Diversity in Phytochemical Composition and Medicinal Value of <i>Murraya paniculata</i>

Rehman, Rafia; Anila, Anila; Muzaffar, Rabeea; Arshad, Fatimah Mohamed; Hussain, Riaz; Altaf, Ataf Ali

doi:10.1002/cbdv.202200396

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Results of our previous study revealed that activation of Sirt1 increases the expression of FOXO3a (22). TMF is a main bioactive component derived from M. exotica, which exerts multiple pharmacological activities, including anti-inflammatory, antioxidant, analgesic, anti-diabetes and antinociception properties (61,62). TMF may exhibit potential as an activator of Sirt1, enhancing the expression of FOXO3a and mediating cholesterol metabolism in OA chondrocytes (22).…”

Section: Discussionmentioning

confidence: 99%

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

Huang,

Ren,

Jiao

et al. 2024

Exp Ther Med

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Osteoarthritis (OA) is a disease of the joints, characterized by chronic inflammation, cartilage destruction and extracellular matrix (ECM) remodeling. Aberrant chondrocyte hypertrophy promotes cartilage destruction and OA development. Collagen X, the biomarker of chondrocyte hypertrophy, is upregulated by runt-related transcription factor 2 (Runx2), which is mediated by the bone morphogenetic protein 4 (BMP4)/Smad1 signaling pathway. BMP binding endothelial regulator (BMPER), a secreted glycoprotein, acts as an agonist of BMP4. 5,7,3',4'-tetramethoxyflavone (TMF) is a natural flavonoid derived from Murraya exotica L. Results of our previous study demonstrated that TMF exhibits chondroprotective effects against OA development through the activation of Forkhead box protein O3a (FOXO3a) expression. However, whether TMF suppresses chondrocyte hypertrophy through activation of FOXO3a expression and inhibition of BMPER/BMP4/ Smad1 signaling remains unknown. Results of the present study revealed that TMF inhibited collagen X and Runx2 expression, inhibited BMPER/BMP4/Smad1 signaling, and activated FOXO3a expression; thus, protecting against chondrocyte hypertrophy and OA development. However, BMPER overexpression and FOXO3a knockdown impacted the protective effects of TMF. Thus, TMF inhibited chondrocyte hypertrophy in OA cartilage through mediating the FOXO3a/BMPER signaling pathway.

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Section: Discussionmentioning

confidence: 99%

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

Huang,

Ren,

Jiao

et al. 2024

Exp Ther Med

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“…All reagents and controls used for GLC analysis were obtained from Sigma (Sigma Aldrich GmbH, Sternheim, Germany) (Farag et al 2022). Literature survey of the chemical composition of Murraya species was compared with our profiles (Rao et al 2011;Lv et al 2013;Chowdhury et al 2008;Rehman et al 2023).…”

Section: Volatiles Identificationmentioning

confidence: 99%

Anticholinesterases activity of Murraya koenigii (L.) Spreng. and Murraya paniculata (L.) Jacq. essential oils with GC/MS analysis and molecular docking

El-Shiekh

Kassem

Khaleel

et al. 2023

Natural Product Research

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GC/MS analysis of Murraya koenigii (L.) Spreng. and Murraya paniculata (L.) Jacq. leaves revealed the identification of 73 components, with an evident greater contribution of monoterpenes hydrocarbons to their total volatiles. α-Pinene (37.5%) and β-caryophyllene (27.4%) were the most abundant compounds in M. koenigii leaves and β-phellandrene (40.7%) in M. paniculata leaves, using headspace. β-Phellandrene (33.7%) was the major constituent by M. koenigii leaves where germacrene D (23.8%), and δ-elemene (22.0%) were predominant in M. paniculata leaves, using steam distillation. M. koenigii leaves oil showed quite remarkable cholinesterase inhibitory activity, where oil of M. paniculata leaves showed strong inhibitory activity against AChE (IC50=13.2 ± 0.9 µg/mL) and BChE (IC50=5.1 ± 0.3 µg/mL). Germacrene D, α-zingiberene, and δ-elemene showed higher affinity to BChE than AChE as revealed from docking scores (S = -5.65 to -6.03 Kcal/mol) for BChE and (S = -5.56 to -6.25 Kcal/mol) for AChE.

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“…8 Murraya paniculata, a medicinal plant, has been used to treat urinary tract infections, diarrhea, and cough. 9 A previous chemical investigation of the root bark of M. paniculata var. omphalocarpa.…”

Section: Introductionmentioning

confidence: 99%

Demethoxymurrapanine, an indole‐naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells

Chuang,

Yen,

Shiau

et al. 2023

Environmental Toxicology

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Antioral cancer drugs need a greater antiproliferative impact on cancer than on normal cells. Demethoxymurrapanine (DEMU) inhibits proliferation in several cancer cells, but an in‐depth investigation was necessary. This study evaluated the proliferation‐modulating effects of DEMU, focusing on oral cancer and normal cells. DEMU (0, 2, 3, and 4 μg/mL) at 48 h treatments inhibited the proliferation of oral cancer cells (the cell viability (%) for Ca9‐22 cells was 100.0 ± 2.2, 75.4 ± 5.6, 26.0 ± 3.8, and 15.4 ± 1.4, and for CAL 27 cells was 100.0 ± 9.4, 77.2 ± 5.9, 57.4 ± 10.7, and 27.1 ± 1.1) more strongly than that of normal cells (the cell viability (%) for S‐G cells was 100.0 ± 6.6, 91.0 ± 4.6, 95.0 ± 2.6, and 95.8 ± 5.5), although this was blocked by the antioxidant N‐acetylcysteine. The presence of oxidative stress was evidenced by the increase of reactive oxygen species and mitochondrial superoxide and the downregulation of the cellular antioxidant glutathione in oral cancer cells, but these changes were minor in normal cells. DEMU also caused greater induction of the subG1 phase, extrinsic and intrinsic apoptosis (annexin V and caspases 3, 8, and 9), and DNA damage (γH2AX and 8‐hydroxy‐2‐deoxyguanosine) in oral cancer than in normal cells. N‐acetylcysteine attenuated all these DEMU‐induced changes. Together, these data demonstrate the preferential antiproliferative function of DEMU in oral cancer cells, with the preferential induction of oxidative stress, apoptosis, and DNA damage in these cancer cells, and low cytotoxicity toward normal cells.

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Diversity in Phytochemical Composition and Medicinal Value of Murraya paniculata

Cited by 4 publications

References 39 publications

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

Anticholinesterases activity of Murraya koenigii (L.) Spreng. and Murraya paniculata (L.) Jacq. essential oils with GC/MS analysis and molecular docking

Demethoxymurrapanine, an indole‐naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells

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