Diurnal Variations in Immunity

Zhao, Yue; Chen, Yi‐Ping Phoebe

doi:10.1002/9780470015902.a0028361

Cited by 1 publication

(1 citation statement)

References 55 publications

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“… 8 These immunity-mediators oscillate to synchronize with the rest–activity phase of species. 81 Consequently, numerous studies show that mice are highly sensitive and subject to greatly reduced survival when exposed to various pathogens at the beginning of the physical activity phase, that is, early evening. 82–84 Therefore, circadian variation of postradiotherapy toxicities, including mucositis, diarrhea, lymphedema, erythema, and fibrosis, could be related to the cyclic change in immune mediators.…”

Section: Chronobiological Mechanismsmentioning

confidence: 99%

Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity

Ali

Hong

Liu

et al. 2022

Cancer Biology & Therapy

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A large number of studies have reported that tumor cells are often out of sync with the surrounding healthy tissue. Exploiting this misalignment may be a way to obtain a substantial gain in the therapeutic window. Specifically, based on reports to date, we will assess whether radiotherapy outcomes differ depending on the administration time. Collectively, 24 studies met the inclusion criteria, out of which 12 at least reported that radiation therapy is less toxic when administered at a particular time, probably because there is less collateral damage to healthy cells. However, discrepancies exist across studies and urge further investigation. Mechanistic studies elucidating the relationship between radiotherapy, circadian rhythms, and cell cycle, combined with either our “digital” or “biological” chronodata, would help oncologists successfully chronotype individual patients and strategize treatment plans accordingly.

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Section: Chronobiological Mechanismsmentioning

confidence: 99%