Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug

Savian, Ana L.; Rodrigues, Daiane; Wéber, Júlia; Ribeiro, Roseane Fagundes; Motta, Mariana Heldt; Schaffazick, Scheila Rezende; Adams, Andréa Inês Horn; Andrade, Diego Fontana de; Beck, Ruy Carlos Ruver; Silva, Cristiane B. da

doi:10.1016/j.msec.2014.10.011

Cited by 52 publications

(29 citation statements)

References 41 publications

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“…There was a decrease in the skin permeability coefficient of the drug by nanoencapsulation, independently of the dosage form. Lag time was increased two times by nanoencapsulation, meaning that the drug is retained for a longer time on the skin surface (Savian et al, ).…”

Section: Nanotherapeutics For Psoriasis: Nanocarriers Nanodrugs and mentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

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Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale (“skin nanobiology”), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies (“nanodiagnosis”), and (c) treatment through innovative therapeutic agents, including phototherapy (“photonanotherapy”/“photonanodermatology”) and systemic/topical drug administration (“nanotherapy”) at the nanoscale, and drug delivery—such as transdermal or dermal drug delivery (TDDD/DDD)—enhanced and improved by nanostructures and nanodrugs (“nanodrug delivery”). Nanodermatology, as a super‐specialized branch of dermatology, is a quite recent specialty: the “Nanodermatology Society” founded by the eminent dermatologist Dr. Adnan Nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy‐makers and regulators, as well as students and medical residents. Psoriasis has a prevalence of 2–3% worldwide and imposes a severe clinical and societal burden. Nanodermatology‐based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health‐care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

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Section: Nanotherapeutics For Psoriasis: Nanocarriers Nanodrugs and mentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

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“…The polymer wall prevents direct contact of the drug with the tissue, which is dissolved in the oil core, helping in preventing immediate release of the drug 56,57 causing a lower percentage breakdown than that with NS. Recently, P80-coated PCL-nanocapsules were shown to protect dithranbol, 58 indole-3-carbinol, 59 Coenzyme Q10, 60 quinine, 26 and betamethasone dipropionate. 45 Furthermore, clotrimazole, acetazolamide, and quinine have been reported to demonstrate protection conferred by EUD.…”

Section: Technological Evaluation Of Quinine-loaded Nanocapsulesmentioning

confidence: 99%

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Michels¹,

Maciel²,

Nakama³

et al. 2019

IJN

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Introduction: The surface charge of nanoparticles, such as nanospheres (NS) and nanocapsules (NC), has been studied with the purpose of improving the in vivo performance of drugs. The aim of this study was to develop, characterize, and evaluate the in vitro antimalarial efficacy of NCP80 and NSP80 (polysorbate coated) or NCEUD and NSEUD (prepared with Eudragit RS 100) loading quinine (QN). Methods: Formulations were prepared by the nanoprecipitation method, followed by wide physicochemical characterization. Antimalarial activity in Plasmodium berghei-infected mice and populational pharmacokinetics (PopPK) in rats were evaluated. Results: The formulations showed a nanometric range (between 138 ± 3.8 to 201 ± 23.0 nm), zeta potential (mV) of −33.1 ± 0.7 (NCP80), −30.5 ± 1 (UNCP80), −25.5 ± 1 (NSP80), −20 ± 0.3 (UNSP80), 4.61 ± 1 (NCEUD), 14.1 ± 0.9 (UNCEUD), 2.86 ± 0.3 (NSEUD) and 2.84 ± 0.6 (UNSEUD), content close to 100%, and good QN protection against UVA light. There was a twofold increase in the penetration of QN into infected erythrocytes with NC compared to that with NS. There was a significant increase in t 1/2 for all NC evaluated compared to that of Free-QN, due to changes in Vdss. PopPK analysis showed that NCP80 acted as a covariate to Q (intercompartmental clearance) and V2 (volume of distribution in the peripheral compartment). For NCEUD, V1 and Q were modified after QN nanoencapsulation. Regarding in vivo efficacy, NCEUD increased the survival of mice unlike Free-QN. Conclusion: Cationic nanocapsules modified the pharmacology of QN, presenting a potential alternative for malaria treatment.

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“…The free PS content (FC) was determined in the ultrafiltrate after separation of the nanocapsules by ultrafiltration/centrifugation (Amicon® Ultra 0.5 mL, MW 10000, Millipore, Carrigtwohill, Ireland) at 5460 rpm for 10 min (Savian et al, 2015). The ZnPc in the supernatant was measured using a calibration curve through fluorescence.…”

Section: Determination Of Encapsulation Efficiency(ee)mentioning

confidence: 99%

Evaluation of photodynamic activity, photostability and in vitro drug release of zinc phthalocyanine-loaded nanocapsules

Souza

Ziembowicz

Müller

et al. 2016

European Journal of Pharmaceutical Sciences

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Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug

Cited by 52 publications

References 41 publications

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Evaluation of photodynamic activity, photostability and in vitro drug release of zinc phthalocyanine-loaded nanocapsules

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