Divergent KSHV/HHV-8 subtype D strains in New Caledonia and Solomon Islands, Melanesia

Cassar, Olivier; Charavay, Françoise; Bassot, Sylviane; Plancoulaine, Sabine; Grangeon, Jean-Paul; Laumond-Barny, Sylvie; Martin, Paul; Chanteau, Suzanne; Gessain, Antoine

doi:10.1016/j.jcv.2011.12.016

Cited by 20 publications

(11 citation statements)

References 15 publications

(14 reference statements)

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“…the genotypes of HHv-8 in three patients positive for three OrFs were divergent and were K1 gene subtypes C3, D1, and e. they were somewhat different from those reported in Ks patients in asia [26,27], and in that subtype, e was not reported previously. this was the first report of subtype e HHv-8 in asia.…”

Section: Discussioncontrasting

confidence: 76%

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

Lai

Tsao

et al. 2014

Med Microbiol Immunol

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Human herpesvirus type 8 (HHV-8) DNA is consistently found in all types of Kaposi's sarcoma, which is prevalent in immunocompromised patients. Patients with advanced lung carcinoma often showed immunologic abnormalities, and prevalence of HHV-8 infection is unclear. In this study, blood samples from 109 lung carcinoma patients and 109 age- and sex-matched healthy controls were analyzed for lymphocyte and monocyte counts, and for antibody, DNA, and genotype of HHV-8. Lung carcinoma patients had significantly lower lymphocyte and higher monocyte counts than healthy controls (p < 0.0001, both). HHV-8 seropositivity was more prevalent in lung carcinoma patients (41.3%), particularly in male patients (50.8%), than in controls (24.8%) (p = 0.01 and 0.002, respectively). The seropositivity was also significantly higher in male (50.8%) than female patients (27.3%, p = 0.01). Titers of HHV-8 antibody in patients also significantly exceeded those in controls (p = 0.004). Under a higher threshold (antibody titer ≥1:160) which is equivalent to that of enzyme-linked immunosorbent assay, lung carcinoma patients still had higher HHV-8 seropositivity than controls (p = 0.006). Three patients with stage IV lung carcinoma were positive for HHV-8 DNA with K1 gene subtype C3, D1, and E, respectively; they had much lower lymphocyte counts (658 ± 132 µL) than patients positive for HHV-8 antibodies only (1,449 ± 873 µL). The study indicates that lung carcinoma patients, particularly males, have a high seroprevalence of HHV-8. HHV-8 DNA detected in the patients with advanced lung carcinoma may be a result of virus reactivation in the immunocompromised status.

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Section: Discussioncontrasting

confidence: 76%

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

Lai

Tsao

et al. 2014

Med Microbiol Immunol

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“…HTLV‐1 infection is endemic in sub‐Saharan Africa, the Caribbean, parts of South America, and southern Japan, whereas HTLV‐2 infection is endemic among Pygmies in Africa and Amerindians in North, Central, and South America . It has been reported that HTLV has a high prevalence the southeastern coastal areas of China, predominantly HTLV‐1 .…”

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confidence: 99%

The prevalence of human T‐cell leukemia virus in blood donors in China

Huang

et al. 2019

Transfusion

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BACKGROUND China has not yet incorporated routine human T‐lymphotropic virus (HTLV)‐1/2 blood donor screening, even though HTLV has been reported in the southeastern coastal region. This study was conducted to investigate the prevalence of HTLV in five major regions across of China. METHODS From January 2016 to December 2017, blood samples were collected in 20 blood centers located in different regions of China. These samples were screened for HTLV‐1/2 antibodies using enzyme‐linked immunosorbent assay (ELISA). If the test samples were reactive, the samples were confirmed with a western blot (WB) assay. If the results of WB were indeterminate, the donor was interviewed after a minimum lapse of 8 weeks. All follow‐up samples from donors were tested for anti–HTLV‐1/2 with ELISA and WB. RESULTS There were 875,453 donor samples tested for anti–HTLV‐1/2 by ELISA. In all, 365 samples tested negative, 22 samples tested positive by WB, and 14 samples with HTLV status undetermined due to being lost to follow‐up. The prevalences were 11.09, 5.96, 3.16, 2.88 and 0.98 per 100,000 in Xiamen, Changsha, Beijing, Shenzhen, and Nanjing blood center, respectively. The prevalences were 0 per 100,000 for all 15 other blood centers. There was significant differences in the prevalence of HTLV in different regions of China (p = 0.0011). CONCLUSION In China, HTLV‐1 confirmed positive donors are mainly from southeastern coastal areas. It may be necessary to conduct HTLV screening in these areas to reduce the risk of transfusion‐transmitted HTLV.

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“…Thus, we have frequent access to healthy individuals living in villages of the western part of central Africa (14,15) and South America (16,17) and in patients from hospitals in Oceania (18) and Europe. In order to search for specific geographically related MCPyV genotypes, we tested many individuals originating from the five continents for MCPyV.…”

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confidence: 99%

Molecular Epidemiology of Merkel Cell Polyomavirus: Evidence for Geographically Related Variant Genotypes

et al. 2014

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Divergent KSHV/HHV-8 subtype D strains in New Caledonia and Solomon Islands, Melanesia

Cited by 20 publications

References 15 publications

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

The prevalence of human T‐cell leukemia virus in blood donors in China

Molecular Epidemiology of Merkel Cell Polyomavirus: Evidence for Geographically Related Variant Genotypes

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