Diversity in receptor signalling: cellular individuality and the search for selective drugs

Fredholm, Bertil B.

doi:10.1111/j.1365-2796.1991.tb00366.x

Cited by 4 publications

(1 citation statement)

References 94 publications

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“…However, the involvement of different Gproteins should not be taken as an argument for the presence of more than one receptor, since some receptors may interact with several Gproteins (Fredholm 1991).…”

Section: -_mentioning

confidence: 99%

Fluoride interactions with stimulus‐secretion coupling of normal and pathological parathyroid cells

Ridefelt

Hellman

Rastad

et al. 1992

Acta Physiologica Scandinavica

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Effects of the GTP binding protein (G-protein) activator NaF on parathyroid hormone (PTH) release, cytoplasmic Ca2+ concentration ([Ca2+]i) and cAMP content of bovine as well as normal and pathological human parathyroid cells were studied using precautions to avoid CaF2 precipitation. In 0.5 mM external Ca2+, NaF inhibited PTH release and lowered the cAMP content by 50-70% of the effects attained with 3.0 mM Ca2+. The NaF-induced increase of [Ca2+]i was considerably smaller than that obtained with rise of external Ca2+. It seems likely that NaF activates the inhibitory G1-protein involved in the regulation of cAMP generation. However, it is unclear whether the sluggish rise of [Ca2+]i induced by NaF is due to a direct effect of a G-protein on Ca2+ entry, or somehow related to the G-protein mediated formation of inositol 1,4,5-trisphosphate, which is part of the signal transduction pathway normally initiated by Ca2+ binding to its receptor on the parathyroid cell surface. Inhibition of PTH release by NaF probably results from the combined effects on [Ca2+]i and cAMP content. In hyperparathyroidism (HPT) the actions of NaF were not markedly affected despite severe impairments of Ca(2+)-inhibited PTH release and Ca2+ triggered increase of [Ca2+]i. Consistent with observations of down regulation of the parathyroid Ca2+ receptor in HPT, the present results indicate that the disease perturbs signal transduction at a level proximal to the site of action for NaF.

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Section: -_mentioning

confidence: 99%

Fluoride interactions with stimulus‐secretion coupling of normal and pathological parathyroid cells

Ridefelt

Hellman

Rastad

et al. 1992

Acta Physiologica Scandinavica

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Interleukin (IL)‐4 production by human T cells: differential regulation of IL‐4 vs. IL‐2 production

Pouw-Kraan

Kooten²,

Rensink³

et al. 1992

Eur J Immunol

120

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We have examined the regulation of interleukin (IL)-4 production by human peripheral blood T cells. Production of IL-4 was shown to be regulated differently from IL-2 and interferon(IFN)-gamma production. Stimulation of peripheral blood lymphocytes with anti-CD3, anti-CD2, anti-CD28, Phorbol 12-myristate 13-acetate (PMA) or IL-2 as a single stimulant did not induce IL-4 production. However, combinations of anti-CD2 with either anti-CD28 or IL-2 resulted in IL-4 production, peaking at days 3-4. Stimulation with anti-CD3 instead of anti-CD2 gave similar results, but was less potent. After days 3-4, IL-4 levels decreased, most likely due to consumption of IL-4. PMA profoundly affected cytokine production, it enhanced IL-2 production by at least tenfold, whereas, in the same cell population, IL-4 production was almost completely inhibited. This was observed at the protein as well as at the mRNA level. In contrast, agents that increase intracellular cAMP levels inhibited IL-2 production but left IL-4 production unaffected. IFN-gamma production behaved similar to IL-2 production but the effects were less outspoken.

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Receptor-receptor interactions as an integrative mechanism in nerve cells

et al. 1993

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Several lines of evidence indicate that interactions among transmission lines can take place at the level of the cell membrane via interactions among macromolecules, integral or associated to the cell membrane, involved in signal recognition and transduction. The present view will focus on this last subject, i.e., on the interactions between receptors for chemical signals at the level of the neuronal membrane (receptor-receptor interaction). By receptor-receptor interaction we mean that a neurotransmitter or modulator, by binding to its receptor, modifies the characteristics of the receptor for another transmitter or modulator. Four types of interactions among transmission lines may be considered, but mainly intramembrane receptor-receptor interactions have been dealt with in this article, exemplified by the heteroregulation of D2 receptors via neuropeptide receptors and A2 receptors. The role of receptor-receptor interactions in the integration of signals is discussed, especially in terms of filtration of incoming signals, of integration of coincident signals, and of neuronal plasticity.

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Diversity in receptor signalling: cellular individuality and the search for selective drugs

Cited by 4 publications

References 94 publications

Fluoride interactions with stimulus‐secretion coupling of normal and pathological parathyroid cells

Fluoride interactions with stimulus‐secretion coupling of normal and pathological parathyroid cells

Interleukin (IL)‐4 production by human T cells: differential regulation of IL‐4 vs. IL‐2 production

Receptor-receptor interactions as an integrative mechanism in nerve cells

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