Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry

Abstract

Isoquinoline-enrooted organic small-molecules represent a challenging molecular target in the organic synthesis arsenal attributed of its structural diversity and therapeutic importance. Into the bargain, isoquinolines are significant structural frameworks in...

One-pot multistep synthesis of 1-fluoroalkylisoquinolines and fused fluoroalkylpyridines from N-fluoroalkyl-1,2,3-triazoles

“…1). 1–4 Numerous synthetic approaches exist leading to these benzopyridines, such as multistep sequences of reactions including the well-known Bischler–Napieralski, 5 Pomeranz–Fritsch 6 and Pictet–Spengler 7 reactions, as well as processes involving transition metal catalysis. 8…”

“…1). [1][2][3][4] Numerous synthetic approaches exist leading to these benzopyridines, such as multistep sequences of reactions including the well-known Bischler-Napieralski, 5 Pomeranz-Fritsch 6 and Pictet-Spengler 7 reactions, as well as processes involving transition metal catalysis. 8 The introduction of fluorine atoms or fluoroalkyl groups into a lead molecule is a widely used strategy to enhance the pharmacologically relevant properties 9 and several 1-trifluoromethylisoquinolines exploit this trend (Fig.…”