Diurnal Variation in the Plasma Iron Level of Man.

Hamilton, L. D.; Gubler, C. J.; Cartwright, G. E.; Wintrobe, M. M.

doi:10.3181/00379727-75-18102

Cited by 140 publications

(36 citation statements)

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“…A definite diurnal variation of the same magnitude as that found by Hamilton et al (1950) is seen in all groups with the exception of the female donor group.…”

Section: Methodssupporting

confidence: 55%

“…They also found a slightly lower mean value during the menopause than immediately before or after. Furthermore, Hamilton et al (1950) were able to show in experiments on rats and dogs that the serum iron level is related to adrenocortical activity. In the light of these findings the low morning value of female donors and the resulting virtual absence of diurnal variation in this group could possibly be attributed to endocrine disturbances in the particular age group due to 1;he menopause.…”

Section: Methodsmentioning

confidence: 88%

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Studies on Intermediary Iron Metabolism

Káldor

1953

Aust J Exp Biol Med

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“…A definite diurnal variation of the same magnitude as that found by Hamilton et al (1950) is seen in all groups with the exception of the female donor group.…”

Section: Methodssupporting

confidence: 55%

Section: Methodsmentioning

confidence: 88%

Studies on Intermediary Iron Metabolism

Káldor

1953

Aust J Exp Biol Med

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“…Plasma iron was determined by the method of Hamilton et d. (15). Heroin was isolated by the method of Fischer (16) and recrystailized and purified in the manner described by Shemin, London, and Rittenberg (17).…”

Section: Methodsmentioning

confidence: 99%

The Kinetics of Iron Metabolism in Normal Growing Swine

Jensen

Bush

Ashenbrucker

et al. 1956

The Journal of Experimental Medicine

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The availability of radioactive iron (Fe 6~) of high specific activity and the development of the scintillation counter enabled Huff et al. (1) to devise a technique for determining the turnover rates of iron through plasma and red cells.This method involves the intravenous injection of a tracer dose of Fe s9 containing a quantity of carrier iron sufficiently small that the plasma iron concentration will not be elevated measurably. The Fe s9 radioactivity disappears from the plasma according to the equation of a first order reaction and the time at which half of the injected dose has disappeared from the plasma (T~) is determined by plotting the counts of serial plasma samples on semilogarithmic paper. The plasma iron turnover rate (PITR) in milligrams per day may be calculated from the formula: 0.693 X PV X PI X 24 --PITR r 1/2 in which PV is the plasma volume in milliliters, PI is the plasma iron concentration in milligrams per milliliter, 24 is the number of hours per day.On subsequent days the red cells are assayed for Fe 59 activity until a constant fraction of injected radioactivity is present in the erythrocytes. The red cell iron turnover rate (RBC ITR) in milligrams per day is calculated from the formula:in which PITR is the plasma iron turnover rate in milligrams per day, FeS, ' is the maximum fraction of injected Fe s9 incorporated into the erythrocytes.The total red cell iron (RBC I) in rag. may then be determined from the formula:TBV 100 X Hb X 3.4 = KBCI

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“…The methods employed have been described in other communications; for the measurement of red blood cell and plasma copper (10); that for the direct-reacting copper fraction of plasma (11); for plasma iron (12); and for total iron-binding capacity of the plasma (13). Total serum protein, albumin and globulin were determined by the biuret method (14) with the modification of Weichselbaum (15).…”

Section: Methodsmentioning

confidence: 99%

Studies on Copper Metabolism. XI. Copper and Iron Metabolism in the Nephrotic Syndrome 1

Cartwright¹,

Gubler²,

Wintrobe³

1954

J. Clin. Invest.

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124

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The metabolism of copper and iron in the nephrotic syndrome has received little attention. In view of the fact that copper in the plasma is bound almost exclusively to an a2-globulin (ceruloplasmin) with a molecular weight of approximately 151,000 (1, 2) while iron is bound to a #l,-globulin (transferrin) with a molecular weight of about 90,000 (3), it would seem not unlikely that these two metal-binding proteins might be excreted in large quantities in the urine of patients with pronounced proteinuria. If this loss were great and extended over a prolonged period, it is conceivable that depletion of the body stores of these two elements might occur or the capacity of the body to synthesize these two proteins might be exceeded, with the consequence that the plasma level of ceruloplasmin and transferrin would be reduced.In the course of investigations in this laboratory concerning the anemia associated with infection (4), a patient was studied who, while afflicted with chronic osteomyelitis, developed the nephrotic syndrome. In association with the severe hypoproteinemia and proteinuria, the plasma copper level decreased from 246 ug. per 100 ml., the high levels usually found with infection, to 40 JUg. per 100 ml. in'spite of the continued presence of osteomyelitis. More recently (5) we observed hypocupremia in two of three children with the nephrotic syndrome. Munch-Petersen (6) has reported that the urinary excretion of copper is increased in patients with proteinuria and that the amount of copper excreted is greatest in those with the highest concentration of protein in the urine. Although he did not record the plasma copper values he stated that there was no correlation between the plasma copper concentration and the amount of copper in the urine.

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Diurnal Variation in the Plasma Iron Level of Man.

Cited by 140 publications

References 0 publications

Studies on Intermediary Iron Metabolism

Studies on Intermediary Iron Metabolism

The Kinetics of Iron Metabolism in Normal Growing Swine

Studies on Copper Metabolism. XI. Copper and Iron Metabolism in the Nephrotic Syndrome 1

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