated and prenylated flavonoids from Macaranga denticulata

Phytochemistry and pharmacology of the genus Macaranga: A review

“…This result was comparable to the standard antioxidant [2,6-di-(tertbutyl)-4-methylphenol, BHT] which have an IC 50 value of 0.031 ± 0.001 mM. Scopoletin (157) also showed significant antioxidant property with an IC 50 value of 0.342 ± 0.026 mM (Sutthivaiyakit et al, 2002).…”

“…The pharmacological review of the genus indicated many flavonoids and stilbenes to be isolated from the leaves and exhibited strong, moderate to weak anticancer properties (Kaaden et al, 2001). These two classes of compounds also showed significant antioxidant activities (Sutthivaiyakit et al, 2002). Other compounds indicated anti-inflammatory and antimicrobial properties (Schutz et al, 1995;Ngoumfo et al, 2008).…”

“…These antioxidants are thought to prevent chronic complications in part through their interactions with reactive species and ability to scavenge free radicals (Seifried et al, 2007). Investigation for antioxidant compounds from M. denticulata lead to the isolation of phenolic compounds (3 and 157) which indicated to have significant antioxidant properties (Sutthivaiyakit et al, 2002). These compounds were evaluated for their antioxidant properties using 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable radical.…”

“…A phytochemical review of literatures indicates the genus Macaranga to be a rich source of the isoprenylated, geranylated and farnesylated flavonoids (Schutz et al, 1995;Jang et al, 2002;Phormmart et al, 2005;Kawakami et al, 2008;Thanh et al, 2012) and stilbenes (Beutler et al, 1998;Yoder et al, 2007;Thanh et al, 2012). Furthermore, more classes of secondary metabolites like terpenes (Salah et al, 2003;Jang et al, 2004;Phormmart et al, 2005;Kawakami et al, 2008), tannins (Lin et al, 1990;Gunawan-Puteri and Kawabata, 2010;Ngoumfo et al, 2008), coumarins (Sutthivaiyakit et al, 2002;Darmawan et al, 2012) and other types of compounds (Ramaiah et al, 1979;Ngoumfo et al, 2008;Matsunami et al, 2009;Zakaria et al, 2010) are known to be isolated from different species of the genus Macaranga. Flavonoids and stilbenes are regarded as the major constituents and are most likely responsible for most of the activities found in the plants of this genus.…”

“…An increasing number of phytochemical studies are being carried out on plants belonging to the genus Macaranga due to their various traditional uses. Thus, the isolated natural products from this genus have been reported to display interesting biological activities including antitumor (Kaaden et al, 2001;Yoder et al, 2007;Zakaria et al, 2012), antioxidant (Sutthivaiyakit et al, 2002;Phormmart et al, 2005;Matsunami et al, 2009), antimicrobial (Salah et al, 2003;Lim et al, 2009) and anti-inflammatory (Jang, et al, 2002). This is a resourceful area of research as many species of Macaranga are used in traditional medicine as well as exhibits various pharmacological properties while their chemistry indicates varied chemical structures.…”