Diverse positional 14C labeling-assisted metabolic analysis of pesticides in rats: The case of vanisulfane, a novel vanillin-derived pesticide

Shao, Siyao; Zheng, Rencheng; Cheng, Xi; Zhang, Sufen; Yu, Zhiyang; Pang, Xingyan; Li, Jiaoyang; Wang, Haiyan; Ye, Qingfu

doi:10.1016/j.scitotenv.2022.153920

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…Acid metabolite M2 can be formed either from heterocyclic M4 or by the further oxidation of aldehyde M3. Similarly, in rats, oxidation of vanisulfane predominated during the whole exposure time . The metabolite M1 was derived from the demethylation of M2.…”

Section: Resultsmentioning

confidence: 70%

“…Similarly, in rats, oxidation of vanisulfane predominated during the whole exposure time. 27 The metabolite M1 was derived from the demethylation of M2. This methyl reduction has also been observed as an important product in the degradation of various pesticides in soils.…”

Section: Uptake and Translocation Of Vanisulfane And Its Metabolites ...mentioning

confidence: 75%

“…Metabolite analysis was conducted by an Agilent 1260 high-performance liquid chromatography (HPLC) instrument configured with an Agilent 6530 quadrupole time-of-flight mass spectrometry (QTOF-MS) instrument (Santa Clara, CA, USA) based on a previous study. 27 A C 18 column (250 × 4.6 mm, 5 μm; Dikma, USA) was used to separate the target analytes. The mobile phase was acetonitrile/0.1% acetic acid and water/0.1% acetic acid at a flow rate of 1 mL min −1 (the detailed mobile phase program is shown in Table S1).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Insights into the Fate of the Novel Pesticide Vanisulfane from Animal Manure in Plant–Soil Systems: Assisted by Carbon-14 Labeling

Shao

Zhang

et al. 2023

J. Agric. Food Chem.

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Pesticide use can result in plant residues, which can be ingested by livestock consuming plant-derived feed and appear in manure. When this manure is applied as a fertilizer, pesticides can contaminate plant−soil systems. Few studies have focused on pesticide infiltration from applying pesticide-contaminated manure to land. In this study, the fate of pesticide vanisulfane from chicken manure was studied in radish−soil and cabbage−soil systems assisted by carbon-14 labeling. Vanisulfane and its metabolites mostly appeared as bound residues (BRs) after introduction, and BR release was found at 35 d. Notably, manure contaminated with vanisulfane and its metabolites exhibited higher plant accumulation and phytotoxicity than manure contaminated with only the parent. Four metabolites were identified, and germination toxicity assays illustrated that a metabolite with an aldehyde structure induced phytotoxicity. This study provides valuable information on pesticide contamination from manure and emphasizes the importance of considering pesticide metabolites when assessing environmental risks.

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Section: Resultsmentioning

confidence: 70%

Section: Uptake and Translocation Of Vanisulfane And Its Metabolites ...mentioning

confidence: 75%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations