Divergent synthesis of two types of indolizines from pyridine-2-acetonitrile, (hetero)arylglyoxal, and TMSCN

Abstract

Described herein is divergent synthesis of two types of indolizines via construction of pyrrole moiety from pyridine-2-acetonitriles, arylglyoxals, and TMSCN. While one-pot three-component coupling provided 2-aryl-3-aminoindolizines via unusual fragmentation process,...

Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes

“…Many of its potential applications are yet to be fully explored, and the synthesis of new indolizine derivatives remains a challenging task. The growing interest in this compound and the promising results obtained so far suggest that indolizine will continue to be a significant focus of research in the coming years [26][27][28]. derivatives remains a challenging task.…”

“…derivatives remains a challenging task. The growing interest in this compound and the promising results obtained so far suggest that indolizine will continue to be a significant focus of research in the coming years [26][27][28].…”