Dithiocarbamate salts: biological activity, preparation, and utility in organic synthesis

Aly, Ashraf A.; Brown, Alan B.; Bedair, Tarek M.; Ishak, Esam A.

doi:10.1080/17415993.2012.718349

Cited by 29 publications

(16 citation statements)

References 43 publications

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“…Several synthetic procedures have been developed involving one-pot condensation of amines, carbon disulfide and electrophiles such as alkyl halides, epoxides, carbonyl compounds and α,β-unsaturated compounds [ 40 ]. They have been prepared from both the primary and secondary amine [ 32 , 41 , 42 ] as shown in Scheme 1 . The respective amines react with carbon disulfide in the a strong base like potassium/sodium hydroxide or ammonium hydroxide to form the corresponding dithiocarbamate salts of sodium ion (K + /Na + ) or ammonium ion (NH 4 + ).…”

Section: Chemistry Of Organotin(iv) Dithiocarbamatementioning

confidence: 99%

Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

2018

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Significant attention has been given to organotin(IV) dithiocabamate compounds in recent times. This is due to their ability to stabilize specific stereochemistry in their complexes, and their diverse application in agriculture, biology, catalysis and as single source precursors for tin sulfide nanoparticles. These complexes have good coordination chemistry, stability and diverse molecular structures which, thus, prompt their wide range of biological activities. Their unique stereo-electronic properties underline their relevance in the area of medicinal chemistry. Organotin(IV) dithiocabamate compounds owe their functionalities and usefulness to the individual properties of the organotin(IV) and the dithiocarbamate moieties present within the molecule. These individual properties create a synergy of action in the hybrid complex, prompting an enhanced biological activity. In this review, we discuss the chemistry of organotin(IV) dithiocarbamate complexes that accounts for their relevance in biology and medicine.

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Section: Chemistry Of Organotin(iv) Dithiocarbamatementioning

confidence: 99%

Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

2018

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“…Anti-microbial activity [45] 3-Methyl-2-furoic acid Anti-fungal and anti-tumor activity [46] 2,4-Octadienoic acid, 7-hydroxy-6-methyl Analgesic and anti-inflammatory activity [47] Diethyl mercaptal of d-mannose Antibacterial and anti-fungal activity [48] dl-Allo-cystathionine Analgesic, anti-inflammatory, antifungal, antibacterial activity [49] Phloroglucinol Antioxidant, antineoplastic, anti-inflammatory, antimicrobial, antifungal activity [50,51] Acetoacetic acid, 1,3-dithio-, S-ethyl ester Analgesic, antipyretic, antimalarial and antibiotic effect [52,53] β-D-Glucopyranose, 1,6-anhydro-Anti-bacterial and antioxidant effect [54,55] D-Allose Antioxidant, antibacterial and antiviral activity [56,57] Germacrene D Neurological activity, cytotoxicity and antimicrobial activity [58,59] Cis-muurola-3,5-diene Antimicrobial activity [60] β-copaene Cytotoxic and antioxidant effect [61,62] Decanal Antioxidant [63] Dodecanoic acid, 3-hydroxy-Antibacterial, antitumor and antioxidant effect [64] Butanoic acid, octyl ester Effect on CNS, antioxidant, analgesic and anti-inflammatory activity [65,66] Quinic acid Antibacterial, antiviaral, antioxidant and hepatoprotective activity [67][68][69] 1-Heptanol, 2,4-dimethyl-, (R,R)-(+)-Antifungal activity [70] d-Mannitol, 1-decylsulfonyl-Anti-diabetic, anti-microbial activity [71,72] d-Mannitol, 1-thiohexyl-1-deoxy-Anti-microbial activity [73] 4-Diazodamantanone Antimicrobial, anti-inflammatory and antiacetylcholinesterase activities [74,75] 3-Nonyn-2-ol Anti-inflammatory, anti-septic, anti-tumor activity [76,77] Chlorozotocin Anti-tumor, reduction in bone marrow toxicity…”

Section: Compound Name Biological Activity References 124 Benzenetriolmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

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Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

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“…The better of the two approaches is replacement because it gives dithiocarbamates compounds of high purity [10]. Recently, Aly et al reported the synthesis of dithiocarbamate at room temperature against the usual cold less than four degrees Celsius temperature [13]:RNH2l/aq+CS2l+BOHaq⟶RHNCS2Bl/s+H2Ol B:NH4+, Na,or KR2NHl/aq+CS2l+BOHaq⟶R2NCS2Bl/s+H2Ol…”

Section: Introductionmentioning

confidence: 99%

Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications

Odularu

Ajibade

2019

Bioinorganic Chemistry and Applications

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Progresses made in previous researches on syntheses of dithiocarbamates led to increase in further researches. This paper reviews concisely the challenges experienced during the synthesis of dithiocarbamate and mechanisms to overcome them in order to obtain accurate results. Aspects of its precursor’s uses to synthesize adducts, nanoparticles, and nanocomposites are reported. Some common characterization techniques used for the synthesized products were assessed. Biological applications are also reported.

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Dithiocarbamate salts: biological activity, preparation, and utility in organic synthesis

Cited by 29 publications

References 43 publications

Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

Organotin(IV) Dithiocarbamate Complexes: Chemistry and Biological Activity

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications

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